Applied Therapeutics, Inc. - APLT
Detailed investor-level table based on 13F positions.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | History | Reduced | 8,344,483 | 835 | 0.0% | 0.01% | 1 | -13,058,817 | -61.01% | Q4 2025 | Feb 19, 2026 |
| VANGUARD GROUP INC | History | Added to | 6,353,018 | 635 | 0.0% | 0.0% | 2 | +1,250,329 | 24.5% | Q4 2025 | Jan 29, 2026 |
| Knoll Capital Management, LLC | History | Reduced | 6,050,000 | 605 | 0.28% | 2.52% | 3 | -1,749,687 | -22.43% | Q4 2025 | Feb 17, 2026 |
| DELTEC ASSET MANAGEMENT LLC | History | New | 3,847,449 | 384 | 0.06% | — | 4 | +3,847,449 | New | Q4 2025 | Jan 29, 2026 |
| BlackRock, Inc. | History | Reduced | 3,251,462 | 325 | 0.0% | 0.0% | 5 | -592,271 | -15.41% | Q4 2025 | Feb 12, 2026 |
| Pathstone Holdings, LLC | History | New | 2,643,540 | 305 | 0.0% | — | 6 | +2,643,540 | New | Q4 2025 | Feb 13, 2026 |
| RENAISSANCE TECHNOLOGIES LLC | History | New | 2,706,156 | 270 | 0.0% | — | 7 | +2,706,156 | New | Q4 2025 | Feb 12, 2026 |
| JANE STREET GROUP, LLC | History | Added to | 2,087,404 | 208 | 0.0% | 0.0% | 8 | +2,025,804 | 3288.64% | Q4 2025 | Feb 12, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | History | Added to | 1,492,903 | 149 | 0.0% | 0.0% | 9 | +214,747 | 16.8% | Q4 2025 | Feb 09, 2026 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | History | Reduced | 1,211,629 | 121 | 0.0% | 0.0% | 10 | -1,000,000 | -45.22% | Q4 2025 | Feb 17, 2026 |
| MILLENNIUM MANAGEMENT LLC | History | Reduced | 1,051,846 | 105 | 0.0% | 0.0% | 11 | -855,368 | -44.85% | Q4 2025 | Feb 17, 2026 |
| UBS Group AG | History | Reduced | 718,924 | 71 | 0.0% | 0.0% | 12 | -1,186,701 | -62.27% | Q4 2025 | Jan 29, 2026 |
| DEUTSCHE BANK AG\ | History | No change | 622,226 | 62 | 0.0% | 0.0% | 13 | 0 | 0.0% | Q4 2025 | Feb 11, 2026 |
| Graham Capital Management, L.P. | History | New | 572,759 | 57 | 0.0% | — | 14 | +572,759 | New | Q4 2025 | Feb 17, 2026 |
| EQUITEC PROPRIETARY MARKETS, LLC | History | New | 553,000 | 55 | 0.03% | — | 16 | +553,000 | New | Q4 2025 | Feb 17, 2026 |
| STATE STREET CORP | History | Added to | 558,178 | 55 | 0.0% | 0.0% | 15 | +39,660 | 7.65% | Q4 2025 | Feb 13, 2026 |
| Virtu Financial LLC | History | Added to | 496,288 | 50 | 0.0% | 0.0% | 17 | +445,271 | 872.79% | Q4 2025 | Feb 23, 2026 |
| Lynx1 Capital Management LP | History | New | 410,500 | 41 | 0.01% | — | 18 | +410,500 | New | Q4 2025 | Feb 17, 2026 |
| MARSHALL WACE, LLP | History | Reduced | 337,389 | 33 | 0.0% | 0.0% | 19 | -2,205,299 | -86.73% | Q4 2025 | Feb 13, 2026 |
| Hennion & Walsh Asset Management, Inc. | History | Added to | 327,137 | 32 | 0.0% | 0.01% | 20 | +44,289 | 15.66% | Q4 2025 | Jan 14, 2026 |
| Bank of New York Mellon Corp | History | Added to | 253,575 | 25 | 0.0% | 0.0% | 21 | +174,157 | 219.29% | Q4 2025 | Feb 10, 2026 |
| Rockefeller Capital Management L.P. | History | Reduced | 241,897 | 24 | 0.0% | 0.0% | 23 | -150,000 | -38.28% | Q4 2025 | Mar 16, 2026 |
| NORTHERN TRUST CORP | History | Added to | 245,144 | 24 | 0.0% | 0.0% | 22 | +71,429 | 41.12% | Q4 2025 | Feb 17, 2026 |
| GTS SECURITIES LLC | History | New | 200,009 | 20 | 0.0% | — | 24 | +200,009 | New | Q4 2025 | Feb 13, 2026 |
| CITADEL ADVISORS LLC | History | Reduced | 192,700 | 19 | 0.0% | 0.0% | 25 | -59,400 | -23.56% | Q4 2025 | Feb 17, 2026 |
