Septerna, Inc. - SEPN

Detailed investor-level table based on 13F positions.

Shareholders (13F)

Quarter: Q1 2026 · Compare: Q4 2025
13D/13G major owners: Ownership tab.
Methodology: Market value and % of portfolio use SEC reported VALUE ($000). For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received. Details.
Rows: 0
Investor History Status Shares held Market value ($000) % of portfolio Previous % Rank Change in shares % change in shares Source Date reported
RA CAPITAL MANAGEMENT, L.P. History No change 6,995,858 168,110 1.78% 2.0% 1 0 0.0% Q1 2026 May 15, 2026
TRV GP V, LLC History No change 6,215,591 149,360 37.25% 40.38% 2 0 0.0% Q1 2026 May 07, 2026
DRIEHAUS CAPITAL MANAGEMENT LLC History Reduced 4,395,572 105,625 0.78% 0.91% 3 -413,898 -8.61% Q1 2026 May 15, 2026
TRV GP VI, LLC History No change 4,211,659 101,206 74.64% 79.05% 4 0 0.0% Q1 2026 May 07, 2026
Samsara BioCapital, LLC History No change 3,149,128 75,673 7.35% 9.06% 5 0 0.0% Q1 2026 May 15, 2026
GOLDMAN SACHS GROUP INC History Added to 2,906,427 69,841 0.01% 0.01% 6 +191,298 7.05% Q1 2026 May 15, 2026
Siren, L.L.C. History No change 2,000,000 48,060 1.33% 1.66% 7 0 0.0% Q1 2026 May 14, 2026
BlackRock, Inc. History Added to 1,822,174 43,786 0.0% 0.0% 8 +20,846 1.16% Q1 2026 May 13, 2026
VANGUARD GROUP INC History No change 1,508,195 42,048 0.0% 0.0% 9 0 0.0% Q4 2025 Jan 29, 2026
BVF INC/IL History Reduced 1,353,249 32,518 1.04% 1.61% 10 -367,533 -21.36% Q1 2026 May 15, 2026
Avoro Capital Advisors LLC History No change 1,337,500 32,140 0.32% 0.37% 11 0 0.0% Q1 2026 May 15, 2026
VANGUARD CAPITAL MANAGEMENT LLC History New 1,196,962 28,762 0.0% 12 +1,196,962 New Q1 2026 May 15, 2026
ADAR1 Capital Management, LLC History Reduced 1,089,818 26,188 1.54% 2.37% 13 -67,793 -5.86% Q1 2026 May 15, 2026
PRIMECAP MANAGEMENT CO/CA/ History Added to 1,048,834 25,203 0.02% 0.01% 14 +502,734 92.06% Q1 2026 May 11, 2026
JANUS HENDERSON GROUP PLC History New 890,754 21,333 0.01% 15 +890,754 New Q1 2026 May 18, 2026
First Light Asset Management, LLC History Added to 732,860 17,610 1.58% 1.32% 16 +112,049 18.05% Q1 2026 May 15, 2026
GEODE CAPITAL MANAGEMENT, LLC History Added to 645,146 15,506 0.0% 0.0% 17 +72,412 12.64% Q1 2026 May 15, 2026
STATE STREET CORP History Added to 631,447 15,173 0.0% 0.0% 18 +91,419 16.93% Q1 2026 May 15, 2026
Casdin Capital, LLC History No change 553,268 13,295 1.01% 0.96% 19 0 0.0% Q1 2026 May 15, 2026
Venrock Adviser, LLC History Reduced 506,056 12,160 0.45% 0.84% 20 -104,752 -17.15% Q1 2026 May 15, 2026
Catalio Capital Management, LP History No change 294,360 7,073 1.48% 1.45% 21 0 0.0% Q1 2026 May 15, 2026
Soleus Capital Management, L.P. History Reduced 275,000 6,608 0.27% 0.39% 22 -108,368 -28.27% Q1 2026 May 14, 2026
BALYASNY ASSET MANAGEMENT L.P. History Added to 236,679 5,687 0.01% 0.0% 23 +233,108 6527.81% Q1 2026 May 15, 2026
Universal- Beteiligungs- und Servicegesellschaft mbH History Added to 223,995 5,382 0.01% 0.01% 24 +1,293 0.58% Q1 2026 May 11, 2026
