BICYCLE THERAPEUTICS PLC - BCYC
Detailed investor-level table based on 13F positions.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | History | No change | 10,885,357 | 50,508 | 0.29% | 0.45% | 1 | 0 | 0.0% | Q1 2026 | May 15, 2026 |
| FCPM III SERVICES B.V. | History | No change | 3,468,430 | 16,093 | 2.23% | 3.22% | 2 | 0 | 0.0% | Q1 2026 | May 15, 2026 |
| ARMISTICE CAPITAL, LLC | History | Added to | 3,398,000 | 15,766 | 0.28% | 0.27% | 3 | +162,000 | 5.01% | Q1 2026 | May 15, 2026 |
| Long Focus Capital Management, LLC | History | Added to | 3,310,687 | 15,361 | 0.4% | 0.3% | 4 | +1,677,596 | 102.73% | Q1 2026 | May 15, 2026 |
| ACADIAN ASSET MANAGEMENT LLC | History | Added to | 1,968,025 | 9,111 | 0.01% | 0.02% | 5 | +296,767 | 17.76% | Q1 2026 | May 13, 2026 |
| Siren, L.L.C. | History | Reduced | 1,560,882 | 7,242 | 0.2% | 0.43% | 6 | -451,870 | -22.45% | Q1 2026 | May 14, 2026 |
| GSK plc | History | No change | 1,529,561 | 7,097 | 1.18% | 1.36% | 7 | 0 | 0.0% | Q1 2026 | May 14, 2026 |
| PRINCIPAL FINANCIAL GROUP INC | History | Added to | 1,174,625 | 5,450 | 0.0% | 0.0% | 8 | +26,353 | 2.3% | Q1 2026 | May 04, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | History | Reduced | 1,028,243 | 4,772 | 0.0% | 0.0% | 9 | -143,544 | -12.25% | Q1 2026 | May 15, 2026 |
| RENAISSANCE TECHNOLOGIES LLC | History | Added to | 979,300 | 4,543 | 0.01% | 0.01% | 10 | +412,700 | 72.84% | Q1 2026 | May 14, 2026 |
| MORGAN STANLEY | History | Added to | 618,327 | 2,869 | 0.0% | 0.0% | 11 | +153,105 | 32.91% | Q1 2026 | May 15, 2026 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | History | Added to | 615,833 | 2,672 | 0.0% | 0.0% | 12 | +31,063 | 5.31% | Q1 2026 | May 14, 2026 |
| DIADEMA PARTNERS LP | History | New | 476,424 | 2,210 | 0.38% | — | 13 | +476,424 | New | Q1 2026 | May 15, 2026 |
| Birchview Capital, LP | History | Added to | 463,599 | 2,151 | 1.22% | 1.92% | 14 | +899 | 0.19% | Q1 2026 | May 15, 2026 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | History | Reduced | 428,684 | 1,989 | 0.01% | 0.02% | 15 | -48,292 | -10.12% | Q1 2026 | May 15, 2026 |
| CITADEL ADVISORS LLC | History | Added to | 410,685 | 1,905 | 0.0% | 0.0% | 16 | +97,602 | 31.17% | Q1 2026 | May 15, 2026 |
| MARSHALL WACE, LLP | History | Added to | 377,335 | 1,750 | 0.0% | 0.0% | 17 | +338,540 | 872.64% | Q1 2026 | May 14, 2026 |
| Qube Research & Technologies Ltd | History | New | 308,617 | 1,431 | 0.0% | — | 18 | +308,617 | New | Q1 2026 | May 15, 2026 |
| JANE STREET GROUP, LLC | History | Added to | 303,015 | 1,405 | 0.0% | 0.0% | 19 | +225,025 | 288.53% | Q1 2026 | May 12, 2026 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | History | Added to | 296,788 | 1,377 | 0.0% | 0.0% | 20 | +94,365 | 46.62% | Q1 2026 | May 15, 2026 |
| MILLENNIUM MANAGEMENT LLC | History | Reduced | 283,986 | 1,317 | 0.0% | 0.0% | 21 | -42,640 | -13.05% | Q1 2026 | May 15, 2026 |
| BlackRock, Inc. | History | Reduced | 278,992 | 1,294 | 0.0% | 0.0% | 22 | -53,897 | -16.19% | Q1 2026 | May 13, 2026 |
| MOORE CAPITAL MANAGEMENT, LP | History | No change | 275,000 | 1,276 | 0.03% | 0.03% | 23 | 0 | 0.0% | Q1 2026 | May 15, 2026 |
