Design Therapeutics, Inc. - DSGN

Detailed investor-level table based on 13F positions.

Shareholders (13F)

Quarter: Q1 2026 · Compare: Q4 2025
13D/13G major owners: Ownership tab.
Methodology: Market value and % of portfolio use SEC reported VALUE ($000). For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received. Details.
Rows: 0
Investor History Status Shares held Market value ($000) % of portfolio Previous % Rank Change in shares % change in shares Source Date reported
SR ONE CAPITAL MANAGEMENT, LP History No change 6,526,476 69,441 7.59% 8.67% 1 0 0.0% Q1 2026 May 14, 2026
RA CAPITAL MANAGEMENT, L.P. History Added to 2,972,973 31,632 0.34% 0.14% 2 +1,511,592 103.44% Q1 2026 May 15, 2026
Point72 Asset Management, L.P. History Reduced 2,722,754 28,970 0.04% 0.06% 3 -2,649,250 -49.32% Q1 2026 May 15, 2026
BAKER BROS. ADVISORS LP History Added to 2,585,978 27,514 0.16% 0.12% 4 +352,879 15.8% Q1 2026 May 15, 2026
BlackRock, Inc. History Added to 2,133,764 22,703 0.0% 0.0% 5 +16,608 0.78% Q1 2026 May 13, 2026
Logos Global Management LP History Reduced 1,950,000 20,748 1.04% 1.42% 6 -550,000 -22.0% Q1 2026 May 15, 2026
DRIEHAUS CAPITAL MANAGEMENT LLC History Added to 1,744,987 18,566 0.14% 0.08% 7 +565,170 47.9% Q1 2026 May 15, 2026
Vivo Capital, LLC History No change 1,612,903 17,161 1.43% 0.98% 8 0 0.0% Q1 2026 May 20, 2026
Almitas Capital LLC History Reduced 1,530,335 16,282 3.68% 3.16% 9 -100 -0.01% Q1 2026 May 15, 2026
VANGUARD GROUP INC History No change 1,630,910 15,297 0.0% 0.0% 10 0 0.0% Q4 2025 Jan 29, 2026
VANGUARD CAPITAL MANAGEMENT LLC History New 1,349,850 14,362 0.0% 11 +1,349,850 New Q1 2026 May 15, 2026
Woodline Partners LP History Added to 961,501 10,230 0.04% 0.03% 12 +17,462 1.85% Q1 2026 May 15, 2026
Trails Edge Capital Partners, LP History New 852,013 9,065 2.08% 13 +852,013 New Q1 2026 May 15, 2026
FMR LLC History Added to 798,411 8,495 0.0% 0.0% 14 +27,143 3.52% Q1 2026 May 15, 2026
Kynam Capital Management, LP History No change 784,606 8,348 0.51% 0.47% 15 0 0.0% Q1 2026 May 15, 2026
GEODE CAPITAL MANAGEMENT, LLC History Added to 692,518 7,370 0.0% 0.0% 16 +12,928 1.9% Q1 2026 May 15, 2026
STATE STREET CORP History Added to 659,575 7,017 0.0% 0.0% 17 +11,939 1.84% Q1 2026 May 15, 2026
MORGAN STANLEY History Reduced 656,565 6,985 0.0% 0.0% 18 -45,741 -6.51% Q1 2026 May 15, 2026
ACADIAN ASSET MANAGEMENT LLC History Added to 616,481 6,555 0.01% 0.01% 19 +3,713 0.61% Q1 2026 May 13, 2026
GOLDMAN SACHS GROUP INC History Added to 504,718 5,370 0.0% 0.0% 20 +234,064 86.48% Q1 2026 May 15, 2026
D. E. Shaw & Co., Inc. History Added to 470,270 5,003 0.0% 0.0% 21 +31,376 7.15% Q1 2026 May 15, 2026
DIMENSIONAL FUND ADVISORS LP History Added to 431,840 4,593 0.0% 0.0% 22 +133,919 44.95% Q1 2026 May 07, 2026
RENAISSANCE TECHNOLOGIES LLC History Added to 408,200 4,343 0.01% 0.0% 23 +121,100 42.18% Q1 2026 May 14, 2026
