Design Therapeutics, Inc. - DSGN
Detailed investor-level table based on 13F positions.
Early Q1 2026 data: only 1 institutional holders reported so far. The full shareholder list will grow as more funds file with the SEC.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SR ONE CAPITAL MANAGEMENT, LP | History | No change | 6,526,476 | 61,218 | 8.67% | 7.11% | 1 | 0 | 0.0% | Q4 2025 | Feb 12, 2026 |
| Point72 Asset Management, L.P. | History | Added to | 5,372,004 | 50,389 | 0.06% | 0.04% | 2 | +2,031,452 | 60.81% | Q4 2025 | Feb 17, 2026 |
| Logos Global Management LP | History | Reduced | 2,500,000 | 23,450 | 1.42% | 2.47% | 3 | -1,155,000 | -31.6% | Q4 2025 | Feb 17, 2026 |
| BAKER BROS. ADVISORS LP | History | Added to | 2,233,099 | 20,946 | 0.12% | 0.09% | 4 | +520,217 | 30.37% | Q4 2025 | Feb 17, 2026 |
| BlackRock, Inc. | History | Added to | 2,117,156 | 19,858 | 0.0% | 0.0% | 5 | +72,768 | 3.56% | Q4 2025 | Feb 12, 2026 |
| VANGUARD GROUP INC | History | Added to | 1,630,910 | 15,297 | 0.0% | 0.0% | 6 | +187,209 | 12.97% | Q4 2025 | Jan 29, 2026 |
| Vivo Capital, LLC | History | New | 1,612,903 | 15,129 | 0.98% | — | 7 | +1,612,903 | New | Q4 2025 | Feb 13, 2026 |
| Almitas Capital LLC | History | No change | 1,530,435 | 14,355 | 3.16% | 2.64% | 8 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| RA CAPITAL MANAGEMENT, L.P. | History | Added to | 1,461,381 | 13,707 | 0.14% | 0.04% | 9 | +985,682 | 207.21% | Q4 2025 | Feb 17, 2026 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | History | Added to | 1,179,817 | 11,066 | 0.08% | 0.06% | 10 | +103,581 | 9.62% | Q4 2025 | Feb 17, 2026 |
| Woodline Partners LP | History | Added to | 944,039 | 8,855 | 0.03% | 0.02% | 11 | +331,327 | 54.08% | Q4 2025 | Feb 17, 2026 |
| Kynam Capital Management, LP | History | Reduced | 784,606 | 7,359 | 0.47% | 0.58% | 12 | -244,973 | -23.79% | Q4 2025 | Feb 17, 2026 |
| FMR LLC | History | Added to | 771,268 | 7,234 | 0.0% | 0.0% | 13 | +30,419 | 4.11% | Q4 2025 | Feb 17, 2026 |
| MORGAN STANLEY | History | Added to | 702,306 | 6,587 | 0.0% | 0.0% | 14 | +526,315 | 299.06% | Q4 2025 | Feb 13, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | History | Reduced | 679,590 | 6,375 | 0.0% | 0.0% | 15 | -16,023 | -2.3% | Q4 2025 | Feb 09, 2026 |
| STATE STREET CORP | History | Added to | 647,636 | 6,074 | 0.0% | 0.0% | 16 | +13,239 | 2.09% | Q4 2025 | Feb 13, 2026 |
| ACADIAN ASSET MANAGEMENT LLC | History | Reduced | 612,768 | 5,742 | 0.01% | 0.01% | 17 | -4,721 | -0.76% | Q4 2025 | Feb 10, 2026 |
| Frazier Life Sciences Management, L.P. | History | Reduced | 521,000 | 4,886 | 0.13% | 0.44% | 18 | -1,432,547 | -73.33% | Q4 2025 | Feb 13, 2026 |
