4525EP200
Detailed investor-level table based on 13F positions.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BVF INC/IL | History | No change | 765,295 | 11,762 | 0.3% | 0.3% | 1 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| MILLENNIUM MANAGEMENT LLC | History | No change | 740,347 | 11,379 | 0.0% | 0.0% | 2 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Avidity Partners Management LP | History | No change | 669,941 | 10,296 | 1.65% | 1.65% | 3 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Aberdeen Group plc | History | Added to | 1,090,427 | 10,140 | 0.01% | 0.02% | 4 | +266,034 | 32.27% | Q3 2026 | Nov 10, 2026 |
| BRAIDWELL LP | History | No change | 645,010 | 9,913 | 0.37% | 0.37% | 5 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | History | No change | 571,561 | 8,784 | 0.0% | 0.0% | 6 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Jones Hill Capital LP | History | No change | 539,814 | 8,296 | 1.76% | 1.76% | 7 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Woodline Partners LP | History | No change | 471,528 | 7,247 | 0.02% | 0.02% | 8 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Soleus Capital Management, L.P. | History | No change | 450,000 | 6,916 | 0.24% | 0.24% | 9 | 0 | 0.0% | Q2 2026 | Aug 11, 2026 |
| Laurion Capital Management LP | History | No change | 610,326 | 5,676 | 0.09% | 0.24% | 10 | 0 | 0.0% | Q3 2026 | Oct 30, 2026 |
| Propel Bio Management, LLC | History | No change | 325,022 | 4,995 | 2.61% | 2.61% | 11 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | History | No change | 259,690 | 3,991 | 0.0% | 0.0% | 12 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Nantahala Capital Management, LLC | History | No change | 250,646 | 3,852 | 0.13% | 0.13% | 13 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| 683 Capital Management, LLC | History | No change | 147,245 | 2,263 | 0.11% | 0.11% | 14 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | History | No change | 139,860 | 2,149 | 0.0% | 0.0% | 15 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| BlackRock, Inc. | History | No change | 132,791 | 2,040 | 0.0% | 0.0% | 16 | 0 | 0.0% | Q2 2026 | Aug 07, 2026 |
| UBS Group AG | History | Added to | 183,629 | 1,707 | 0.0% | 0.0% | 17 | +7,873 | 4.48% | Q3 2026 | Nov 10, 2026 |
| JANE STREET GROUP, LLC | History | No change | 104,987 | 1,613 | 0.0% | 0.0% | 18 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| MARSHALL WACE, LLP | History | No change | 104,816 | 1,611 | 0.0% | 0.0% | 19 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | History | Added to | 172,142 | 1,601 | 0.0% | 0.0% | 20 | +1,467 | 0.86% | Q3 2026 | Nov 06, 2026 |
| VANGUARD FIDUCIARY TRUST CO | History | No change | 82,029 | 1,260 | 0.0% | 0.0% | 21 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Ikarian Capital, LLC | History | No change | 67,464 | 1,036 | 0.11% | 0.11% | 22 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| STATE STREET CORP | History | Added to | 83,859 | 779 | 0.0% | 0.0% | 23 | +22,600 | 36.89% | Q3 2026 | Nov 12, 2026 |
| Quadrature Capital Ltd | History | No change | 37,786 | 580 | 0.0% | 0.0% | 24 | 0 | 0.0% | Q2 2026 | Aug 06, 2026 |
| CITADEL ADVISORS LLC | History | No change | 35,380 | 543 | 0.0% | 0.0% | 25 | 0 | 0.0% | Q2 2026 | Sep 02, 2026 |
| NORTHERN TRUST CORP | History | No change | 30,720 | 472 | 0.0% | 0.0% | 26 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Squarepoint Ops LLC | History | New | 42,283 | 393 | 0.0% | — | 27 | +42,283 | New | Q3 2026 | Nov 09, 2026 |
| MORGAN STANLEY | History | No change | 23,748 | 365 | 0.0% | 0.0% | 28 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Brevan Howard Capital Management LP | History | No change | 23,181 | 356 | 0.0% | 0.0% | 29 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| BNP PARIBAS FINANCIAL MARKETS | History | No change | 22,909 | 352 | 0.0% | 0.0% | 30 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Simplify Asset Management Inc. | History | No change | 30,725 | 285 | 0.0% | 0.01% | 31 | 0 | 0.0% | Q3 2026 | Oct 27, 2026 |
