MBX Biosciences, Inc. - MBX

Detailed investor-level table based on 13F positions.
Early Q1 2026 data: only 14 institutional holders reported so far. The full shareholder list will grow as more funds file with the SEC.

Shareholders (13F)

Quarter: Q4 2025 · Compare: Q3 2025
13D/13G major owners: Ownership tab.
Methodology: Market value and % of portfolio use SEC reported VALUE ($000). For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received. Details.
Rows: 0
Investor History Status Shares held Market value ($000) % of portfolio Previous % Rank Change in shares % change in shares Source Date reported
Frazier Life Sciences Management, L.P. History No change 6,652,013 209,804 5.64% 3.49% 1 0 0.0% Q4 2025 Feb 13, 2026
ORBIMED ADVISORS LLC History Reduced 3,935,203 124,116 2.53% 1.65% 2 -67,684 -1.69% Q4 2025 Feb 17, 2026
NEA Management Company, LLC History No change 3,614,486 114,000 5.81% 3.47% 3 0 0.0% Q4 2025 Feb 17, 2026
WELLINGTON MANAGEMENT GROUP LLP History Reduced 3,349,961 105,657 0.02% 0.01% 4 -1,473,375 -30.55% Q4 2025 Feb 17, 2026
Deep Track Capital, LP History Added to 3,249,790 102,498 1.83% 1.54% 5 +99,790 3.17% Q4 2025 Feb 13, 2026
BlackRock, Inc. History Added to 2,919,756 92,089 0.0% 0.0% 6 +962,295 49.16% Q4 2025 Feb 12, 2026
NVP Associates, LLC History No change 2,136,335 67,380 26.4% 22.51% 7 0 0.0% Q4 2025 Feb 17, 2026
EcoR1 Capital, LLC History No change 2,123,604 66,978 3.04% 1.78% 8 0 0.0% Q4 2025 Feb 17, 2026
VANGUARD GROUP INC History Added to 1,817,811 57,333 0.0% 0.0% 9 +140,449 8.37% Q4 2025 Jan 29, 2026
DRIEHAUS CAPITAL MANAGEMENT LLC History Reduced 1,408,159 44,413 0.3% 0.19% 10 -131,480 -8.54% Q4 2025 Feb 17, 2026
Cormorant Asset Management, LP History Reduced 1,120,000 35,324 1.63% 1.48% 11 -105,000 -8.57% Q4 2025 Feb 17, 2026
BRAIDWELL LP History New 1,018,600 32,126 1.03% 12 +1,018,600 New Q4 2025 Feb 17, 2026
Woodline Partners LP History Reduced 1,000,063 31,541 0.12% 0.1% 13 -201,087 -16.74% Q4 2025 Feb 17, 2026
Kynam Capital Management, LP History Reduced 934,799 29,483 1.88% 2.61% 14 -1,065,201 -53.26% Q4 2025 Feb 17, 2026
EVENTIDE ASSET MANAGEMENT, LLC History New 890,000 28,070 0.44% 15 +890,000 New Q4 2025 Feb 13, 2026
Parkman Healthcare Partners LLC History Added to 885,639 27,933 2.66% 1.41% 16 +112,335 14.53% Q4 2025 Feb 17, 2026
PRICE T ROWE ASSOCIATES INC /MD/ History Reduced 840,506 26,511 0.0% 0.0% 17 -114,220 -11.96% Q4 2025 Feb 17, 2026
CITADEL ADVISORS LLC History Reduced 835,357 26,347 0.0% 0.0% 18 -293,826 -26.02% Q4 2025 Feb 17, 2026
Point72 Asset Management, L.P. History Added to 680,609 21,466 0.02% 0.02% 19 +52,942 8.43% Q4 2025 Feb 17, 2026