| Rangeley Capital, LLC | History | Added to | 232,260 | 1,077 | 1.05% | 0.78% | 24 | +100,260 | 75.95% | Q1 2026 | May 15, 2026 |
| TWO SIGMA ADVISERS, LP | History | No change | 146,100 | 1,034 | 0.0% | 0.0% | 25 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| Palo Alto Investors LP | History | Reduced | 201,890 | 936 | 0.14% | 0.22% | 26 | -19,181 | -8.68% | Q1 2026 | May 15, 2026 |
| Eversept Partners, LP | History | Added to | 190,715 | 884 | 0.05% | 0.06% | 27 | +11,800 | 6.6% | Q1 2026 | May 15, 2026 |
| PINNACLE ASSOCIATES LTD | History | Reduced | 185,410 | 860 | 0.01% | 0.02% | 28 | -5,070 | -2.66% | Q1 2026 | Apr 21, 2026 |
| PLATINUM INVESTMENT MANAGEMENT LTD | History | No change | 184,603 | 856 | 0.22% | 0.3% | 29 | 0 | 0.0% | Q1 2026 | May 13, 2026 |
| FLAX POND CAPITAL, LLC | History | Added to | 176,136 | 817 | 0.66% | 0.91% | 30 | +2,503 | 1.44% | Q1 2026 | May 19, 2026 |
| TWO SIGMA INVESTMENTS, LP | History | Added to | 164,800 | 764 | 0.0% | 0.0% | 31 | +32,768 | 24.82% | Q1 2026 | May 15, 2026 |
| Point72 Asset Management, L.P. | History | Added to | 130,422 | 605 | 0.0% | 0.0% | 32 | +53,643 | 69.87% | Q1 2026 | May 15, 2026 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | History | No change | 127,863 | 593 | 0.0% | 0.0% | 33 | 0 | 0.0% | Q1 2026 | May 15, 2026 |
| Persistent Asset Partners Ltd | History | New | 120,437 | 558 | 0.21% | — | 34 | +120,437 | New | Q1 2026 | May 12, 2026 |
| Peapod Lane Capital LLC | History | New | 121,106 | 550 | 0.45% | — | 35 | +121,106 | New | Q1 2026 | May 01, 2026 |
| Marex Group plc | History | Added to | 115,000 | 533 | 0.0% | 0.0% | 36 | +36,594 | 46.67% | Q1 2026 | May 13, 2026 |
| GOLDMAN SACHS GROUP INC | History | Added to | 110,147 | 511 | 0.0% | 0.0% | 37 | +85,415 | 345.36% | Q1 2026 | May 15, 2026 |
| XTX Topco Ltd | History | Added to | 106,392 | 493 | 0.01% | 0.01% | 38 | +58,718 | 123.17% | Q1 2026 | May 15, 2026 |
| TD ASSET MANAGEMENT INC | History | Reduced | 91,992 | 426 | 0.0% | 0.0% | 39 | -56,000 | -37.84% | Q1 2026 | May 11, 2026 |
| ADAR1 Capital Management, LLC | History | New | 71,298 | 330 | 0.02% | — | 40 | +71,298 | New | Q1 2026 | May 15, 2026 |
| DAFNA Capital Management LLC | History | No change | 64,492 | 299 | 0.07% | 0.11% | 41 | 0 | 0.0% | Q1 2026 | May 15, 2026 |
| EntryPoint Capital, LLC | History | New | 63,906 | 296 | 0.09% | — | 42 | +63,906 | New | Q1 2026 | May 14, 2026 |
| Man Group plc | History | Added to | 63,305 | 293 | 0.0% | 0.0% | 43 | +20,445 | 47.7% | Q1 2026 | May 15, 2026 |
| AXQ CAPITAL, LP | History | New | 63,134 | 292 | 0.04% | — | 44 | +63,134 | New | Q1 2026 | May 13, 2026 |
| State of Tennessee, Department of Treasury | History | No change | 61,153 | 283 | 0.0% | 0.0% | 45 | 0 | 0.0% | Q1 2026 | May 15, 2026 |
| SEI INVESTMENTS CO | History | Added to | 52,784 | 244 | 0.0% | 0.0% | 46 | +3,728 | 7.6% | Q1 2026 | May 13, 2026 |
| Jump Financial, LLC | History | Added to | 52,544 | 243 | 0.0% | 0.0% | 47 | +21,544 | 69.5% | Q1 2026 | May 14, 2026 |
| HRT FINANCIAL LP | History | New | 45,915 | 213 | 0.0% | — | 48 | +45,915 | New | Q1 2026 | May 14, 2026 |