VANGUARD PORTFOLIO MANAGEMENT LLC History New 195,043 4,686 0.0% 25 +195,043 New Q1 2026 May 08, 2026
Kalehua Capital Management LLC History No change 194,544 4,674 3.94% 5.36% 26 0 0.0% Q1 2026 May 15, 2026
CHARLES SCHWAB INVESTMENT MANAGEMENT INC History Reduced 181,580 4,363 0.0% 0.0% 27 -5,661 -3.02% Q1 2026 May 15, 2026
NORTHERN TRUST CORP History Added to 164,530 3,953 0.0% 0.0% 28 +10,334 6.7% Q1 2026 May 14, 2026
VANGUARD FIDUCIARY TRUST CO History New 154,484 3,712 0.0% 29 +154,484 New Q1 2026 May 08, 2026
MILLENNIUM MANAGEMENT LLC History Added to 124,101 2,982 0.0% 0.0% 30 +16,638 15.48% Q1 2026 May 15, 2026
UBS Group AG History Added to 116,979 2,811 0.0% 0.0% 31 +48,162 69.99% Q1 2026 May 05, 2026
MORGAN STANLEY History Added to 110,530 2,656 0.0% 0.0% 32 +6,545 6.29% Q1 2026 May 15, 2026
HUSSMAN STRATEGIC ADVISORS, INC. History New 105,000 2,523 0.55% 33 +105,000 New Q1 2026 May 11, 2026
Checkpoint Capital L.P. History New 100,300 2,410 0.86% 34 +100,300 New Q1 2026 May 15, 2026
FEDERATED HERMES, INC. History Added to 89,301 2,145 0.0% 0.0% 35 +10,396 13.18% Q1 2026 May 11, 2026
Invesco Ltd. History Reduced 82,868 1,991 0.0% 0.0% 36 -79,146 -48.85% Q1 2026 May 12, 2026
JPMORGAN CHASE & CO History Added to 84,674 1,972 0.0% 0.0% 37 +16,336 23.9% Q1 2026 May 13, 2026
TWO SIGMA INVESTMENTS, LP History Reduced 75,367 1,811 0.0% 0.0% 38 -17,442 -18.79% Q1 2026 May 15, 2026
Longaeva Partners L.P. History Added to 74,567 1,791 0.07% 0.12% 39 +24,665 49.43% Q1 2026 May 15, 2026
SUSQUEHANNA INTERNATIONAL GROUP, LLP History Reduced 73,000 1,754 0.0% 0.0% 40 -95,600 -56.7% Q1 2026 May 15, 2026
AMERICAN CENTURY COMPANIES INC History Added to 61,290 1,472 0.0% 0.0% 41 +10,601 20.91% Q1 2026 May 15, 2026
Bank of New York Mellon Corp History Added to 58,709 1,410 0.0% 0.0% 42 +3,377 6.1% Q1 2026 May 05, 2026
Jump Financial, LLC History Added to 53,011 1,273 0.02% 0.0% 43 +44,612 531.16% Q1 2026 May 14, 2026
Sofinnova Investments, Inc. History New 47,506 1,141 0.04% 44 +47,506 New Q1 2026 May 15, 2026
MARSHALL WACE, LLP History Reduced 39,840 957 0.0% 0.01% 45 -187,061 -82.44% Q1 2026 May 14, 2026
Rangeley Capital, LLC History Reduced 39,800 956 0.93% 1.52% 46 -26,000 -39.51% Q1 2026 May 15, 2026
RENAISSANCE TECHNOLOGIES LLC History New 37,700 905 0.0% 47 +37,700 New Q1 2026 May 14, 2026
XTX Topco Ltd History Added to 36,723 882 0.02% 0.02% 48 +13,408 57.51% Q1 2026 May 15, 2026
Trexquant Investment LP History Reduced 35,301 848 0.01% 0.01% 49 -8,704 -19.78% Q1 2026 May 15, 2026
Alyeska Investment Group, L.P. History No change 35,000 841 0.0% 0.0% 50 0 0.0% Q1 2026 May 15, 2026
ACADIAN ASSET MANAGEMENT LLC History Added to 30,978 741 0.0% 0.0% 51 +101 0.33% Q1 2026 May 13, 2026
TWO SIGMA ADVISERS, LP History No change 25,700 716 0.0% 0.0% 52 0 0.0% Q4 2025 Feb 17, 2026
Nuveen, LLC History Added to 29,176 701 0.0% 0.0% 53 +3,378 13.09% Q1 2026 Apr 30, 2026
JACOBS LEVY EQUITY MANAGEMENT, INC History Reduced 28,436 683 0.0% 0.01% 54 -32,934 -53.66% Q1 2026 May 15, 2026
PRICE T ROWE ASSOCIATES INC /MD/ History Added to 28,076 675 0.0% 0.0% 55 +2,633 10.35% Q1 2026 May 15, 2026