| MORGAN STANLEY | History | Reduced | 178,474 | 17 | 0.0% | 0.0% | 26 | -534,841 | -74.98% | Q4 2025 | Feb 13, 2026 |
| CITIGROUP INC | History | Added to | 163,449 | 16 | 0.0% | 0.0% | 27 | +156,608 | 2289.26% | Q4 2025 | Feb 13, 2026 |
| CreativeOne Wealth, LLC | History | Added to | 169,974 | 16 | 0.0% | 0.0% | 28 | +69,962 | 69.95% | Q4 2025 | Feb 13, 2026 |
| GOLDMAN SACHS GROUP INC | History | Reduced | 146,219 | 14 | 0.0% | 0.0% | 29 | -8,922 | -5.75% | Q4 2025 | Mar 25, 2026 |
| Roble, Belko & Company, Inc | History | Added to | 65,571 | 7 | 0.0% | 0.0% | 30 | +34,730 | 112.61% | Q4 2025 | Jan 12, 2026 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | History | Reduced | 52,692 | 5 | 0.0% | 0.0% | 32 | -587,265 | -91.77% | Q4 2025 | Feb 17, 2026 |
| TUDOR INVESTMENT CORP ET AL | History | No change | 57,454 | 5 | 0.0% | 0.16% | 31 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| SPHERA FUNDS MANAGEMENT LTD. | History | No change | 50,000 | 5 | 0.0% | 0.01% | 33 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| GROUP ONE TRADING LLC | History | Reduced | 48,675 | 4 | 0.0% | 0.0% | 34 | -26,586 | -35.33% | Q4 2025 | Feb 12, 2026 |
| SG Americas Securities, LLC | History | Added to | 41,748 | 4 | 0.0% | 0.0% | 35 | +25,344 | 154.5% | Q4 2025 | Jan 09, 2026 |
| Adams Wealth Management | History | No change | 38,637 | 3 | 0.0% | 0.0% | 36 | 0 | 0.0% | Q4 2025 | Feb 18, 2026 |
| CacheTech Inc. | History | No change | 38,637 | 3 | 0.0% | 0.0% | 37 | 0 | 0.0% | Q4 2025 | Feb 18, 2026 |
| DIADEMA PARTNERS LP | History | Added to | 20,200 | 2 | 0.0% | 0.0% | 38 | +1,200 | 6.32% | Q4 2025 | Feb 17, 2026 |
| AQR CAPITAL MANAGEMENT LLC | History | Reduced | 13,413 | 1 | 0.0% | 0.0% | 40 | -96,274 | -87.77% | Q4 2025 | Feb 17, 2026 |
| Point72 Asset Management, L.P. | History | New | 17,020 | 1 | 0.0% | — | 42 | +17,020 | New | Q4 2025 | Feb 17, 2026 |
| Tower Research Capital LLC (TRC) | History | Reduced | 19,675 | 1 | 0.0% | 0.0% | 41 | -14,680 | -42.73% | Q4 2025 | Feb 17, 2026 |
| JPMORGAN CHASE & CO | History | Added to | 12,064 | 1 | 0.0% | 0.0% | 39 | +4,433 | 58.09% | Q4 2025 | Feb 11, 2026 |
| Cresset Asset Management, LLC | History | No change | 17,091 | 1 | 0.0% | 0.0% | 43 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| Perennial Investment Advisors, LLC | History | No change | 11,600 | 1 | 0.0% | 0.0% | 44 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| Vestal Point Capital, LP | History | Closed out | 0 | 0 | — | 0.39% | — | -14,250,000 | -100.0% | Q3 2025 | Nov 14, 2025 |
| Propel Bio Management, LLC | History | Closed out | 0 | 0 | — | 6.83% | — | -11,285,420 | -100.0% | Q3 2025 | Nov 12, 2025 |
| Simplify Asset Management Inc. | History | Closed out | 0 | 0 | — | 0.05% | — | -4,487,505 | -100.0% | Q3 2025 | Oct 20, 2025 |
| PNC FINANCIAL SERVICES GROUP, INC. | History | Closed out | 0 | 0 | — | 0.0% | — | -2,901,184 | -100.0% | Q3 2025 | Nov 07, 2025 |
| Rock Springs Capital Management LP | History | Closed out | 0 | 0 | — | 0.07% | — | -2,075,991 | -100.0% | Q3 2025 | Nov 14, 2025 |
| FRANKLIN RESOURCES INC | History | Closed out | 0 | 0 | — | 0.0% | — | -2,003,338 | -100.0% | Q3 2025 | Nov 13, 2025 |
| Qube Research & Technologies Ltd | History | Closed out | 0 | 0 | — | 0.0% | — | -1,167,269 | -100.0% | Q3 2025 | Nov 14, 2025 |
