Siren, L.L.C.

Q4 2024 13F-HR Holdings

Location
New York, NY
Holdings as of
12/31/2024
Date filed
2/14/2025
Form type
13F-HR
Num holdings
118
Total value ($000)
$2,263,488
Net value change ($000)
+263,165 (13.2%)
New positions
22
Sold out positions
14
Turnover %
15.0%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Snapshot: Change Analysis

Compared to Q3 2024
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
SRRK 309,597 343.3%
SEPN 50,438 NEW
MDGL 38,862 NEW
NAMS 38,577 252.5%
APGE 33,854 NEW
APLS 27,364 43.8%
BCYC 25,752 NEW
STOK 22,060 NEW
SLNO 15,814 NEW
CRNX 15,379 23.0%
Top Reduces (Value $000, Stocks/ETFs)
IGM Biosciences, Inc. -34,736 -63.1%
RNAM -33,391 -50.5%
LXRX -32,303 -52.9%
SLN -31,999 -62.2%
Longboard Pharmaceuticals, Inc. -30,105 -100.0%
BCAX -21,252 -27.2%
KYMR -21,085 -15.0%
KURA -14,511 -55.4%
BHVN -14,168 -100.0%
APLT -12,488 -89.9%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 187 (0.0% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type