| Caption Management, LLC | History | New | 500,000 | 4,690 | 0.03% | — | 19 | +500,000 | New | Q4 2025 | Feb 17, 2026 |
| CITADEL ADVISORS LLC | History | Reduced | 459,874 | 4,313 | 0.0% | 0.0% | 20 | -94,146 | -16.99% | Q4 2025 | Feb 17, 2026 |
| D. E. Shaw & Co., Inc. | History | Added to | 438,894 | 4,116 | 0.0% | 0.0% | 21 | +65,618 | 17.58% | Q4 2025 | Feb 17, 2026 |
| Invesco Ltd. | History | Added to | 305,757 | 2,868 | 0.0% | 0.0% | 22 | +291,168 | 1995.81% | Q4 2025 | Feb 19, 2026 |
| DIMENSIONAL FUND ADVISORS LP | History | Added to | 297,921 | 2,795 | 0.0% | 0.0% | 23 | +18,104 | 6.47% | Q4 2025 | Feb 12, 2026 |
| RENAISSANCE TECHNOLOGIES LLC | History | Added to | 287,100 | 2,692 | 0.0% | 0.0% | 24 | +12,800 | 4.67% | Q4 2025 | Feb 12, 2026 |
| NORTHERN TRUST CORP | History | Reduced | 286,572 | 2,688 | 0.0% | 0.0% | 25 | -9,957 | -3.36% | Q4 2025 | Feb 17, 2026 |
| GOLDMAN SACHS GROUP INC | History | Added to | 270,654 | 2,538 | 0.0% | 0.0% | 26 | +9,209 | 3.52% | Q4 2025 | Mar 25, 2026 |
| JANE STREET GROUP, LLC | History | Added to | 237,412 | 2,226 | 0.0% | 0.0% | 27 | +119,579 | 101.48% | Q4 2025 | Feb 12, 2026 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | History | Reduced | 236,863 | 2,221 | 0.0% | 0.0% | 28 | -11,071 | -4.47% | Q4 2025 | Feb 13, 2026 |
| MARSHALL WACE, LLP | History | New | 225,528 | 2,115 | 0.0% | — | 29 | +225,528 | New | Q4 2025 | Feb 13, 2026 |
| Elmind Capital, LP | History | New | 207,900 | 1,950 | 0.58% | — | 30 | +207,900 | New | Q4 2025 | Feb 17, 2026 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | History | New | 194,611 | 1,825 | 0.01% | — | 31 | +194,611 | New | Q4 2025 | Feb 13, 2026 |
| ALGERT GLOBAL LLC | History | New | 187,769 | 1,761 | 0.03% | — | 32 | +187,769 | New | Q4 2025 | Feb 17, 2026 |
| MILLENNIUM MANAGEMENT LLC | History | Added to | 180,866 | 1,696 | 0.0% | 0.0% | 33 | +112,043 | 162.8% | Q4 2025 | Feb 17, 2026 |
| AMERIPRISE FINANCIAL INC | History | New | 158,383 | 1,485 | 0.0% | — | 34 | +158,383 | New | Q4 2025 | Feb 17, 2026 |
| ACUTA CAPITAL PARTNERS, LLC | History | New | 150,906 | 1,415 | 0.96% | — | 35 | +150,906 | New | Q4 2025 | Feb 17, 2026 |
| Nuveen, LLC | History | Reduced | 125,260 | 1,174 | 0.0% | 0.0% | 36 | -7,768 | -5.84% | Q4 2025 | Feb 12, 2026 |
| RAYMOND JAMES FINANCIAL INC | History | New | 109,763 | 1,029 | 0.0% | — | 37 | +109,763 | New | Q4 2025 | Feb 18, 2026 |
| DIADEMA PARTNERS LP | History | New | 100,320 | 941 | 0.16% | — | 38 | +100,320 | New | Q4 2025 | Feb 17, 2026 |
| Trexquant Investment LP | History | New | 99,967 | 937 | 0.01% | — | 39 | +99,967 | New | Q4 2025 | Feb 17, 2026 |
| BNP PARIBAS FINANCIAL MARKETS | History | Added to | 94,828 | 889 | 0.0% | 0.0% | 40 | +89,695 | 1747.42% | Q4 2025 | Feb 10, 2026 |
