BICYCLE THERAPEUTICS PLC - BCYC

Detailed investor-level table based on 13F positions.
Early Q1 2026 data: only 1 institutional holders reported so far. The full shareholder list will grow as more funds file with the SEC.

Shareholders (13F)

Quarter: Q4 2025 · Compare: Q3 2025
13D/13G major owners: Ownership tab.
Methodology: Market value and % of portfolio use SEC reported VALUE ($000). For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received. Details.
Rows: 0
Investor History Status Shares held Market value ($000) % of portfolio Previous % Rank Change in shares % change in shares Source Date reported
BAKER BROS. ADVISORS LP History No change 10,885,357 77,068 0.45% 0.61% 1 0 0.0% Q4 2025 Feb 17, 2026
FCPM III SERVICES B.V. History Added to 3,468,430 24,556 3.22% 5.34% 2 +16,100 0.47% Q4 2025 Feb 17, 2026
ARMISTICE CAPITAL, LLC History Added to 3,236,000 22,910 0.27% 0.34% 3 +258,000 8.66% Q4 2025 Feb 17, 2026
WESTFIELD CAPITAL MANAGEMENT CO LP History Added to 3,016,026 21,353 0.09% 0.1% 4 +63,483 2.15% Q4 2025 Feb 11, 2026
Siren, L.L.C. History No change 2,012,752 14,250 0.43% 0.61% 5 0 0.0% Q4 2025 Feb 13, 2026
ACADIAN ASSET MANAGEMENT LLC History Added to 1,671,258 11,806 0.02% 0.02% 6 +356,702 27.13% Q4 2025 Feb 10, 2026
Long Focus Capital Management, LLC History Added to 1,633,091 11,562 0.3% 0.36% 7 +214,396 15.11% Q4 2025 Feb 17, 2026
GSK plc History New 1,529,561 10,829 1.36% 8 +1,529,561 New Q4 2025 Feb 12, 2026
Candriam S.C.A. History Added to 1,192,279 8,441 0.04% 0.05% 9 +19,892 1.7% Q4 2025 Feb 13, 2026
PRICE T ROWE ASSOCIATES INC /MD/ History Reduced 1,171,787 8,297 0.0% 0.0% 10 -213,007 -15.38% Q4 2025 Feb 17, 2026
PRINCIPAL FINANCIAL GROUP INC History Reduced 1,148,272 8,129 0.0% 0.0% 11 -130 -0.01% Q4 2025 Feb 02, 2026
BNP Paribas Asset Management Holding S.A. History New 568,225 4,023 0.0% 12 +568,225 New Q4 2025 Feb 13, 2026
RENAISSANCE TECHNOLOGIES LLC History Added to 566,600 4,011 0.01% 0.01% 13 +47,900 9.23% Q4 2025 Feb 12, 2026
SCHRODER INVESTMENT MANAGEMENT GROUP History New 584,770 3,976 0.0% 14 +584,770 New Q4 2025 Feb 13, 2026
SILVERCREST ASSET MANAGEMENT GROUP LLC History No change 476,976 3,376 0.02% 0.02% 15 0 0.0% Q4 2025 Feb 17, 2026
MORGAN STANLEY History Reduced 465,222 3,293 0.0% 0.0% 16 -357,483 -43.45% Q4 2025 Feb 13, 2026
Birchview Capital, LP History Added to 462,700 3,275 1.92% 0.9% 17 +308,700 200.45% Q4 2025 Feb 13, 2026
BlackRock, Inc. History Added to 332,889 2,356 0.0% 0.0% 18 +50,471 17.87% Q4 2025 Feb 12, 2026
MILLENNIUM MANAGEMENT LLC History Reduced 326,626 2,312 0.0% 0.0% 19 -728,120 -69.03% Q4 2025 Feb 17, 2026
CITADEL ADVISORS LLC History Added to 313,083 2,216 0.0% 0.0% 20 +124,056 65.63% Q4 2025 Feb 17, 2026
BALYASNY ASSET MANAGEMENT L.P. History New 300,000 2,124 0.0% 21 +300,000 New Q4 2025 Feb 17, 2026
Jefferies Financial Group Inc. History Reduced 297,247 2,104 0.01% 0.01% 22 -104,679 -26.04% Q4 2025 Feb 09, 2026
MOORE CAPITAL MANAGEMENT, LP History Added to 275,000 1,947 0.03% 0.01% 23 +150,000 120.0% Q4 2025 Feb 17, 2026
