Frazier Life Sciences Management, L.P.

Q1 2026 13F-HR Holdings

Location
Palo Alto, CA
Holdings as of
3/31/2026
Date filed
5/15/2026
Form type
13F-HR
Num holdings
38
Total value ($000)
$3,886,527
Net value change ($000)
+163,373 (4.4%)
New positions
4
Sold out positions
6
Turnover %
6.4%
Sector allocation + QoQ delta (equities-only)
Prev filing: 2/13/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q4 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
ERAS 314,691 372.2%
MIRM 172,702 32.2%
BCRX 38,168 NEW
PVLA 34,377 45.5%
KALV 18,473 22.7%
ACRS 18,470 NEW
CYTK 17,061 28.7%
GLUE 16,450 NEW
VOR 12,109 36.4%
AGIO 7,658 22.0%
Top Reduces (Value $000, Stocks/ETFs)
RNAM -70,913 -100.0%
PHAT -68,316 -33.0%
ARQT -54,113 -18.9%
MAZE -52,889 -28.0%
NAMS -52,018 -8.8%
ABVX -51,016 -100.0%
RAPT -33,305 -100.0%
LXEO -18,540 -42.2%
BBIO -15,141 -5.6%
IRON -13,428 -13.4%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type