RHUMBLINE ADVISERS History Added to 26,604 639 0.0% 0.0% 56 +185 0.7% Q1 2026 May 12, 2026
BANK OF AMERICA CORP /DE/ History Reduced 25,973 624 0.0% 0.0% 57 -11,621 -30.91% Q1 2026 May 15, 2026
Y-Intercept (Hong Kong) Ltd History New 25,770 619 0.01% 58 +25,770 New Q1 2026 Apr 27, 2026
ADAGE CAPITAL PARTNERS GP, L.L.C. History New 24,000 576 0.0% 59 +24,000 New Q1 2026 May 15, 2026
Logos Global Management LP History No change 23,548 565 0.03% 0.04% 60 0 0.0% Q1 2026 May 15, 2026
FMR LLC History Added to 23,446 563 0.0% 0.0% 61 +20,139 608.98% Q1 2026 May 15, 2026
ALLIANCEBERNSTEIN L.P. History No change 19,600 546 0.0% 0.0% 62 0 0.0% Q1 2026 May 15, 2026
BARCLAYS PLC History Reduced 22,714 545 0.0% 0.0% 63 -15,433 -40.46% Q1 2026 May 14, 2026
Swiss National Bank History New 22,100 531 0.0% 64 +22,100 New Q1 2026 May 07, 2026
ALGERT GLOBAL LLC History Reduced 21,035 505 0.01% 0.02% 65 -13,909 -39.8% Q1 2026 May 14, 2026
Squarepoint Ops LLC History Added to 18,083 434 0.0% 0.0% 66 +3,236 21.8% Q1 2026 May 15, 2026
STRS OHIO History Added to 17,200 413 0.0% 0.0% 67 +2,600 17.81% Q1 2026 Apr 24, 2026
DEUTSCHE BANK AG\ History Added to 16,843 404 0.0% 0.0% 68 +1,964 13.2% Q1 2026 May 06, 2026
VARCOV Co. History Reduced 16,752 402 0.15% 0.25% 69 -5,882 -25.99% Q1 2026 May 15, 2026
Engineers Gate Manager LP History New 16,528 397 0.0% 70 +16,528 New Q1 2026 May 15, 2026
Vanguard Global Advisers, LLC History New 16,247 390 0.0% 71 +16,247 New Q1 2026 May 08, 2026
AQR CAPITAL MANAGEMENT LLC History Added to 15,375 369 0.0% 0.0% 72 +7,549 96.46% Q1 2026 May 15, 2026
Numerai GP LLC History Reduced 15,082 362 0.04% 0.15% 73 -30,784 -67.12% Q1 2026 May 15, 2026
LOS ANGELES CAPITAL MANAGEMENT LLC History Reduced 14,214 341 0.0% 0.0% 74 -4,336 -23.37% Q1 2026 May 08, 2026
MetLife Investment Management, LLC History No change 13,685 328 0.0% 0.0% 75 0 0.0% Q1 2026 May 14, 2026
EntryPoint Capital, LLC History New 12,776 307 0.09% 76 +12,776 New Q1 2026 May 14, 2026
OSAIC HOLDINGS, INC. History Added to 12,698 305 0.0% 0.0% 77 +5 0.04% Q1 2026 May 15, 2026
Verition Fund Management LLC History New 12,343 296 0.0% 78 +12,343 New Q1 2026 May 15, 2026
China Universal Asset Management Co., Ltd. History Added to 11,946 287 0.02% 0.02% 79 +1,650 16.03% Q1 2026 Apr 27, 2026
Man Group plc History New 11,858 284 0.0% 80 +11,858 New Q1 2026 May 15, 2026
Russell Investments Group, Ltd. History Reduced 11,515 276 0.0% 0.0% 81 -3,795 -24.79% Q1 2026 May 08, 2026
Seven Fleet Capital Management LP History No change 11,445 275 0.09% 0.22% 82 0 0.0% Q1 2026 Jun 04, 2026
Virtus Investment Advisers, LLC History Added to 10,719 257 0.07% 0.08% 83 +262 2.51% Q1 2026 May 14, 2026
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ History New 10,382 249 0.0% 84 +10,382 New Q1 2026 May 14, 2026
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. History Added to 10,021 240 0.0% 0.0% 85 +87 0.88% Q1 2026 May 15, 2026
WELLS FARGO & COMPANY/MN History Reduced 9,869 237 0.0% 0.0% 86 -16,660 -62.8% Q1 2026 May 11, 2026