| MML INVESTORS SERVICES, LLC | History | No change | 14,662 | 225 | 0.0% | 0.0% | 32 | 0 | 0.0% | Q2 2026 | Aug 07, 2026 |
| BOOTHBAY FUND MANAGEMENT, LLC | History | No change | 13,057 | 200 | 0.0% | 0.0% | 33 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Point72 Asset Management, L.P. | History | No change | 10,806 | 166 | 0.0% | 0.0% | 34 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| ALPS ADVISORS INC | History | Added to | 17,694 | 164 | 0.0% | 0.0% | 35 | +3,870 | 27.99% | Q3 2026 | Nov 02, 2026 |
| LPL Financial LLC | History | Reduced | 17,012 | 158 | 0.0% | 0.0% | 36 | -429 | -2.46% | Q3 2026 | Nov 06, 2026 |
| Strategies Wealth Advisors, LLC | History | No change | 10,000 | 153 | 0.01% | 0.01% | 37 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| China Universal Asset Management Co., Ltd. | History | Added to | 7,800 | 69 | 0.0% | 0.01% | 38 | +1,400 | 21.88% | Q3 2026 | Oct 27, 2026 |
| SIMPLEX TRADING, LLC | History | New | 6,667 | 62 | 0.0% | — | 39 | +6,667 | New | Q3 2026 | Nov 04, 2026 |
| Vanguard Global Advisers, LLC | History | No change | 3,186 | 48 | 0.0% | 0.0% | 40 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| BARCLAYS PLC | History | Added to | 4,025 | 37 | 0.0% | 0.0% | 41 | +3,531 | 714.78% | Q3 2026 | Nov 06, 2026 |
| ACADIAN ASSET MANAGEMENT LLC | History | New | 3,549 | 32 | 0.0% | — | 42 | +3,549 | New | Q3 2026 | Nov 09, 2026 |
| ROYAL BANK OF CANADA | History | No change | 1,000 | 15 | 0.0% | 0.0% | 43 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| OSAIC HOLDINGS, INC. | History | No change | 1,000 | 15 | 0.0% | 0.0% | 44 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| CITIGROUP INC | History | Reduced | 1,517 | 14 | 0.0% | 0.0% | 45 | -3,052 | -66.8% | Q3 2026 | Nov 04, 2026 |
| Providence Capital Advisors, LLC | History | No change | 682 | 10 | 0.0% | 0.0% | 46 | 0 | 0.0% | Q2 2026 | Aug 11, 2026 |
| SBI Securities Co., Ltd. | History | Added to | 515 | 4 | 0.0% | 0.0% | 47 | +142 | 38.07% | Q3 2026 | Oct 21, 2026 |
| FMR LLC | History | Added to | 337 | 3 | 0.0% | 0.0% | 48 | +209 | 163.28% | Q3 2026 | Nov 10, 2026 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | History | No change | 150 | 2 | 0.0% | 0.0% | 49 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| WELLS FARGO & COMPANY/MN | History | No change | 87 | 1 | 0.0% | 0.0% | 50 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Allworth Financial LP | History | No change | 84 | 1 | 0.0% | 0.0% | 51 | 0 | 0.0% | Q3 2026 | Nov 06, 2026 |
| Rockefeller Capital Management L.P. | History | No change | 100 | 1 | 0.0% | 0.0% | 52 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Jefferies Financial Group Inc. | History | Closed out | 0 | 0 | — | 0.01% | — | -84,900 | -100.0% | Q3 2026 | Nov 05, 2026 |
| Belvedere Trading LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -20,900 | -100.0% | Q3 2026 | Nov 05, 2026 |
| GROUP ONE TRADING LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -145 | -100.0% | Q3 2026 | Nov 10, 2026 |
| Nova Financial LLC | History | New | 80 | 0 | — | — | — | +80 | New | Q3 2026 | Nov 04, 2026 |
| Cassaday & Co Wealth Management LLC | History | New | 40 | 0 | — | — | — | +40 | New | Q3 2026 | Oct 27, 2026 |
| Caitong International Asset Management Co., Ltd | History | Added to | 18 | 0 | — | — | — | +16 | 800.0% | Q3 2026 | Oct 29, 2026 |
| Smartleaf Asset Management LLC | History | New | 2 | 0 | — | — | — | +2 | New | Q3 2026 | Nov 10, 2026 |
| JPMORGAN CHASE & CO | History | No change | 38 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| CALDWELL SUTTER CAPITAL, INC. | History | No change | 10 | 0 | — | — | — | 0 | 0.0% | Q3 2026 | Nov 09, 2026 |
| DANSKE BANK A/S | History | No change | 2 | 0 | — | — | — | 0 | 0.0% | Q3 2026 | Nov 09, 2026 |
| SHP Wealth Management | History | No change | 14 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 11, 2026 |