| ALPS ADVISORS INC | History | Reduced | 40,651 | 188 | 0.0% | 0.0% | 49 | -344 | -0.84% | Q1 2026 | May 08, 2026 |
| Virtus Investment Advisers, LLC | History | Added to | 36,601 | 169 | 0.05% | 0.07% | 50 | +892 | 2.5% | Q1 2026 | May 14, 2026 |
| Engineers Gate Manager LP | History | Added to | 35,400 | 164 | 0.0% | 0.0% | 51 | +11,353 | 47.21% | Q1 2026 | May 15, 2026 |
| UBS Group AG | History | Added to | 32,159 | 149 | 0.0% | 0.0% | 52 | +6,483 | 25.25% | Q1 2026 | May 05, 2026 |
| STATE STREET CORP | History | Reduced | 30,512 | 141 | 0.0% | 0.0% | 53 | -39,666 | -56.52% | Q1 2026 | May 15, 2026 |
| WOODSTOCK CORP | History | No change | 29,146 | 135 | 0.01% | 0.02% | 54 | 0 | 0.0% | Q1 2026 | Apr 08, 2026 |
| GSA CAPITAL PARTNERS LLP | History | New | 26,842 | 125 | 0.01% | — | 55 | +26,842 | New | Q1 2026 | May 08, 2026 |
| Aquatic Capital Management LLC | History | Added to | 26,160 | 121 | 0.0% | 0.0% | 56 | +7,343 | 39.02% | Q1 2026 | May 15, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | History | No change | 25,129 | 116 | 0.0% | 0.0% | 57 | 0 | 0.0% | Q1 2026 | May 15, 2026 |
| R Squared Ltd | History | New | 21,057 | 97 | 0.05% | — | 58 | +21,057 | New | Q1 2026 | Apr 29, 2026 |
| State of New Jersey Common Pension Fund D | History | No change | 20,105 | 93 | 0.0% | 0.0% | 59 | 0 | 0.0% | Q1 2026 | May 05, 2026 |
| Vontobel Holding Ltd. | History | Added to | 20,000 | 92 | 0.0% | 0.0% | 60 | +10,000 | 100.0% | Q1 2026 | May 08, 2026 |
| Invesco Ltd. | History | Added to | 15,067 | 69 | 0.0% | 0.0% | 61 | +4,975 | 49.3% | Q1 2026 | May 12, 2026 |
| PORTLAND INVESTMENT COUNSEL INC. | History | No change | 15,000 | 69 | 0.02% | 0.03% | 62 | 0 | 0.0% | Q1 2026 | May 14, 2026 |
| STIFEL FINANCIAL CORP | History | New | 14,687 | 68 | 0.0% | — | 63 | +14,687 | New | Q1 2026 | May 12, 2026 |
| ROYAL BANK OF CANADA | History | Added to | 14,470 | 67 | 0.0% | 0.0% | 64 | +3,788 | 35.46% | Q1 2026 | May 15, 2026 |
| 49 WEALTH MANAGEMENT, LLC | History | New | 14,317 | 66 | 0.0% | — | 67 | +14,317 | New | Q1 2026 | May 13, 2026 |
| Forefront Analytics, LLC | History | Added to | 14,394 | 66 | 0.06% | 0.08% | 65 | +1,023 | 7.65% | Q1 2026 | May 13, 2026 |
| Federation des caisses Desjardins du Quebec | History | No change | 14,302 | 66 | 0.0% | 0.0% | 66 | 0 | 0.0% | Q1 2026 | May 13, 2026 |
| Cerity Partners LLC | History | Added to | 13,570 | 62 | 0.0% | 0.0% | 68 | +220 | 1.65% | Q1 2026 | May 15, 2026 |
| HORIZON KINETICS ASSET MANAGEMENT LLC | History | Reduced | 13,188 | 61 | 0.0% | 0.0% | 69 | -604 | -4.38% | Q1 2026 | May 15, 2026 |
| Erste Asset Management GmbH | History | No change | 14,000 | 60 | 0.0% | 0.0% | 70 | 0 | 0.0% | Q1 2026 | May 11, 2026 |
| RHUMBLINE ADVISERS | History | Added to | 12,571 | 58 | 0.0% | 0.0% | 71 | +1,400 | 12.53% | Q1 2026 | May 12, 2026 |
| Crossmark Global Holdings, Inc. | History | Added to | 11,408 | 52 | 0.0% | 0.0% | 72 | +9 | 0.08% | Q1 2026 | May 11, 2026 |
| TWO SIGMA SECURITIES, LLC | History | New | 10,879 | 50 | 0.01% | — | 74 | +10,879 | New | Q1 2026 | May 15, 2026 |
