Siren, L.L.C.

Q3 2026 13F-HR Holdings

Location
New York, NY
Holdings as of
9/30/2026
Date filed
11/12/2026
Form type
13F-HR
Num holdings
111
Total value ($000)
$4,231,656
Net value change ($000)
-709,748 (-14.4%)
New positions
18
Sold out positions
23
Turnover %
10.8%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Prev filing: 8/13/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q2 2026
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
TYRA 51,111 220.7%
AMLX 45,594 171.5%
ADARx Pharmaceuticals, Inc. 38,400 NEW
ONC 37,651 28.4%
Ascendis Pharma AS 29,618 NEW
AGEN 20,766 637.6%
Damora Therapeutics Inc 19,152 NEW
ENTXW 16,156 1239.0%
Yarrow Bioscience, Inc. 15,201 NEW
SK hynix Inc. 14,732 NEW
Top Reduces (Value $000, Stocks/ETFs)
SRRK -73,625 -14.0%
DFTX -66,773 -100.0%
BCAX -63,942 -38.4%
ABVX -58,142 -75.7%
CRNX -53,166 -100.0%
XENE -52,875 -66.4%
MANE -42,967 -21.1%
COF -34,429 -100.0%
TBLA -27,804 -66.0%
SION -26,857 -100.0%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 12,310 (0.3% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type