| BARCLAYS PLC | History | Reduced | 87,060 | 816 | 0.0% | 0.0% | 41 | -1,116 | -1.27% | Q4 2025 | Feb 13, 2026 |
| Bank of New York Mellon Corp | History | Reduced | 84,975 | 797 | 0.0% | 0.0% | 42 | -2,500 | -2.86% | Q4 2025 | Feb 10, 2026 |
| Informed Momentum Co LLC | History | New | 78,949 | 740 | 0.08% | — | 43 | +78,949 | New | Q4 2025 | Feb 12, 2026 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | History | Reduced | 78,500 | 736 | 0.02% | 0.03% | 44 | -109,700 | -58.29% | Q4 2025 | Feb 17, 2026 |
| Lynx1 Capital Management LP | History | Added to | 69,516 | 652 | 0.13% | 0.1% | 45 | +3,562 | 5.4% | Q4 2025 | Feb 17, 2026 |
| Palumbo Wealth Management LLC | History | Added to | 69,377 | 650 | 0.16% | 0.13% | 46 | +17,296 | 33.21% | Q4 2025 | Jan 21, 2026 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | History | Added to | 61,852 | 580 | 0.0% | 0.0% | 47 | +47,829 | 341.08% | Q4 2025 | Feb 17, 2026 |
| AMERICAN CENTURY COMPANIES INC | History | Added to | 57,798 | 542 | 0.0% | 0.0% | 48 | +6,946 | 13.66% | Q4 2025 | Feb 13, 2026 |
| CANADA PENSION PLAN INVESTMENT BOARD | History | New | 54,600 | 512 | 0.0% | — | 49 | +54,600 | New | Q4 2025 | Feb 17, 2026 |
| SEI INVESTMENTS CO | History | New | 52,730 | 494 | 0.0% | — | 50 | +52,730 | New | Q4 2025 | Feb 13, 2026 |
| STATE OF WISCONSIN INVESTMENT BOARD | History | Added to | 50,657 | 475 | 0.0% | 0.0% | 51 | +23,595 | 87.19% | Q4 2025 | Feb 17, 2026 |
| KENNEDY CAPITAL MANAGEMENT LLC | History | Added to | 50,023 | 469 | 0.01% | 0.0% | 52 | +20,612 | 70.08% | Q4 2025 | Feb 13, 2026 |
| ALPS ADVISORS INC | History | New | 46,771 | 438 | 0.0% | — | 53 | +46,771 | New | Q4 2025 | Feb 12, 2026 |
| TWO SIGMA INVESTMENTS, LP | History | Reduced | 46,237 | 433 | 0.0% | 0.0% | 54 | -13,000 | -21.95% | Q4 2025 | Feb 17, 2026 |
| Squarepoint Ops LLC | History | New | 46,142 | 432 | 0.0% | — | 56 | +46,142 | New | Q4 2025 | Feb 13, 2026 |
| ALLIANCEBERNSTEIN L.P. | History | No change | 46,120 | 432 | 0.0% | 0.0% | 55 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| PRUDENTIAL FINANCIAL INC | History | Reduced | 42,710 | 400 | 0.0% | 0.0% | 57 | -2,115 | -4.72% | Q4 2025 | Feb 13, 2026 |
| XTX Topco Ltd | History | Added to | 35,284 | 330 | 0.01% | 0.0% | 58 | +23,416 | 197.3% | Q4 2025 | Feb 17, 2026 |
| Persistent Asset Partners Ltd | History | New | 34,989 | 328 | 0.15% | — | 59 | +34,989 | New | Q4 2025 | Feb 17, 2026 |
| RHUMBLINE ADVISERS | History | Reduced | 34,778 | 326 | 0.0% | 0.0% | 60 | -11,556 | -24.94% | Q4 2025 | Feb 13, 2026 |
| China Universal Asset Management Co., Ltd. | History | Reduced | 34,282 | 321 | 0.02% | 0.02% | 61 | -700 | -2.0% | Q4 2025 | Jan 29, 2026 |
