Palo Alto Investors LP

Q2 2026 13F-HR Holdings

Location
Palo Alto, CA
Holdings as of
6/30/2026
Date filed
8/14/2026
Form type
13F-HR
Num holdings
52
Total value ($000)
$723,718
Net value change ($000)
+69,855 (10.7%)
New positions
4
Sold out positions
4
Turnover %
29.7%
Sector allocation + QoQ delta (equities-only)
Prev filing: 5/15/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q1 2026
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
ACHC 72,462 NEW
PTCT 12,161 19.4%
FIRST TRACKS BIOTHERAPEUTICS 12,142 NEW
RARE 7,420 59.4%
DYN 6,623 22.1%
CDNA 5,925 64.2%
CLDX 5,477 58.3%
NVCR 5,442 39.0%
BCAX 5,394 49.3%
ANAB 5,344 15.1%
Top Reduces (Value $000, Stocks/ETFs)
ACAD -63,946 -100.0%
MIRM -30,040 -100.0%
INSM -23,766 -35.0%
FOLD -16,095 -100.0%
DNLI -4,504 -100.0%
UTHR -3,332 -8.9%
ALGN -1,824 -25.6%
CAPR -1,452 -20.8%
SNDX -1,297 -6.4%
PRTA -556 -4.7%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type