STATE STREET CORP History Added to 672,740 21,218 0.0% 0.0% 20 +353,466 110.71% Q4 2025 Feb 13, 2026
D. E. Shaw & Co., Inc. History New 671,838 21,189 0.01% 21 +671,838 New Q4 2025 Feb 17, 2026
TCG Crossover Management, LLC History No change 650,000 20,501 0.68% 0.56% 22 0 0.0% Q4 2025 Feb 17, 2026
GEODE CAPITAL MANAGEMENT, LLC History Added to 649,391 20,486 0.0% 0.0% 23 +175,459 37.02% Q4 2025 Feb 09, 2026
MILLENNIUM MANAGEMENT LLC History Reduced 462,049 14,573 0.01% 0.01% 24 -218,367 -32.09% Q4 2025 Feb 17, 2026
Soleus Capital Management, L.P. History Added to 408,900 12,896 0.48% 0.24% 25 +133,900 48.69% Q4 2025 Feb 12, 2026
SUSQUEHANNA INTERNATIONAL GROUP, LLP History Reduced 354,428 11,178 0.0% 0.0% 26 -335,572 -48.63% Q4 2025 Feb 17, 2026
GOLDMAN SACHS GROUP INC History Reduced 331,938 10,469 0.0% 0.0% 27 -26,183 -7.31% Q4 2025 Mar 25, 2026
Trails Edge Capital Partners, LP History New 315,158 9,940 2.46% 28 +315,158 New Q4 2025 Feb 17, 2026
Rock Springs Capital Management LP History No change 282,624 8,913 0.46% 0.29% 29 0 0.0% Q4 2025 Feb 17, 2026
UBS Group AG History Added to 281,212 8,869 0.0% 0.0% 30 +220,487 363.09% Q4 2025 Jan 29, 2026
Opaleye Management Inc. History Added to 260,000 8,200 1.08% 0.63% 31 +7,000 2.77% Q4 2025 Apr 13, 2026
Affinity Asset Advisors, LLC History Added to 250,000 7,885 0.45% 0.25% 32 +85,000 51.52% Q4 2025 Feb 13, 2026
CHARLES SCHWAB INVESTMENT MANAGEMENT INC History Added to 222,180 7,007 0.0% 0.0% 33 +52,174 30.69% Q4 2025 Feb 13, 2026
Goelzer Investment Management, Inc. History New 221,672 6,991 0.32% 34 +221,672 New Q4 2025 Jan 14, 2026
Elmind Capital, LP History New 211,000 6,654 1.96% 35 +211,000 New Q4 2025 Feb 17, 2026
NORTHERN TRUST CORP History Added to 190,881 6,020 0.0% 0.0% 36 +57,616 43.23% Q4 2025 Feb 17, 2026
Schonfeld Strategic Advisors LLC History Reduced 167,125 5,271 0.02% 0.03% 37 -115,552 -40.88% Q4 2025 Feb 17, 2026
DAFNA Capital Management LLC History Added to 165,265 5,212 1.21% 0.37% 38 +80,265 94.43% Q4 2025 Feb 17, 2026
683 Capital Management, LLC History Reduced 158,800 5,008 0.22% 0.26% 39 -125,000 -44.05% Q4 2025 Feb 17, 2026
Tetragon Partners GP Ltd History Reduced 143,327 4,520 0.95% 0.42% 40 -34,513 -19.41% Q4 2025 Feb 17, 2026
TWO SIGMA INVESTMENTS, LP History Added to 138,571 4,370 0.01% 0.0% 41 +124,984 919.88% Q4 2025 Feb 17, 2026
KVP Capital Advisors, LP History New 121,524 3,832 3.71% 42 +121,524 New Q4 2025 Feb 18, 2026
BALYASNY ASSET MANAGEMENT L.P. History Added to 119,726 3,776 0.0% 0.0% 43 +94,085 366.93% Q4 2025 Feb 17, 2026
JANE STREET GROUP, LLC History Added to 103,081 3,251 0.0% 0.0% 44 +66,881 184.75% Q4 2025 Feb 12, 2026