CITIGROUP INC History Reduced 9,195 220 0.0% 0.0% 87 -366 -3.83% Q1 2026 May 11, 2026
WINTON GROUP Ltd History New 8,842 212 0.01% 88 +8,842 New Q1 2026 May 12, 2026
VANGUARD ASSET MANAGEMENT, Ltd History New 7,420 178 0.0% 89 +7,420 New Q1 2026 May 08, 2026
Legal & General Group Plc History Added to 5,735 137 0.0% 0.0% 90 +3,790 194.86% Q1 2026 May 08, 2026
NEW YORK STATE COMMON RETIREMENT FUND History No change 5,600 134 0.0% 0.0% 91 0 0.0% Q1 2026 May 06, 2026
BNP PARIBAS FINANCIAL MARKETS History Reduced 5,361 128 0.0% 0.0% 92 -88 -1.61% Q1 2026 May 12, 2026
Police & Firemen's Retirement System of New Jersey History No change 5,175 124 0.0% 0.0% 93 0 0.0% Q1 2026 Apr 29, 2026
Vanguard Investments Australia, Ltd. History New 3,895 93 0.0% 94 +3,895 New Q1 2026 May 08, 2026
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO History Reduced 3,374 81 0.0% 0.0% 95 -7,220 -68.15% Q1 2026 May 14, 2026
KLP KAPITALFORVALTNING AS History New 2,500 60 0.0% 96 +2,500 New Q1 2026 Apr 29, 2026
Mirae Asset Global Investments Co., Ltd. History Added to 2,335 56 0.0% 0.0% 97 +159 7.31% Q1 2026 May 04, 2026
Covestor Ltd History Added to 2,260 54 0.04% 0.03% 98 +319 16.43% Q1 2026 May 05, 2026
Ameritas Investment Partners, Inc. History No change 1,944 46 0.0% 0.0% 99 0 0.0% Q1 2026 May 13, 2026
Global Retirement Partners, LLC History No change 1,256 35 0.0% 0.0% 100 0 0.0% Q4 2025 Feb 06, 2026
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM History Reduced 1,157 27 0.0% 0.0% 101 -159 -12.08% Q1 2026 May 15, 2026
GAMMA Investing LLC History Added to 1,110 26 0.0% 0.0% 102 +194 21.18% Q1 2026 Apr 06, 2026
GF FUND MANAGEMENT CO. LTD. History Added to 1,006 24 0.0% 0.0% 103 +128 14.58% Q1 2026 Apr 15, 2026
SIGNATUREFD, LLC History Reduced 966 23 0.0% 0.0% 104 -23 -2.33% Q1 2026 Apr 07, 2026
CWM, LLC History Added to 894 21 0.0% 0.0% 105 +6 0.68% Q1 2026 May 14, 2026
NISA INVESTMENT ADVISORS, LLC History Added to 841 20 0.0% 0.0% 106 +500 146.63% Q1 2026 Apr 30, 2026
Tower Research Capital LLC (TRC) History Reduced 717 17 0.0% 0.0% 108 -1,439 -66.74% Q1 2026 May 15, 2026
Sterling Capital Management LLC History Reduced 712 17 0.0% 0.0% 107 -520 -42.21% Q1 2026 Apr 22, 2026
Zurcher Kantonalbank (Zurich Cantonalbank) History New 508 12 0.0% 109 +508 New Q1 2026 May 15, 2026
Pinnacle Wealth Planning Services, Inc. History No change 322 7 0.0% 0.0% 110 0 0.0% Q1 2026 May 11, 2026
Versant Capital Management, Inc History No change 261 6 0.0% 0.0% 111 0 0.0% Q1 2026 Apr 06, 2026
Larson Financial Group LLC History New 204 4 0.0% 114 +204 New Q1 2026 May 15, 2026
DIADEMA PARTNERS LP History New 202 4 0.0% 115 +202 New Q1 2026 May 15, 2026
US BANCORP \DE\ History Added to 197 4 0.0% 0.0% 112 +7 3.68% Q1 2026 May 14, 2026
N.E.W. Advisory Services LLC History No change 180 4 0.0% 0.0% 113 0 0.0% Q1 2026 May 04, 2026
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC History New 155 3 0.0% 117 +155 New Q1 2026 May 13, 2026
MassMutual Private Wealth & Trust, FSB History Added to 135 3 0.0% 0.0% 116 +72 114.29% Q1 2026 Apr 13, 2026