| Hudson Bay Capital Management LP | History | Closed out | 0 | 0 | — | 0.0% | — | -805,464 | -100.0% | Q3 2025 | Dec 15, 2025 |
| Birchview Capital, LP | History | Closed out | 0 | 0 | — | 0.1% | — | -225,000 | -100.0% | Q3 2025 | Nov 13, 2025 |
| TWO SIGMA INVESTMENTS, LP | History | Closed out | 0 | 0 | — | 0.0% | — | -198,933 | -100.0% | Q3 2025 | Nov 14, 2025 |
| Squarepoint Ops LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -158,865 | -100.0% | Q3 2025 | Nov 14, 2025 |
| Scientech Research LLC | History | Closed out | 0 | 0 | — | 0.02% | — | -105,110 | -100.0% | Q3 2025 | Nov 14, 2025 |
| HRT FINANCIAL LP | History | Closed out | 0 | 0 | — | 0.0% | — | -94,870 | -100.0% | Q3 2025 | Nov 14, 2025 |
| Ethic Inc. | History | Closed out | 0 | 0 | — | 0.0% | — | -27,193 | -100.0% | Q3 2025 | Oct 17, 2025 |
| China Universal Asset Management Co., Ltd. | History | Closed out | 0 | 0 | — | 0.0% | — | -25,243 | -100.0% | Q3 2025 | Nov 10, 2025 |
| XTX Topco Ltd | History | Closed out | 0 | 0 | — | 0.0% | — | -23,579 | -100.0% | Q3 2025 | Nov 14, 2025 |
| FMR LLC | History | Reduced | 184 | 0 | — | 0.0% | — | -17,298 | -98.95% | Q4 2025 | Feb 17, 2026 |
| Cerity Partners LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -16,803 | -100.0% | Q3 2025 | Oct 22, 2025 |
| Vanguard Personalized Indexing Management, LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -16,244 | -100.0% | Q3 2025 | Oct 31, 2025 |
| Stratos Wealth Advisors, LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -10,500 | -100.0% | Q3 2025 | Nov 06, 2025 |
| Algorithmic Investment Models, LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -10,403 | -100.0% | Q3 2025 | Nov 10, 2025 |
| BANK OF AMERICA CORP /DE/ | History | Reduced | 3,109 | 0 | — | 0.0% | — | -8,561 | -73.36% | Q4 2025 | Feb 17, 2026 |
| Mirae Asset Global Investments Co., Ltd. | History | Closed out | 0 | 0 | — | 0.0% | — | -5,568 | -100.0% | Q3 2025 | Nov 03, 2025 |
| BARCLAYS PLC | History | Reduced | 1 | 0 | — | 0.0% | — | -5,264 | -99.98% | Q4 2025 | Feb 13, 2026 |
| Capital Advisors, Ltd. LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -2,367 | -100.0% | Q3 2025 | Oct 16, 2025 |
| Sunbelt Securities, Inc. | History | Closed out | 0 | 0 | — | — | — | -1,000 | -100.0% | Q3 2025 | Nov 19, 2025 |
| ROYAL BANK OF CANADA | History | New | 852 | 0 | — | — | — | +852 | New | Q4 2025 | Feb 17, 2026 |
| BNP PARIBAS FINANCIAL MARKETS | History | Reduced | 2,974 | 0 | — | 0.0% | — | -501 | -14.42% | Q4 2025 | Feb 10, 2026 |
| Optiver Holding B.V. | History | New | 427 | 0 | — | — | — | +427 | New | Q4 2025 | Feb 17, 2026 |
| CWM, LLC | History | Closed out | 0 | 0 | — | — | — | -376 | -100.0% | Q3 2025 | Oct 15, 2025 |
| Parallel Advisors, LLC | History | Closed out | 0 | 0 | — | — | — | -100 | -100.0% | Q3 2025 | Nov 13, 2025 |
| SBI Securities Co., Ltd. | History | Reduced | 788 | 0 | — | — | — | -35 | -4.25% | Q4 2025 | Feb 03, 2026 |
| RHUMBLINE ADVISERS | History | No change | 544 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Feb 13, 2026 |
| AlphaQuest LLC | History | No change | 4,661 | 0 | — | 0.0% | — | 0 | 0.0% | Q4 2025 | Feb 09, 2026 |
| Federation des caisses Desjardins du Quebec | History | No change | 84 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Feb 12, 2026 |