TD ASSET MANAGEMENT INC History Reduced 101,450 3,199 0.0% 0.0% 45 -17,342 -14.6% Q4 2025 Feb 10, 2026
Burkehill Global Management, LP History No change 100,000 3,154 0.21% 0.1% 46 0 0.0% Q4 2025 Feb 17, 2026
PFM Health Sciences, LP History Reduced 79,310 2,501 0.25% 0.3% 47 -142,195 -64.19% Q4 2025 Feb 17, 2026
STEMPOINT CAPITAL LP History Added to 78,553 2,477 0.42% 0.26% 48 +3,553 4.74% Q4 2025 Feb 17, 2026
OSAIC HOLDINGS, INC. History New 77,601 2,447 0.0% 49 +77,601 New Q4 2025 Feb 17, 2026
Nuveen, LLC History Added to 75,565 2,383 0.0% 0.0% 50 +53,422 241.26% Q4 2025 Feb 12, 2026
Bank of New York Mellon Corp History Added to 75,262 2,373 0.0% 0.0% 51 +27,527 57.67% Q4 2025 Feb 10, 2026
SCHRODER INVESTMENT MANAGEMENT GROUP History New 73,736 2,278 0.0% 52 +73,736 New Q4 2025 Feb 13, 2026
Aaron Wealth Advisors LLC History Added to 70,000 2,207 0.12% 0.05% 53 +20,000 40.0% Q4 2025 Jan 21, 2026
MANUFACTURERS LIFE INSURANCE COMPANY, THE History New 69,551 2,154 0.0% 54 +69,551 New Q4 2025 Feb 13, 2026
MORGAN STANLEY History Added to 59,026 1,861 0.0% 0.0% 55 +14,158 31.55% Q4 2025 Feb 13, 2026
Verition Fund Management LLC History Added to 57,575 1,815 0.01% 0.0% 56 +46,975 443.16% Q4 2025 Feb 13, 2026
ExodusPoint Capital Management, LP History New 57,005 1,797 0.01% 57 +57,005 New Q4 2025 Feb 17, 2026
BARCLAYS PLC History Added to 52,691 1,661 0.0% 0.0% 58 +31,065 143.65% Q4 2025 Feb 13, 2026
ACADIAN ASSET MANAGEMENT LLC History Added to 48,614 1,530 0.0% 0.0% 59 +43,605 870.53% Q4 2025 Feb 10, 2026
Squarepoint Ops LLC History New 46,702 1,472 0.0% 60 +46,702 New Q4 2025 Feb 13, 2026
PLATINUM INVESTMENT MANAGEMENT LTD History Reduced 43,597 1,375 0.32% 0.08% 61 -25,831 -37.21% Q4 2025 Feb 13, 2026
BANK OF AMERICA CORP /DE/ History Added to 37,894 1,195 0.0% 0.0% 62 +11,278 42.37% Q4 2025 Feb 17, 2026
ALPS ADVISORS INC History Added to 36,872 1,162 0.01% 0.0% 63 +20,032 118.95% Q4 2025 Feb 12, 2026
Creative Planning History Added to 33,651 1,061 0.0% 0.0% 64 +4,919 17.12% Q4 2025 Feb 17, 2026
RHUMBLINE ADVISERS History Added to 33,420 1,054 0.0% 0.0% 65 +11,599 53.16% Q4 2025 Feb 13, 2026
RENAISSANCE TECHNOLOGIES LLC History New 32,644 1,029 0.0% 66 +32,644 New Q4 2025 Feb 12, 2026
WELLS FARGO & COMPANY/MN History Added to 31,931 1,007 0.0% 0.0% 67 +20,176 171.64% Q4 2025 Feb 13, 2026
AQR CAPITAL MANAGEMENT LLC History Added to 31,409 990 0.0% 0.0% 68 +15,645 99.25% Q4 2025 Feb 17, 2026
ALLIANCEBERNSTEIN L.P. History Added to 27,900 879 0.0% 0.0% 69 +17,400 165.71% Q4 2025 Feb 17, 2026
Brevan Howard Capital Management LP History New 25,663 809 0.01% 70 +25,663 New Q4 2025 Feb 17, 2026
Caption Management, LLC History Reduced 25,100 791 0.01% 0.01% 71 -69,900 -73.58% Q4 2025 Feb 17, 2026