PNC FINANCIAL SERVICES GROUP, INC. History Reduced 43 1 0.0% 0.0% 118 -155 -78.28% Q1 2026 May 08, 2026
EverSource Wealth Advisors, LLC History Added to 68 1 0.0% 0.0% 119 +5 7.94% Q1 2026 May 15, 2026
SBI Securities Co., Ltd. History No change 55 1 0.0% 0.0% 120 0 0.0% Q1 2026 Apr 27, 2026
Cornerstone Financial Management LLC History No change 52 1 0.0% 0.0% 121 0 0.0% Q1 2026 May 08, 2026
PERCEPTIVE ADVISORS LLC History Closed out 0 0 0.22% -433,160 -100.0% Q1 2026 May 29, 2026
Woodline Partners LP History Closed out 0 0 0.04% -385,310 -100.0% Q1 2026 May 15, 2026
JANE STREET GROUP, LLC History Closed out 0 0 0.0% -124,270 -100.0% Q1 2026 May 12, 2026
CITADEL ADVISORS LLC History Closed out 0 0 0.0% -87,845 -100.0% Q1 2026 May 15, 2026
HighVista Strategies LLC History Closed out 0 0 0.56% -78,682 -100.0% Q1 2026 May 15, 2026
ExodusPoint Capital Management, LP History Closed out 0 0 0.01% -37,867 -100.0% Q1 2026 May 14, 2026
TUDOR INVESTMENT CORP ET AL History Closed out 0 0 0.0% -18,053 -100.0% Q1 2026 May 15, 2026
FRANKLIN RESOURCES INC History Closed out 0 0 0.0% -16,852 -100.0% Q1 2026 May 13, 2026
AMERIPRISE FINANCIAL INC History Closed out 0 0 0.0% -14,090 -100.0% Q1 2026 May 15, 2026
INTECH INVESTMENT MANAGEMENT LLC History Closed out 0 0 0.0% -13,283 -100.0% Q1 2026 May 08, 2026
Dynamic Technology Lab Private Ltd History Closed out 0 0 0.07% -10,810 -100.0% Q1 2026 May 15, 2026
PharVision Advisers, LLC History Closed out 0 0 0.15% -10,739 -100.0% Q1 2026 May 11, 2026
Baader Bank Aktiengesellschaft History Closed out 0 0 0.02% -10,000 -100.0% Q1 2026 May 08, 2026
Atom Investors LP History Closed out 0 0 0.02% -9,791 -100.0% Q1 2026 May 15, 2026
Graham Capital Management, L.P. History Closed out 0 0 0.01% -8,971 -100.0% Q1 2026 May 15, 2026
BANK OF NOVA SCOTIA History Closed out 0 0 0.0% -8,300 -100.0% Q1 2026 May 14, 2026
Caitong International Asset Management Co., Ltd History Reduced 38 0 0.04% -6,302 -99.4% Q1 2026 May 11, 2026
GROUP ONE TRADING LLC History Closed out 0 0 0.0% -944 -100.0% Q1 2026 May 13, 2026
Quarry LP History Closed out 0 0 0.0% -724 -100.0% Q1 2026 May 15, 2026
AMALGAMATED BANK History Closed out 0 0 0.0% -672 -100.0% Q1 2026 May 08, 2026
ROYAL BANK OF CANADA History Closed out 0 0 0.0% -628 -100.0% Q1 2026 May 15, 2026
Daiwa Securities Group Inc. History Closed out 0 0 0.0% -149 -100.0% Q1 2026 May 13, 2026
Fortitude Family Office, LLC History Reduced 20 0 0.0% -51 -71.83% Q1 2026 Apr 15, 2026
Aster Capital Management (DIFC) Ltd History Closed out 0 0 -20 -100.0% Q1 2026 May 13, 2026
Allworth Financial LP History New 17 0 +17 New Q1 2026 May 14, 2026
QUADRANT CAPITAL GROUP LLC History New 7 0 +7 New Q1 2026 May 13, 2026
Farther Finance Advisors, LLC History Added to 7 0 +6 600.0% Q1 2026 Apr 07, 2026
MAI Capital Management History New 6 0 +6 New Q1 2026 May 15, 2026
Arax Advisory Partners History Closed out 0 0 -3 -100.0% Q1 2026 May 13, 2026
ROTHSCHILD INVESTMENT LLC History No change 30 0 0 0.0% Q1 2026 May 07, 2026