NORTHERN TRUST CORP History Added to 300,279 3,194 0.0% 0.0% 24 +13,707 4.78% Q1 2026 May 14, 2026
JACOBS LEVY EQUITY MANAGEMENT, INC History Added to 289,385 3,079 0.01% 0.01% 25 +94,774 48.7% Q1 2026 May 15, 2026
KENNEDY CAPITAL MANAGEMENT LLC History Added to 271,554 2,889 0.06% 0.01% 26 +221,531 442.86% Q1 2026 May 13, 2026
CHARLES SCHWAB INVESTMENT MANAGEMENT INC History Added to 241,485 2,569 0.0% 0.0% 27 +4,622 1.95% Q1 2026 May 15, 2026
CITADEL ADVISORS LLC History Reduced 231,513 2,463 0.0% 0.0% 28 -228,361 -49.66% Q1 2026 May 15, 2026
Elmind Capital, LP History No change 207,900 2,212 0.63% 0.58% 29 0 0.0% Q1 2026 May 15, 2026
ALGERT GLOBAL LLC History Added to 204,739 2,178 0.03% 0.03% 30 +16,970 9.04% Q1 2026 May 14, 2026
VANGUARD FIDUCIARY TRUST CO History New 195,658 2,081 0.0% 31 +195,658 New Q1 2026 May 08, 2026
MARSHALL WACE, LLP History Reduced 151,008 1,606 0.0% 0.0% 32 -74,520 -33.04% Q1 2026 May 14, 2026
ACUTA CAPITAL PARTNERS, LLC History Reduced 145,900 1,552 1.09% 0.96% 33 -5,006 -3.32% Q1 2026 May 15, 2026
Invesco Ltd. History Reduced 141,920 1,510 0.0% 0.0% 34 -163,837 -53.58% Q1 2026 May 12, 2026
VANGUARD PORTFOLIO MANAGEMENT LLC History New 138,565 1,474 0.0% 35 +138,565 New Q1 2026 May 08, 2026
SEI INVESTMENTS CO History Added to 133,203 1,417 0.0% 0.0% 36 +80,473 152.61% Q1 2026 May 13, 2026
Nuveen, LLC History Added to 126,815 1,349 0.0% 0.0% 37 +1,555 1.24% Q1 2026 Apr 30, 2026
Lynx1 Capital Management LP History Added to 119,516 1,271 0.2% 0.13% 38 +50,000 71.93% Q1 2026 May 01, 2026
Trexquant Investment LP History Added to 117,111 1,246 0.01% 0.01% 39 +17,144 17.15% Q1 2026 May 15, 2026
MILLENNIUM MANAGEMENT LLC History Reduced 108,928 1,158 0.0% 0.0% 40 -71,938 -39.77% Q1 2026 May 15, 2026
RAYMOND JAMES FINANCIAL INC History Reduced 108,449 1,153 0.0% 0.0% 41 -1,314 -1.2% Q1 2026 May 14, 2026
JANE STREET GROUP, LLC History Reduced 103,902 1,105 0.0% 0.0% 42 -133,510 -56.24% Q1 2026 May 12, 2026
Verdad Advisers, LP History New 92,310 982 1.11% 43 +92,310 New Q1 2026 May 15, 2026
Caption Management, LLC History Reduced 86,708 922 0.01% 0.03% 44 -413,292 -82.66% Q1 2026 May 15, 2026
Squarepoint Ops LLC History Added to 86,117 916 0.0% 0.0% 45 +39,975 86.63% Q1 2026 May 15, 2026
Bank of New York Mellon Corp History Reduced 79,645 847 0.0% 0.0% 46 -5,330 -6.27% Q1 2026 May 05, 2026
Informed Momentum Co LLC History No change 78,949 840 0.1% 0.08% 47 0 0.0% Q1 2026 May 13, 2026
Palumbo Wealth Management LLC History Added to 71,408 759 0.19% 0.16% 48 +2,031 2.93% Q1 2026 May 12, 2026
AMERICAN CENTURY COMPANIES INC History Added to 65,638 698 0.0% 0.0% 49 +7,840 13.56% Q1 2026 May 15, 2026
XTX Topco Ltd History Added to 60,939 648 0.01% 0.01% 50 +25,655 72.71% Q1 2026 May 15, 2026
CANADA PENSION PLAN INVESTMENT BOARD History Added to 60,400 642 0.0% 0.0% 51 +5,800 10.62% Q1 2026 May 15, 2026