Palo Alto Investors LP History No change 221,071 1,565 0.22% 0.32% 24 0 0.0% Q4 2025 Feb 17, 2026
SUSQUEHANNA INTERNATIONAL GROUP, LLP History Added to 202,423 1,433 0.0% 0.0% 25 +154,694 324.11% Q4 2025 Feb 17, 2026
PINNACLE ASSOCIATES LTD History Reduced 190,480 1,348 0.02% 0.02% 26 -6,138 -3.12% Q4 2025 Feb 05, 2026
PLATINUM INVESTMENT MANAGEMENT LTD History No change 184,603 1,306 0.3% 0.09% 27 0 0.0% Q4 2025 Feb 13, 2026
Eversept Partners, LP History Reduced 178,915 1,266 0.06% 0.1% 28 -15,525 -7.98% Q4 2025 Feb 17, 2026
FLAX POND CAPITAL, LLC History New 173,633 1,229 0.91% 29 +173,633 New Q4 2025 Mar 09, 2026
TD ASSET MANAGEMENT INC History Reduced 147,992 1,047 0.0% 0.0% 30 -30,100 -16.9% Q4 2025 Feb 10, 2026
TWO SIGMA ADVISERS, LP History Reduced 146,100 1,034 0.0% 0.0% 31 -10,600 -6.76% Q4 2025 Feb 17, 2026
FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. History New 134,689 953 0.03% 32 +134,689 New Q4 2025 Feb 09, 2026
TWO SIGMA INVESTMENTS, LP History Reduced 132,032 934 0.0% 0.0% 33 -52,505 -28.45% Q4 2025 Feb 17, 2026
Rangeley Capital, LLC History Added to 132,000 934 0.78% 0.87% 34 +2,000 1.54% Q4 2025 Feb 17, 2026
MANUFACTURERS LIFE INSURANCE COMPANY, THE History New 127,863 869 0.0% 35 +127,863 New Q4 2025 Feb 13, 2026
DekaBank Deutsche Girozentrale History No change 30,000 801 0.0% 0.0% 36 0 0.0% Q4 2025 Jan 28, 2026
Walleye Capital LLC History New 111,759 791 0.0% 37 +111,759 New Q4 2025 Feb 13, 2026
BANK OF AMERICA CORP /DE/ History Reduced 96,401 682 0.0% 0.0% 38 -495,134 -83.7% Q4 2025 Feb 17, 2026
MONIMUS CAPITAL MANAGEMENT, LP History Added to 93,840 664 0.44% 0.41% 39 +8,616 10.11% Q4 2025 Feb 17, 2026
Marex Group plc History New 78,406 555 0.0% 40 +78,406 New Q4 2025 Feb 12, 2026
JANE STREET GROUP, LLC History Reduced 77,990 552 0.0% 0.0% 41 -24,469 -23.88% Q4 2025 Feb 12, 2026
Point72 Asset Management, L.P. History Reduced 76,779 543 0.0% 0.01% 42 -354,121 -82.18% Q4 2025 Feb 17, 2026
STATE STREET CORP History Reduced 70,178 496 0.0% 0.0% 43 -4,227 -5.68% Q4 2025 Feb 13, 2026
Nan Fung Group Holdings Ltd History No change 68,943 488 0.44% 0.89% 44 0 0.0% Q4 2025 Feb 13, 2026
DAFNA Capital Management LLC History No change 64,492 456 0.11% 0.12% 45 0 0.0% Q4 2025 Feb 17, 2026
State of Tennessee, Department of Treasury History Added to 61,153 392 0.0% 0.0% 46 +16,311 36.37% Q4 2025 Feb 18, 2026
SEI INVESTMENTS CO History No change 49,056 347 0.0% 0.0% 47 0 0.0% Q4 2025 Feb 13, 2026
XTX Topco Ltd History Added to 47,674 337 0.01% 0.0% 48 +36,026 309.29% Q4 2025 Feb 17, 2026
Quadrature Capital Ltd History Added to 46,728 330 0.0% 0.0% 49 +18,834 67.52% Q4 2025 Feb 17, 2026
Man Group plc History Added to 42,860 303 0.0% 0.0% 50 +1,969 4.82% Q4 2025 Feb 17, 2026
ALPS ADVISORS INC History Added to 40,995 290 0.0% 0.0% 51 +16,872 69.94% Q4 2025 Feb 12, 2026
HARBOR CAPITAL ADVISORS, INC. History Reduced 40,486 287 0.02% 0.02% 52 -882 -2.13% Q4 2025 Jan 20, 2026
MARSHALL WACE, LLP History New 38,795 274 0.0% 53 +38,795 New Q4 2025 Feb 13, 2026
Virtus Investment Advisers, LLC History Added to 35,709 252 0.07% 0.03% 54 +22,615 172.71% Q4 2025 Feb 17, 2026