Trexquant Investment LP History New 24,268 765 0.01% 72 +24,268 New Q4 2025 Feb 17, 2026
FOX RUN MANAGEMENT, L.L.C. History New 23,820 751 0.12% 73 +23,820 New Q4 2025 Feb 11, 2026
Qube Research & Technologies Ltd History New 23,213 732 0.0% 74 +23,213 New Q4 2025 Feb 17, 2026
Cerity Partners LLC History New 21,323 672 0.0% 75 +21,323 New Q4 2025 Feb 11, 2026
Invesco Ltd. History Added to 21,203 668 0.0% 0.0% 76 +9,415 79.87% Q4 2025 Feb 19, 2026
XTX Topco Ltd History Reduced 20,139 635 0.02% 0.03% 77 -18,239 -47.52% Q4 2025 Feb 17, 2026
DEUTSCHE BANK AG\ History Added to 20,027 631 0.0% 0.0% 78 +9,104 83.35% Q4 2025 Feb 11, 2026
GSA CAPITAL PARTNERS LLP History New 19,295 609 0.05% 79 +19,295 New Q4 2025 Feb 06, 2026
Koa Wealth Management, LLC History Reduced 18,413 580 0.4% 0.35% 80 -8,300 -31.07% Q4 2025 Jan 29, 2026
Seven Fleet Capital Management LP History New 18,200 574 0.39% 81 +18,200 New Q4 2025 Apr 02, 2026
CITIGROUP INC History Added to 16,391 516 0.0% 0.0% 82 +16,213 9108.43% Q4 2025 Feb 13, 2026
MetLife Investment Management, LLC History Added to 16,018 505 0.0% 0.0% 83 +5,000 45.38% Q4 2025 Feb 12, 2026
FMR LLC History Reduced 15,746 496 0.0% 0.0% 84 -53,230 -77.17% Q4 2025 Feb 17, 2026
China Universal Asset Management Co., Ltd. History Added to 15,317 483 0.04% 0.01% 85 +10,317 206.34% Q4 2025 Jan 29, 2026
JPMORGAN CHASE & CO History Added to 14,645 461 0.0% 0.0% 86 +8,470 137.17% Q4 2025 Feb 11, 2026
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. History Added to 13,258 418 0.0% 0.0% 87 +6,138 86.21% Q4 2025 Feb 17, 2026
AMERICAN CENTURY COMPANIES INC History New 12,236 385 0.0% 88 +12,236 New Q4 2025 Feb 13, 2026
CANADA PENSION PLAN INVESTMENT BOARD History New 11,600 365 0.0% 89 +11,600 New Q4 2025 Feb 17, 2026
Graham Capital Management, L.P. History New 11,254 354 0.01% 90 +11,254 New Q4 2025 Feb 17, 2026
BRIDGEWAY CAPITAL MANAGEMENT, LLC History Reduced 10,000 315 0.01% 0.01% 91 -4,200 -29.58% Q4 2025 Feb 17, 2026
GROUP ONE TRADING LLC History New 9,428 297 0.0% 92 +9,428 New Q4 2025 Feb 12, 2026
PROFUND ADVISORS LLC History New 9,214 290 0.01% 93 +9,214 New Q4 2025 Feb 06, 2026
SIMPLEX TRADING, LLC History New 8,925 281 0.0% 95 +8,925 New Q4 2025 Feb 11, 2026
Virtus Investment Advisers, LLC History Reduced 8,910 281 0.08% 0.05% 94 -1,704 -16.05% Q4 2025 Feb 17, 2026
Rafferty Asset Management, LLC History New 8,113 255 0.0% 96 +8,113 New Q4 2025 Feb 13, 2026
SEI INVESTMENTS CO History New 7,657 241 0.0% 97 +7,657 New Q4 2025 Feb 13, 2026
Police & Firemen's Retirement System of New Jersey History Added to 7,520 237 0.0% 0.0% 98 +3,011 66.78% Q4 2025 Feb 13, 2026