BARCLAYS PLC History Reduced 55,790 593 0.0% 0.0% 52 -31,270 -35.92% Q1 2026 May 14, 2026
BRIDGEWAY CAPITAL MANAGEMENT, LLC History Reduced 52,000 553 0.01% 0.02% 53 -26,500 -33.76% Q1 2026 May 15, 2026
BNP PARIBAS FINANCIAL MARKETS History Reduced 50,272 534 0.0% 0.0% 54 -44,556 -46.99% Q1 2026 May 12, 2026
ALPS ADVISORS INC History Added to 50,209 534 0.0% 0.0% 55 +3,438 7.35% Q1 2026 May 08, 2026
STATE OF WISCONSIN INVESTMENT BOARD History Reduced 49,214 523 0.0% 0.0% 56 -1,443 -2.85% Q1 2026 May 15, 2026
PRUDENTIAL FINANCIAL INC History Added to 45,810 487 0.0% 0.0% 57 +3,100 7.26% Q1 2026 May 13, 2026
STRS OHIO History Added to 44,700 475 0.0% 0.0% 58 +19,500 77.38% Q1 2026 Apr 24, 2026
ALLIANCEBERNSTEIN L.P. History No change 46,120 432 0.0% 0.0% 59 0 0.0% Q1 2026 May 15, 2026
China Universal Asset Management Co., Ltd. History Added to 35,109 373 0.03% 0.02% 60 +827 2.41% Q1 2026 Apr 27, 2026
AMERIPRISE FINANCIAL INC History Reduced 34,990 372 0.0% 0.0% 61 -123,393 -77.91% Q1 2026 Jul 17, 2026
RHUMBLINE ADVISERS History Added to 34,860 370 0.0% 0.0% 62 +82 0.24% Q1 2026 May 12, 2026
Qube Research & Technologies Ltd History New 34,183 363 0.0% 63 +34,183 New Q1 2026 May 15, 2026
Corient Private Wealth LLC History Added to 27,169 289 0.0% 0.0% 64 +204 0.76% Q1 2026 May 15, 2026
AQR CAPITAL MANAGEMENT LLC History Added to 25,957 276 0.0% 0.0% 65 +12,227 89.05% Q1 2026 May 15, 2026
Russell Investments Group, Ltd. History Added to 25,437 270 0.0% 0.0% 66 +203 0.8% Q1 2026 May 08, 2026
BANK OF AMERICA CORP /DE/ History Reduced 23,264 247 0.0% 0.0% 67 -4,182 -15.24% Q1 2026 May 15, 2026
TWO SIGMA ADVISERS, LP History No change 25,300 237 0.0% 0.0% 68 0 0.0% Q4 2025 Feb 17, 2026
AlphaCentric Advisors LLC History Added to 21,231 225 0.22% 0.19% 69 +969 4.78% Q1 2026 May 07, 2026
DEUTSCHE BANK AG\ History Added to 20,644 219 0.0% 0.0% 70 +5,103 32.84% Q1 2026 May 06, 2026
Velan Capital Investment Management LP History No change 20,000 212 0.13% 0.11% 71 0 0.0% Q1 2026 May 15, 2026
UBS Group AG History Reduced 17,091 181 0.0% 0.0% 72 -8,446 -33.07% Q1 2026 May 05, 2026
PRICE T ROWE ASSOCIATES INC /MD/ History Added to 16,370 175 0.0% 0.0% 73 +659 4.19% Q1 2026 May 15, 2026
TWO SIGMA INVESTMENTS, LP History Reduced 16,300 173 0.0% 0.0% 74 -29,937 -64.75% Q1 2026 May 15, 2026
Engineers Gate Manager LP History Added to 16,090 171 0.0% 0.0% 75 +2,078 14.83% Q1 2026 May 15, 2026
Brevan Howard Capital Management LP History New 15,294 162 0.0% 77 +15,294 New Q1 2026 May 15, 2026
MetLife Investment Management, LLC History No change 15,249 162 0.0% 0.0% 76 0 0.0% Q1 2026 May 14, 2026
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO History Added to 15,193 161 0.0% 0.0% 78 +8,100 114.2% Q1 2026 May 14, 2026