| Pinnacle Wealth Management Advisory Group, LLC | History | Added to | 10,985 | 50 | 0.0% | 0.0% | 73 | +985 | 9.85% | Q1 2026 | Apr 21, 2026 |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | History | No change | 10,116 | 46 | 0.0% | 0.0% | 75 | 0 | 0.0% | Q1 2026 | May 01, 2026 |
| JPMORGAN CHASE & CO | History | Reduced | 9,873 | 42 | 0.0% | 0.0% | 76 | -8,482 | -46.21% | Q1 2026 | May 13, 2026 |
| Legal & General Group Plc | History | No change | 9,054 | 39 | 0.0% | 0.0% | 77 | 0 | 0.0% | Q1 2026 | May 08, 2026 |
| China Universal Asset Management Co., Ltd. | History | Added to | 8,222 | 38 | 0.0% | 0.0% | 78 | +682 | 9.05% | Q1 2026 | Apr 27, 2026 |
| FNY Investment Advisers, LLC | History | Reduced | 7,557 | 35 | 0.02% | 0.02% | 79 | -86 | -1.13% | Q1 2026 | Apr 15, 2026 |
| NATIXIS | History | No change | 4,645 | 21 | 0.0% | 0.0% | 80 | 0 | 0.0% | Q1 2026 | May 14, 2026 |
| ASSETMARK, INC | History | Added to | 4,218 | 19 | 0.0% | 0.0% | 81 | +590 | 16.26% | Q1 2026 | May 06, 2026 |
| Mirae Asset Global Investments Co., Ltd. | History | Added to | 2,417 | 11 | 0.0% | 0.0% | 82 | +169 | 7.52% | Q1 2026 | May 04, 2026 |
| BARCLAYS PLC | History | Added to | 2,357 | 10 | 0.0% | 0.0% | 83 | +1,795 | 319.4% | Q1 2026 | May 14, 2026 |
| Tower Research Capital LLC (TRC) | History | Added to | 1,966 | 9 | 0.0% | 0.0% | 84 | +298 | 17.87% | Q1 2026 | May 15, 2026 |
| CITIGROUP INC | History | Added to | 1,295 | 6 | 0.0% | 0.0% | 85 | +4 | 0.31% | Q1 2026 | May 11, 2026 |
| GAMMA Investing LLC | History | Reduced | 1,257 | 5 | 0.0% | 0.0% | 86 | -129 | -9.31% | Q1 2026 | Apr 06, 2026 |
| GF FUND MANAGEMENT CO. LTD. | History | Added to | 1,032 | 4 | 0.0% | 0.0% | 88 | +123 | 13.53% | Q1 2026 | Apr 15, 2026 |
| BNP PARIBAS FINANCIAL MARKETS | History | Reduced | 1,016 | 4 | 0.0% | 0.0% | 87 | -100 | -8.96% | Q1 2026 | May 12, 2026 |
| JONES FINANCIAL COMPANIES LLLP | History | Added to | 500 | 2 | 0.0% | 0.0% | 89 | +250 | 100.0% | Q1 2026 | May 15, 2026 |
| HighMark Wealth Management LLC | History | No change | 435 | 2 | 0.0% | 0.0% | 90 | 0 | 0.0% | Q1 2026 | May 05, 2026 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | History | Closed out | 0 | 0 | — | 0.09% | — | -3,016,026 | -100.0% | Q1 2026 | May 11, 2026 |
| Candriam S.C.A. | History | Closed out | 0 | 0 | — | 0.04% | — | -1,192,279 | -100.0% | Q1 2026 | Apr 30, 2026 |
| BNP Paribas Asset Management Holding S.A. | History | Closed out | 0 | 0 | — | 0.0% | — | -568,225 | -100.0% | Q1 2026 | May 14, 2026 |
| BALYASNY ASSET MANAGEMENT L.P. | History | Closed out | 0 | 0 | — | 0.0% | — | -300,000 | -100.0% | Q1 2026 | May 15, 2026 |
| Jefferies Financial Group Inc. | History | Closed out | 0 | 0 | — | 0.01% | — | -297,247 | -100.0% | Q1 2026 | May 07, 2026 |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | History | Reduced | 9 | 0 | — | 0.03% | — | -134,680 | -99.99% | Q1 2026 | Apr 27, 2026 |
| Walleye Capital LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -111,759 | -100.0% | Q1 2026 | May 13, 2026 |
| BANK OF AMERICA CORP /DE/ | History | Closed out | 0 | 0 | — | 0.0% | — | -96,401 | -100.0% | Q1 2026 | May 15, 2026 |