| BANK OF AMERICA CORP /DE/ | History | Added to | 27,446 | 257 | 0.0% | 0.0% | 62 | +3,539 | 14.8% | Q4 2025 | Feb 17, 2026 |
| Corient Private Wealth LLC | History | New | 26,965 | 252 | 0.0% | — | 63 | +26,965 | New | Q4 2025 | Mar 09, 2026 |
| WELLS FARGO & COMPANY/MN | History | Added to | 26,786 | 251 | 0.0% | 0.0% | 64 | +8,469 | 46.24% | Q4 2025 | Feb 13, 2026 |
| UBS Group AG | History | Added to | 25,537 | 239 | 0.0% | 0.0% | 65 | +2,844 | 12.53% | Q4 2025 | Jan 29, 2026 |
| TWO SIGMA ADVISERS, LP | History | Reduced | 25,300 | 237 | 0.0% | 0.0% | 66 | -15,200 | -37.53% | Q4 2025 | Feb 17, 2026 |
| Russell Investments Group, Ltd. | History | Added to | 25,234 | 236 | 0.0% | 0.0% | 68 | +18,857 | 295.7% | Q4 2025 | Feb 17, 2026 |
| STRS OHIO | History | Added to | 25,200 | 236 | 0.0% | 0.0% | 67 | +2,600 | 11.5% | Q4 2025 | Feb 02, 2026 |
| Virtu Financial LLC | History | New | 22,651 | 212 | 0.01% | — | 69 | +22,651 | New | Q4 2025 | Feb 23, 2026 |
| AlphaCentric Advisors LLC | History | New | 20,262 | 190 | 0.19% | — | 70 | +20,262 | New | Q4 2025 | Feb 12, 2026 |
| Baader Bank Aktiengesellschaft | History | New | 20,000 | 187 | 0.01% | — | 71 | +20,000 | New | Q4 2025 | Feb 05, 2026 |
| Velan Capital Investment Management LP | History | No change | 20,000 | 187 | 0.11% | 0.14% | 72 | 0 | 0.0% | Q4 2025 | Feb 13, 2026 |
| 9823 Capital, L.P. | History | New | 19,197 | 180 | 0.12% | — | 73 | +19,197 | New | Q4 2025 | Feb 17, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | History | Reduced | 15,711 | 148 | 0.0% | 0.0% | 74 | -603 | -3.7% | Q4 2025 | Feb 17, 2026 |
| DEUTSCHE BANK AG\ | History | New | 15,541 | 145 | 0.0% | — | 75 | +15,541 | New | Q4 2025 | Feb 11, 2026 |
| MetLife Investment Management, LLC | History | Added to | 15,249 | 143 | 0.0% | 0.0% | 76 | +4,929 | 47.76% | Q4 2025 | Feb 12, 2026 |
| JPMORGAN CHASE & CO | History | Reduced | 14,451 | 135 | 0.0% | 0.0% | 77 | -8,770 | -37.77% | Q4 2025 | Feb 11, 2026 |
| Engineers Gate Manager LP | History | New | 14,012 | 131 | 0.0% | — | 78 | +14,012 | New | Q4 2025 | Feb 17, 2026 |
| AQR CAPITAL MANAGEMENT LLC | History | Added to | 13,730 | 128 | 0.0% | 0.0% | 79 | +66 | 0.48% | Q4 2025 | Feb 17, 2026 |
| Mariner, LLC | History | Reduced | 12,822 | 119 | 0.0% | 0.0% | 80 | -3,259 | -20.27% | Q4 2025 | Feb 13, 2026 |
| AXQ CAPITAL, LP | History | New | 11,728 | 110 | 0.02% | — | 82 | +11,728 | New | Q4 2025 | Feb 10, 2026 |
| NISA INVESTMENT ADVISORS, LLC | History | No change | 11,824 | 110 | 0.0% | 0.0% | 81 | 0 | 0.0% | Q4 2025 | Jan 15, 2026 |