NISA INVESTMENT ADVISORS, LLC History Added to 14,824 157 0.0% 0.0% 79 +3,000 25.37% Q1 2026 Apr 30, 2026
Dynamic Technology Lab Private Ltd History New 14,749 156 0.03% 80 +14,749 New Q1 2026 May 15, 2026
Quantinno Capital Management LP History New 14,128 150 0.0% 81 +14,128 New Q1 2026 May 15, 2026
JPMORGAN CHASE & CO History Reduced 14,134 146 0.0% 0.0% 82 -317 -2.19% Q1 2026 May 13, 2026
Mariner, LLC History Added to 13,066 138 0.0% 0.0% 83 +244 1.9% Q1 2026 May 13, 2026
Baader Bank Aktiengesellschaft History Reduced 12,792 136 0.01% 0.01% 84 -7,208 -36.04% Q1 2026 May 08, 2026
Vanguard Global Advisers, LLC History New 11,839 125 0.0% 86 +11,839 New Q1 2026 May 08, 2026
MIRABELLA FINANCIAL SERVICES LLP History New 11,814 125 0.01% 85 +11,814 New Q1 2026 May 12, 2026
ROYAL BANK OF CANADA History Added to 11,366 121 0.0% 0.0% 87 +10,728 1681.5% Q1 2026 May 15, 2026
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. History Added to 11,363 120 0.0% 0.0% 88 +272 2.45% Q1 2026 May 15, 2026
ADAR1 Capital Management, LLC History New 10,000 106 0.01% 89 +10,000 New Q1 2026 May 15, 2026
WELLS FARGO & COMPANY/MN History Reduced 9,027 96 0.0% 0.0% 90 -17,759 -66.3% Q1 2026 Jul 08, 2026
Police & Firemen's Retirement System of New Jersey History No change 6,598 70 0.0% 0.0% 91 0 0.0% Q1 2026 Apr 29, 2026
CITIGROUP INC History Added to 4,263 45 0.0% 0.0% 92 +1,150 36.94% Q1 2026 May 11, 2026
Rockefeller Capital Management L.P. History Added to 3,684 39 0.0% 0.0% 93 +2,946 399.19% Q1 2026 May 14, 2026
CAZ INVESTMENTS LP History No change 3,500 37 0.04% 0.06% 94 0 0.0% Q1 2026 May 12, 2026
Mirae Asset Global Investments Co., Ltd. History Added to 2,971 31 0.0% 0.0% 95 +203 7.33% Q1 2026 May 04, 2026
Ameritas Investment Partners, Inc. History No change 2,570 27 0.0% 0.0% 96 0 0.0% Q1 2026 May 13, 2026
Legal & General Group Plc History No change 2,077 22 0.0% 0.0% 97 0 0.0% Q1 2026 May 08, 2026
NEW YORK STATE COMMON RETIREMENT FUND History No change 2,026 21 0.0% 0.0% 98 0 0.0% Q1 2026 May 06, 2026
PNC FINANCIAL SERVICES GROUP, INC. History No change 1,816 19 0.0% 0.0% 99 0 0.0% Q1 2026 May 08, 2026
Tower Research Capital LLC (TRC) History Reduced 1,545 16 0.0% 0.0% 101 -2,728 -63.84% Q1 2026 May 15, 2026
Zurcher Kantonalbank (Zurich Cantonalbank) History Added to 1,594 16 0.0% 0.0% 100 +367 29.91% Q1 2026 May 15, 2026
GAMMA Investing LLC History Added to 1,472 15 0.0% 0.0% 102 +722 96.27% Q1 2026 Apr 06, 2026
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM History Reduced 1,292 13 0.0% 0.0% 103 -179 -12.17% Q1 2026 May 15, 2026
GF FUND MANAGEMENT CO. LTD. History Added to 1,271 13 0.0% 0.0% 104 +153 13.69% Q1 2026 Apr 15, 2026
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC History Added to 1,143 12 0.0% 0.0% 105 +763 200.79% Q1 2026 May 13, 2026
Sterling Capital Management LLC History Reduced 791 8 0.0% 0.0% 106 -586 -42.56% Q1 2026 Apr 22, 2026