ProShare Advisors LLC History New 7,187 226 0.0% 99 +7,187 New Q4 2025 Feb 06, 2026
LOS ANGELES CAPITAL MANAGEMENT LLC History New 10,360 225 0.0% 100 +10,360 New Q4 2025 Feb 11, 2026
INTECH INVESTMENT MANAGEMENT LLC History New 6,858 216 0.0% 101 +6,858 New Q4 2025 Feb 10, 2026
BNP PARIBAS FINANCIAL MARKETS History Added to 6,784 213 0.0% 0.0% 102 +3,888 134.25% Q4 2025 Feb 10, 2026
AXQ CAPITAL, LP History New 6,463 203 0.05% 103 +6,463 New Q4 2025 Feb 10, 2026
SG Americas Securities, LLC History New 4,765 150 0.0% 104 +4,765 New Q4 2025 Jan 09, 2026
NEW YORK STATE COMMON RETIREMENT FUND History No change 4,300 135 0.0% 0.0% 105 0 0.0% Q4 2025 Feb 12, 2026
Tower Research Capital LLC (TRC) History Added to 3,416 107 0.0% 0.0% 106 +2,149 169.61% Q4 2025 Feb 17, 2026
Rockefeller Capital Management L.P. History No change 3,000 94 0.0% 0.0% 107 0 0.0% Q4 2025 Mar 16, 2026
Russell Investments Group, Ltd. History Added to 2,856 90 0.0% 0.0% 108 +1,375 92.84% Q4 2025 Feb 17, 2026
Legal & General Group Plc History Added to 2,539 80 0.0% 0.0% 109 +1,211 91.19% Q4 2025 Feb 09, 2026
Ameritas Investment Partners, Inc. History Added to 2,312 72 0.0% 0.0% 110 +1,135 96.43% Q4 2025 Feb 11, 2026
Mirae Asset Global Investments Co., Ltd. History New 2,182 68 0.0% 111 +2,182 New Q4 2025 Jan 26, 2026
CWM, LLC History Added to 1,784 56 0.0% 0.0% 112 +400 28.9% Q4 2025 Jan 26, 2026
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM History Added to 1,754 55 0.0% 0.0% 113 +689 64.69% Q4 2025 Feb 17, 2026
Sterling Capital Management LLC History Added to 1,641 51 0.0% 0.0% 114 +583 55.1% Q4 2025 Feb 13, 2026
NISA INVESTMENT ADVISORS, LLC History No change 1,592 50 0.0% 0.0% 115 0 0.0% Q4 2025 Jan 15, 2026
ROYAL BANK OF CANADA History New 1,532 49 0.0% 116 +1,532 New Q4 2025 Feb 17, 2026
AMALGAMATED BANK History Added to 895 28 0.0% 0.0% 117 +511 133.07% Q4 2025 Feb 05, 2026
GF FUND MANAGEMENT CO. LTD. History New 882 27 0.0% 118 +882 New Q4 2025 Jan 27, 2026
STRS OHIO History No change 700 22 0.0% 0.0% 119 0 0.0% Q4 2025 Feb 02, 2026
US BANCORP \DE\ History Reduced 312 9 0.0% 0.0% 120 -25 -7.42% Q4 2025 Jan 30, 2026
GAMMA Investing LLC History No change 299 9 0.0% 0.0% 121 0 0.0% Q4 2025 Jan 05, 2026
Aster Capital Management (DIFC) Ltd History New 265 8 0.0% 122 +265 New Q4 2025 Feb 17, 2026
PNC FINANCIAL SERVICES GROUP, INC. History Reduced 196 6 0.0% 0.0% 123 -56 -22.22% Q4 2025 Feb 06, 2026
Daiwa Securities Group Inc. History New 150 5 0.0% 125 +150 New Q4 2025 Feb 11, 2026
SIGNATUREFD, LLC History No change 179 5 0.0% 0.0% 124 0 0.0% Q4 2025 Jan 20, 2026
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC History New 100 3 0.0% 126 +100 New Q4 2025 Feb 13, 2026