| TWO SIGMA SECURITIES, LLC | History | New | 11,396 | 106 | 0.01% | — | 83 | +11,396 | New | Q4 2025 | Feb 17, 2026 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | History | Added to | 11,091 | 104 | 0.0% | 0.0% | 84 | +367 | 3.42% | Q4 2025 | Feb 17, 2026 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | History | New | 7,093 | 66 | 0.0% | — | 85 | +7,093 | New | Q4 2025 | Feb 17, 2026 |
| Police & Firemen's Retirement System of New Jersey | History | No change | 6,598 | 61 | 0.0% | 0.0% | 86 | 0 | 0.0% | Q4 2025 | Feb 13, 2026 |
| Tower Research Capital LLC (TRC) | History | Added to | 4,273 | 40 | 0.0% | 0.0% | 87 | +2,314 | 118.12% | Q4 2025 | Feb 17, 2026 |
| CAZ INVESTMENTS LP | History | Reduced | 3,500 | 32 | 0.06% | 0.07% | 88 | -1,500 | -30.0% | Q4 2025 | Feb 10, 2026 |
| CITIGROUP INC | History | Added to | 3,113 | 29 | 0.0% | 0.0% | 89 | +1,523 | 95.79% | Q4 2025 | Feb 13, 2026 |
| Torren Management, LLC | History | New | 2,820 | 26 | 0.01% | — | 90 | +2,820 | New | Q4 2025 | Jan 30, 2026 |
| Mirae Asset Global Investments Co., Ltd. | History | Added to | 2,768 | 25 | 0.0% | 0.0% | 91 | +566 | 25.7% | Q4 2025 | Jan 26, 2026 |
| Ameritas Investment Partners, Inc. | History | No change | 2,570 | 24 | 0.0% | 0.0% | 92 | 0 | 0.0% | Q4 2025 | Feb 11, 2026 |
| Legal & General Group Plc | History | No change | 2,077 | 19 | 0.0% | 0.0% | 93 | 0 | 0.0% | Q4 2025 | Feb 09, 2026 |
| NEW YORK STATE COMMON RETIREMENT FUND | History | No change | 2,026 | 19 | 0.0% | 0.0% | 94 | 0 | 0.0% | Q4 2025 | Feb 12, 2026 |
| PNC FINANCIAL SERVICES GROUP, INC. | History | Reduced | 1,816 | 17 | 0.0% | 0.0% | 95 | -7 | -0.38% | Q4 2025 | Feb 06, 2026 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | History | Reduced | 1,471 | 13 | 0.0% | 0.0% | 96 | -498 | -25.29% | Q4 2025 | Feb 17, 2026 |
| Sterling Capital Management LLC | History | Reduced | 1,377 | 12 | 0.0% | 0.0% | 97 | -271 | -16.44% | Q4 2025 | Feb 13, 2026 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | History | No change | 1,227 | 11 | 0.0% | 0.0% | 98 | 0 | 0.0% | Q4 2025 | Jan 27, 2026 |
| GF FUND MANAGEMENT CO. LTD. | History | Reduced | 1,118 | 10 | 0.0% | 0.0% | 99 | -95 | -7.83% | Q4 2025 | Jan 27, 2026 |
| AMALGAMATED BANK | History | Reduced | 751 | 7 | 0.0% | 0.0% | 100 | -425 | -36.14% | Q4 2025 | Feb 05, 2026 |
| GAMMA Investing LLC | History | Added to | 750 | 7 | 0.0% | 0.0% | 101 | +307 | 69.3% | Q4 2025 | Jan 05, 2026 |
| Rockefeller Capital Management L.P. | History | New | 738 | 6 | 0.0% | — | 103 | +738 | New | Q4 2025 | Mar 16, 2026 |
| ROYAL BANK OF CANADA | History | New | 638 | 6 | 0.0% | — | 102 | +638 | New | Q4 2025 | Feb 17, 2026 |
| Clearstead Advisors, LLC | History | No change | 610 | 5 | 0.0% | 0.0% | 104 | 0 | 0.0% | Q4 2025 | Feb 09, 2026 |