Clearstead Advisors, LLC History No change 610 6 0.0% 0.0% 107 0 0.0% Q1 2026 May 06, 2026
Private Wealth Management Group, LLC History Reduced 533 5 0.0% 0.0% 108 -25 -4.48% Q1 2026 Apr 23, 2026
CWM, LLC History Added to 423 4 0.0% 0.0% 109 +184 76.99% Q1 2026 May 14, 2026
Farther Finance Advisors, LLC History Added to 386 4 0.0% 0.0% 110 +1 0.26% Q1 2026 Apr 07, 2026
OSAIC HOLDINGS, INC. History Added to 306 3 0.0% 111 +296 2960.0% Q1 2026 May 15, 2026
Stone House Investment Management, LLC History New 239 2 0.0% 115 +239 New Q1 2026 Apr 22, 2026
Optiver Holding B.V. History Reduced 224 2 0.0% 0.0% 114 -104 -31.71% Q1 2026 Jun 02, 2026
MassMutual Private Wealth & Trust, FSB History No change 239 2 0.0% 0.0% 112 0 0.0% Q1 2026 Apr 13, 2026
Physician Wealth Advisors, Inc. History No change 268 2 0.0% 0.0% 113 0 0.0% Q1 2026 Apr 24, 2026
Larson Financial Group LLC History Added to 181 1 0.0% 116 +178 5933.33% Q1 2026 May 15, 2026
Allworth Financial LP History New 130 1 0.0% 117 +130 New Q1 2026 May 14, 2026
Frazier Life Sciences Management, L.P. History Closed out 0 0 0.13% -521,000 -100.0% Q1 2026 May 15, 2026
DIADEMA PARTNERS LP History Closed out 0 0 0.16% -100,320 -100.0% Q1 2026 May 15, 2026
SUSQUEHANNA INTERNATIONAL GROUP, LLP History Closed out 0 0 0.0% -61,852 -100.0% Q1 2026 May 15, 2026
Persistent Asset Partners Ltd History Closed out 0 0 0.15% -34,989 -100.0% Q1 2026 May 12, 2026
Virtu Financial LLC History Closed out 0 0 0.01% -22,651 -100.0% Q1 2026 May 14, 2026
9823 Capital, L.P. History Closed out 0 0 0.12% -19,197 -100.0% Q1 2026 May 15, 2026
AXQ CAPITAL, LP History Closed out 0 0 0.02% -11,728 -100.0% Q1 2026 May 13, 2026
TWO SIGMA SECURITIES, LLC History Closed out 0 0 0.01% -11,396 -100.0% Q1 2026 May 15, 2026
Torren Management, LLC History Closed out 0 0 0.01% -2,820 -100.0% Q1 2026 Apr 30, 2026
AMALGAMATED BANK History Closed out 0 0 0.0% -751 -100.0% Q1 2026 May 08, 2026
Daiwa Securities Group Inc. History Closed out 0 0 0.0% -100 -100.0% Q1 2026 May 13, 2026
US BANCORP \DE\ History New 61 0 +61 New Q1 2026 May 14, 2026
Arax Advisory Partners History Closed out 0 0 -47 -100.0% Q1 2026 May 13, 2026
Root Financial Partners, LLC History New 38 0 +38 New Q1 2026 Apr 24, 2026
ROTHSCHILD INVESTMENT LLC History New 23 0 +23 New Q1 2026 May 07, 2026
NATIONAL BANK OF CANADA /FI/ History New 9 0 +9 New Q1 2026 May 14, 2026
MAI Capital Management History New 8 0 +8 New Q1 2026 May 15, 2026
EverSource Wealth Advisors, LLC History Added to 10 0 +7 233.33% Q1 2026 May 15, 2026
Caitong International Asset Management Co., Ltd History New 1 0 +1 New Q1 2026 May 11, 2026
Essential Partners LLC History New 1 0 +1 New Q1 2026 May 21, 2026
Capital Advisors, Ltd. LLC History No change 12 0 0 0.0% Q1 2026 Apr 16, 2026
True Wealth Design, LLC History No change 1 0 0 0.0% Q1 2026 Apr 13, 2026