Siren, L.L.C.

Q2 2026 13F-HR Holdings

Location
New York, NY
Holdings as of
6/30/2026
Date filed
8/13/2026
Form type
13F-HR
Num holdings
117
Total value ($000)
$4,941,404
Net value change ($000)
+1,334,025 (37.0%)
New positions
25
Sold out positions
10
Turnover %
13.6%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Prev filing: 5/14/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q1 2026
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
MANE 108,448 114.1%
Parabilis Medicines Inc 81,898 NEW
ABVX 76,758 NEW
Hemab Therapeutics Holdings Inc 76,649 NEW
TNGX 74,820 63.2%
KYMR 71,221 26.8%
RLAY 68,292 NEW
RYTM 63,063 99.9%
ELVN 60,799 207.8%
RVMD 60,509 56.0%
Top Reduces (Value $000, Stocks/ETFs)
CNTA -41,844 -100.0%
ENGN -35,774 -100.0%
FULC -18,025 -100.0%
WAVE LIFE SCIENCES LTD -17,763 -100.0%
GPCR -17,191 -26.8%
QURE -16,350 -100.0%
CRNX -15,974 -23.1%
OLMA -10,166 -14.3%
EWTX -10,162 -7.3%
DBVT -8,339 -21.5%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 15,607 (0.3% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type