| Private Wealth Management Group, LLC | History | No change | 558 | 5 | 0.0% | 0.0% | 105 | 0 | 0.0% | Q4 2025 | Jan 23, 2026 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | History | New | 380 | 3 | 0.0% | — | 106 | +380 | New | Q4 2025 | Feb 13, 2026 |
| Optiver Holding B.V. | History | No change | 328 | 3 | 0.0% | 0.0% | 107 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| Farther Finance Advisors, LLC | History | No change | 385 | 3 | 0.0% | 0.0% | 108 | 0 | 0.0% | Q4 2025 | Jan 23, 2026 |
| CWM, LLC | History | Added to | 239 | 2 | 0.0% | 0.0% | 110 | +17 | 7.66% | Q4 2025 | Jan 26, 2026 |
| MassMutual Private Wealth & Trust, FSB | History | No change | 239 | 2 | 0.0% | 0.0% | 109 | 0 | 0.0% | Q4 2025 | Jan 07, 2026 |
| Physician Wealth Advisors, Inc. | History | No change | 268 | 2 | 0.0% | 0.0% | 111 | 0 | 0.0% | Q4 2025 | Jan 29, 2026 |
| Daiwa Securities Group Inc. | History | No change | 100 | 1 | 0.0% | 0.0% | 112 | 0 | 0.0% | Q4 2025 | Feb 11, 2026 |
| TANG CAPITAL MANAGEMENT LLC | History | Closed out | 0 | 0 | — | 0.52% | — | -1,780,975 | -100.0% | Q3 2025 | Nov 14, 2025 |
| MPM BioImpact LLC | History | Closed out | 0 | 0 | — | 0.68% | — | -555,187 | -100.0% | Q3 2025 | Nov 14, 2025 |
| DLD Asset Management, LP | History | Closed out | 0 | 0 | — | 0.03% | — | -50,000 | -100.0% | Q3 2025 | Nov 14, 2025 |
| HRT FINANCIAL LP | History | Closed out | 0 | 0 | — | 0.0% | — | -31,903 | -100.0% | Q3 2025 | Nov 14, 2025 |
| SPHERA FUNDS MANAGEMENT LTD. | History | Closed out | 0 | 0 | — | 0.03% | — | -21,918 | -100.0% | Q3 2025 | Nov 14, 2025 |
| INTECH INVESTMENT MANAGEMENT LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -14,155 | -100.0% | Q3 2025 | Nov 12, 2025 |
| EverSource Wealth Advisors, LLC | History | Reduced | 3 | 0 | — | 0.0% | — | -232 | -98.72% | Q4 2025 | Feb 06, 2026 |
| Arax Advisory Partners | History | Reduced | 47 | 0 | — | 0.0% | — | -147 | -75.77% | Q4 2025 | Feb 13, 2026 |
| Rise Advisors, LLC | History | Closed out | 0 | 0 | — | — | — | -130 | -100.0% | Q3 2025 | Oct 08, 2025 |
| GROUP ONE TRADING LLC | History | Closed out | 0 | 0 | — | — | — | -100 | -100.0% | Q3 2025 | Nov 12, 2025 |
| Versant Capital Management, Inc | History | Closed out | 0 | 0 | — | — | — | -71 | -100.0% | Q3 2025 | Oct 27, 2025 |
| OSAIC HOLDINGS, INC. | History | New | 10 | 0 | — | — | — | +10 | New | Q4 2025 | Feb 17, 2026 |
| True Wealth Design, LLC | History | New | 1 | 0 | — | — | — | +1 | New | Q4 2025 | Jan 08, 2026 |
| Capital Advisors, Ltd. LLC | History | No change | 12 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Jan 21, 2026 |
| Larson Financial Group LLC | History | No change | 3 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Feb 06, 2026 |