Frazier Life Sciences Management, L.P.

Q4 2025 13F-HR Holdings

Location
Palo Alto, CA
Holdings as of
12/31/2025
Date filed
2/13/2026
Form type
13F-HR
Num holdings
40
Total value ($000)
$3,723,154
Net value change ($000)
+385,756 (11.6%)
New positions
5
Sold out positions
12
Turnover %
16.1%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
NAMS 119,384 25.1%
ARQT 100,621 54.1%
MBX 93,394 80.2%
BBIO 71,467 35.8%
MAZE 70,793 59.8%
PHAT 60,088 41.0%
RNAM 43,682 160.4%
MIRM 38,597 7.7%
ERAS 35,004 70.6%
TRVI 34,574 36.8%
Top Reduces (Value $000, Stocks/ETFs)
VRNA -361,101 -100.0%
RARE -29,590 -100.0%
ZLAB -21,593 -39.2%
MREO -19,447 -100.0%
AKRO -17,415 -100.0%
PCVX -17,088 -100.0%
AGIO -16,534 -32.2%
JBIO -12,197 -100.0%
ASMB -11,680 -100.0%
DSGN -9,823 -66.8%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type