Jump Financial, LLC History Added to 31,000 219 0.0% 0.0% 55 +9,579 44.72% Q4 2025 Feb 17, 2026
WOODSTOCK CORP History Added to 29,146 206 0.02% 0.02% 56 +5,219 21.81% Q4 2025 Jan 14, 2026
UBS Group AG History Added to 25,676 181 0.0% 0.0% 57 +14,303 125.76% Q4 2025 Jan 29, 2026
GEODE CAPITAL MANAGEMENT, LLC History Reduced 25,129 177 0.0% 0.0% 58 -14,796 -37.06% Q4 2025 Feb 09, 2026
GOLDMAN SACHS GROUP INC History New 24,732 175 0.0% 59 +24,732 New Q4 2025 Mar 25, 2026
Engineers Gate Manager LP History Added to 24,047 170 0.0% 0.0% 60 +10,626 79.17% Q4 2025 Feb 17, 2026
D. E. Shaw & Co., Inc. History New 21,548 152 0.0% 61 +21,548 New Q4 2025 Feb 17, 2026
State of New Jersey Common Pension Fund D History No change 20,105 142 0.0% 0.0% 62 0 0.0% Q4 2025 Jan 30, 2026
SIMPLEX TRADING, LLC History New 19,986 141 0.0% 63 +19,986 New Q4 2025 Feb 11, 2026
FOX RUN MANAGEMENT, L.L.C. History New 19,771 139 0.02% 64 +19,771 New Q4 2025 Feb 11, 2026
Aquatic Capital Management LLC History New 18,817 133 0.0% 65 +18,817 New Q4 2025 Feb 17, 2026
JPMORGAN CHASE & CO History Added to 18,355 129 0.0% 0.0% 66 +10,228 125.85% Q4 2025 Feb 11, 2026
PORTLAND INVESTMENT COUNSEL INC. History No change 15,000 106 0.03% 0.03% 67 0 0.0% Q4 2025 Feb 12, 2026
Federation des caisses Desjardins du Quebec History No change 14,302 101 0.0% 0.0% 68 0 0.0% Q4 2025 Feb 12, 2026
PNC FINANCIAL SERVICES GROUP, INC. History Added to 14,138 100 0.0% 0.0% 69 +1,058 8.09% Q4 2025 Feb 06, 2026
HORIZON KINETICS ASSET MANAGEMENT LLC History Reduced 13,792 97 0.0% 0.0% 70 -604 -4.2% Q4 2025 Feb 11, 2026
Forefront Analytics, LLC History New 13,371 94 0.08% 72 +13,371 New Q4 2025 Feb 17, 2026
Cerity Partners LLC History Reduced 13,350 94 0.0% 0.0% 71 -1,000 -6.97% Q4 2025 Feb 11, 2026
Erste Asset Management GmbH History No change 14,000 94 0.0% 0.0% 73 0 0.0% Q4 2025 Feb 11, 2026
Vanguard Personalized Indexing Management, LLC History Reduced 12,776 90 0.0% 0.0% 74 -177 -1.37% Q4 2025 Feb 13, 2026
TOCQUEVILLE ASSET MANAGEMENT L.P. History Added to 12,600 89 0.0% 0.0% 75 +300 2.44% Q4 2025 Feb 12, 2026
RAYMOND JAMES FINANCIAL INC History New 12,336 87 0.0% 76 +12,336 New Q4 2025 Feb 18, 2026
Crossmark Global Holdings, Inc. History Added to 11,399 80 0.0% 0.0% 77 +9 0.08% Q4 2025 Feb 03, 2026
RHUMBLINE ADVISERS History Added to 11,171 79 0.0% 0.0% 78 +7,896 241.1% Q4 2025 Feb 13, 2026
ROYAL BANK OF CANADA History New 10,682 76 0.0% 79 +10,682 New Q4 2025 Feb 17, 2026
Invesco Ltd. History New 10,092 71 0.0% 80 +10,092 New Q4 2025 Feb 19, 2026
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS History No change 10,116 71 0.0% 0.0% 81 0 0.0% Q4 2025 Feb 10, 2026
Vontobel Holding Ltd. History New 10,000 70 0.0% 82 +10,000 New Q4 2025 Feb 13, 2026
Pinnacle Wealth Management Advisory Group, LLC History New 10,000 70 0.0% 83 +10,000 New Q4 2025 Feb 02, 2026
Brooklyn Investment Group History New 10,216 69 0.0% 84 +10,216 New Q4 2025 Feb 12, 2026
Legal & General Group Plc History Reduced 9,054 64 0.0% 0.0% 85 -188,863 -95.43% Q4 2025 Feb 09, 2026
