Septerna, Inc. - SEPN

Sector: Healthcare · Industry: Pharmaceutical Preparations

Website: No information yet · Social: No information yet

Company profile

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Q1 2026 · Q4 2025

Value (USD)

Total reported value ($000)

$1.143B

QoQ value delta ($000)

-$135M (-10.57%)

Implied price effect (QoQ)

-13.36%

Total shares

47,329,819

QoQ shares delta

+1,477,919 (+3.22%)

Total shares held by funds (by quarter)

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Top 25 only Full list

Partial Q1 2026 data: 125 holders have filed so far. Prior holders are carried forward until their next 13F confirms a change.

Manager	Value ($000)	Shares	% of 13F
RA CAPITAL MANAGEMENT, L.P.	168,110	6,995,858	1.78%
TRV GP V, LLC	149,360	6,215,591	37.25%
DRIEHAUS CAPITAL MANAGEMENT LLC	105,625	4,395,572	0.78%
TRV GP VI, LLC	101,206	4,211,659	74.64%
Samsara BioCapital, LLC	75,673	3,149,128	7.35%
GOLDMAN SACHS GROUP INC	69,841	2,906,427	0.01%
Siren, L.L.C.	48,060	2,000,000	1.33%
BlackRock, Inc.	43,786	1,822,174	0.0%
VANGUARD GROUP INC	42,048	1,508,195	0.0%
BVF INC/IL	32,518	1,353,249	1.04%
Avoro Capital Advisors LLC	32,140	1,337,500	0.32%
VANGUARD CAPITAL MANAGEMENT LLC	28,762	1,196,962	0.0%
ADAR1 Capital Management, LLC	26,188	1,089,818	1.54%
PRIMECAP MANAGEMENT CO/CA/	25,203	1,048,834	0.02%
JANUS HENDERSON GROUP PLC	21,333	890,754	0.01%
First Light Asset Management, LLC	17,610	732,860	1.58%
GEODE CAPITAL MANAGEMENT, LLC	15,506	645,146	0.0%
STATE STREET CORP	15,173	631,447	0.0%
Casdin Capital, LLC	13,295	553,268	1.01%
Venrock Adviser, LLC	12,160	506,056	0.45%
Catalio Capital Management, LP	7,073	294,360	1.48%
Soleus Capital Management, L.P.	6,608	275,000	0.27%
BALYASNY ASSET MANAGEMENT L.P.	5,687	236,679	0.01%
Universal- Beteiligungs- und Servicegesellschaft mbH	5,382	223,995	0.01%
VANGUARD PORTFOLIO MANAGEMENT LLC	4,686	195,043	0.0%