| MONIMUS CAPITAL MANAGEMENT, LP | History | Closed out | 0 | 0 | — | 0.44% | — | -93,840 | -100.0% | Q1 2026 | May 15, 2026 |
| Nan Fung Group Holdings Ltd | History | Closed out | 0 | 0 | — | 0.44% | — | -68,943 | -100.0% | Q1 2026 | May 14, 2026 |
| Quadrature Capital Ltd | History | Closed out | 0 | 0 | — | 0.0% | — | -46,728 | -100.0% | Q1 2026 | May 15, 2026 |
| HARBOR CAPITAL ADVISORS, INC. | History | Closed out | 0 | 0 | — | 0.02% | — | -40,486 | -100.0% | Q1 2026 | Apr 28, 2026 |
| DekaBank Deutsche Girozentrale | History | Closed out | 0 | 0 | — | 0.0% | — | -30,000 | -100.0% | Q1 2026 | May 07, 2026 |
| D. E. Shaw & Co., Inc. | History | Closed out | 0 | 0 | — | 0.0% | — | -21,548 | -100.0% | Q1 2026 | May 15, 2026 |
| SIMPLEX TRADING, LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -19,986 | -100.0% | Q1 2026 | May 14, 2026 |
| FOX RUN MANAGEMENT, L.L.C. | History | Closed out | 0 | 0 | — | 0.02% | — | -19,771 | -100.0% | Q1 2026 | May 12, 2026 |
| PNC FINANCIAL SERVICES GROUP, INC. | History | Closed out | 0 | 0 | — | 0.0% | — | -14,138 | -100.0% | Q1 2026 | May 08, 2026 |
| Vanguard Personalized Indexing Management, LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -12,776 | -100.0% | Q1 2026 | May 14, 2026 |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | History | Closed out | 0 | 0 | — | 0.0% | — | -12,600 | -100.0% | Q1 2026 | May 12, 2026 |
| RAYMOND JAMES FINANCIAL INC | History | Closed out | 0 | 0 | — | 0.0% | — | -12,336 | -100.0% | Q1 2026 | May 14, 2026 |
| Brooklyn Investment Group | History | Closed out | 0 | 0 | — | 0.0% | — | -10,216 | -100.0% | Q1 2026 | Apr 29, 2026 |
| Clearstead Advisors, LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -4,655 | -100.0% | Q1 2026 | May 06, 2026 |
| FMR LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -316 | -100.0% | Q1 2026 | May 15, 2026 |
| Farther Finance Advisors, LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -218 | -100.0% | Q1 2026 | Apr 07, 2026 |
| Daiwa Securities Group Inc. | History | Closed out | 0 | 0 | — | 0.0% | — | -103 | -100.0% | Q1 2026 | May 13, 2026 |
| Arax Advisory Partners | History | Closed out | 0 | 0 | — | — | — | -29 | -100.0% | Q1 2026 | May 13, 2026 |
| OSAIC HOLDINGS, INC. | History | New | 10 | 0 | — | — | — | +10 | New | Q1 2026 | May 15, 2026 |
| EverSource Wealth Advisors, LLC | History | Closed out | 0 | 0 | — | — | — | -6 | -100.0% | Q1 2026 | May 15, 2026 |
| Caitong International Asset Management Co., Ltd | History | New | 1 | 0 | — | — | — | +1 | New | Q1 2026 | May 11, 2026 |
| WELLS FARGO & COMPANY/MN | History | No change | 200 | 0 | — | 0.0% | — | 0 | 0.0% | Q1 2026 | May 11, 2026 |
| Winch Advisory Services, LLC | History | No change | 172 | 0 | — | 0.0% | — | 0 | 0.0% | Q1 2026 | Apr 30, 2026 |
| Rockefeller Capital Management L.P. | History | No change | 5 | 0 | — | — | — | 0 | 0.0% | Q1 2026 | May 14, 2026 |
| SBI Securities Co., Ltd. | History | No change | 6 | 0 | — | — | — | 0 | 0.0% | Q1 2026 | Apr 27, 2026 |
| Caitlin John, LLC | History | No change | 2 | 0 | — | — | — | 0 | 0.0% | Q1 2026 | May 13, 2026 |