FNY Investment Advisers, LLC History Reduced 7,643 54 0.02% 0.03% 86 -2,997 -28.17% Q4 2025 Jan 16, 2026
China Universal Asset Management Co., Ltd. History Reduced 7,540 53 0.0% 0.01% 87 -564 -6.96% Q4 2025 Jan 29, 2026
Clearstead Advisors, LLC History Added to 4,655 32 0.0% 0.0% 88 +3,262 234.17% Q4 2025 Feb 09, 2026
NATIXIS History Added to 4,645 31 0.0% 0.0% 89 +2,698 138.57% Q4 2025 Feb 13, 2026
ASSETMARK, INC History Added to 3,628 25 0.0% 0.0% 90 +3 0.08% Q4 2025 Jan 23, 2026
Mirae Asset Global Investments Co., Ltd. History Added to 2,248 15 0.0% 0.0% 91 +461 25.8% Q4 2025 Jan 26, 2026
Tower Research Capital LLC (TRC) History Added to 1,668 11 0.0% 0.0% 92 +3 0.18% Q4 2025 Feb 17, 2026
CITIGROUP INC History Reduced 1,291 9 0.0% 0.0% 93 -1,310 -50.37% Q4 2025 Feb 13, 2026
GAMMA Investing LLC History Reduced 1,386 9 0.0% 0.0% 94 -730 -34.5% Q4 2025 Jan 05, 2026
BNP PARIBAS FINANCIAL MARKETS History Added to 1,116 7 0.0% 0.0% 95 +305 37.61% Q4 2025 Feb 10, 2026
GF FUND MANAGEMENT CO. LTD. History Reduced 909 6 0.0% 0.0% 96 -86 -8.64% Q4 2025 Jan 27, 2026
BARCLAYS PLC History Reduced 562 3 0.0% 0.0% 97 -1,710 -75.26% Q4 2025 Feb 13, 2026
HighMark Wealth Management LLC History No change 435 3 0.0% 0.0% 98 0 0.0% Q4 2025 Feb 05, 2026
FMR LLC History No change 316 2 0.0% 0.0% 99 0 0.0% Q4 2025 Feb 17, 2026
Farther Finance Advisors, LLC History New 218 1 0.0% 104 +218 New Q4 2025 Jan 23, 2026
WELLS FARGO & COMPANY/MN History No change 200 1 0.0% 0.0% 100 0 0.0% Q4 2025 Feb 13, 2026
JONES FINANCIAL COMPANIES LLLP History No change 250 1 0.0% 0.0% 101 0 0.0% Q4 2025 Feb 17, 2026
Daiwa Securities Group Inc. History No change 103 1 0.0% 0.0% 102 0 0.0% Q4 2025 Feb 11, 2026
Winch Advisory Services, LLC History No change 172 1 0.0% 0.0% 103 0 0.0% Q4 2025 Feb 03, 2026
Handelsbanken Fonder AB History Closed out 0 0 0.0% -150,000 -100.0% Q3 2025 Nov 12, 2025
Dynamic Technology Lab Private Ltd History Closed out 0 0 0.04% -27,959 -100.0% Q3 2025 Nov 13, 2025
AMERIPRISE FINANCIAL INC History Closed out 0 0 0.0% -14,972 -100.0% Q3 2025 Nov 14, 2025
Squarepoint Ops LLC History Closed out 0 0 0.0% -13,259 -100.0% Q3 2025 Nov 14, 2025
Walleye Trading LLC History Closed out 0 0 0.0% -12,830 -100.0% Q3 2025 Nov 14, 2025
Graham Capital Management, L.P. History Closed out 0 0 0.0% -12,375 -100.0% Q3 2025 Nov 14, 2025
Manchester Capital Management LLC History Closed out 0 0 0.0% -590 -100.0% Q3 2025 Nov 14, 2025
TOTH FINANCIAL ADVISORY CORP History Closed out 0 0 0.0% -150 -100.0% Q3 2025 Oct 09, 2025
Arax Advisory Partners History New 29 0 +29 New Q4 2025 Feb 13, 2026
PRINCIPAL SECURITIES, INC. History Closed out 0 0 -18 -100.0% Q3 2025 Nov 12, 2025
OSAIC HOLDINGS, INC. History Closed out 0 0 -18 -100.0% Q3 2025 Nov 14, 2025
Blue Trust, Inc. History Closed out 0 0 -11 -100.0% Q3 2025 Oct 16, 2025
SBI Securities Co., Ltd. History Reduced 6 0 -1 -14.29% Q4 2025 Feb 03, 2026
EverSource Wealth Advisors, LLC History No change 6 0 0 0.0% Q4 2025 Feb 06, 2026
Rockefeller Capital Management L.P. History No change 5 0 0 0.0% Q4 2025 Mar 16, 2026
Caitlin John, LLC History No change 2 0 0 0.0% Q4 2025 Feb 18, 2026