Physician Wealth Advisors, Inc. History No change 109 3 0.0% 0.0% 127 0 0.0% Q4 2025 Jan 29, 2026
JONES FINANCIAL COMPANIES LLLP History New 80 2 0.0% 128 +80 New Q4 2025 Feb 17, 2026
Allworth Financial LP History New 52 1 0.0% 129 +52 New Q4 2025 Feb 05, 2026
Cornerstone Financial Management LLC History New 34 1 0.0% 131 +34 New Q4 2025 Feb 13, 2026
Parallel Advisors, LLC History No change 61 1 0.0% 0.0% 130 0 0.0% Q4 2025 Feb 11, 2026
FRANKLIN RESOURCES INC History Closed out 0 0 0.01% -1,307,288 -100.0% Q3 2025 Nov 13, 2025
Ikarian Capital, LLC History Closed out 0 0 0.79% -448,071 -100.0% Q3 2025 Nov 14, 2025
BAKER BROS. ADVISORS LP History Closed out 0 0 0.04% -277,777 -100.0% Q3 2025 Nov 14, 2025
Longaeva Partners L.P. History Closed out 0 0 0.57% -224,433 -100.0% Q3 2025 Nov 14, 2025
LMR Partners LLP History Closed out 0 0 0.02% -195,100 -100.0% Q3 2025 Nov 14, 2025
SECTORAL ASSET MANAGEMENT INC History Closed out 0 0 2.1% -194,898 -100.0% Q3 2025 Nov 14, 2025
BOOTHBAY FUND MANAGEMENT, LLC History Closed out 0 0 0.05% -185,098 -100.0% Q3 2025 Nov 14, 2025
DIADEMA PARTNERS LP History Closed out 0 0 0.45% -100,000 -100.0% Q3 2025 Nov 14, 2025
Hudson Bay Capital Management LP History Closed out 0 0 0.0% -85,000 -100.0% Q3 2025 Dec 15, 2025
Murchinson Ltd. History Closed out 0 0 0.18% -80,000 -100.0% Q3 2025 Nov 14, 2025
Exome Asset Management LLC History Closed out 0 0 0.56% -52,402 -100.0% Q3 2025 Nov 14, 2025
READYSTATE ASSET MANAGEMENT LP History Closed out 0 0 0.03% -38,500 -100.0% Q3 2025 Nov 07, 2025
Ghisallo Capital Management LLC History Closed out 0 0 0.02% -38,250 -100.0% Q3 2025 Nov 14, 2025
Weiss Asset Management LP History Closed out 0 0 0.19% -30,823 -100.0% Q3 2025 Feb 17, 2026
SummitTX Capital, L.P. History Closed out 0 0 0.02% -29,310 -100.0% Q3 2025 Nov 14, 2025
Universal- Beteiligungs- und Servicegesellschaft mbH History Closed out 0 0 0.0% -28,461 -100.0% Q3 2025 Oct 30, 2025
Walleye Capital LLC History Closed out 0 0 0.0% -15,176 -100.0% Q3 2025 Nov 14, 2025
SILVERARC CAPITAL MANAGEMENT, LLC History Closed out 0 0 0.04% -15,000 -100.0% Q3 2025 Nov 12, 2025
Man Group plc History Closed out 0 0 0.0% -10,225 -100.0% Q3 2025 Nov 14, 2025
Symmetry Investments LP History Closed out 0 0 0.01% -10,000 -100.0% Q3 2025 Nov 14, 2025
Quarry LP History Closed out 0 0 0.02% -6,499 -100.0% Q3 2025 Nov 14, 2025
FNY Investment Advisers, LLC History Closed out 0 0 0.01% -1,575 -100.0% Q3 2025 Dec 15, 2025
Arax Advisory Partners History Closed out 0 0 0.0% -398 -100.0% Q3 2025 Nov 14, 2025
Farther Finance Advisors, LLC History Reduced 10 0 0.0% -318 -96.95% Q4 2025 Jan 23, 2026
Washington Trust Advisors, Inc. History Closed out 0 0 0.0% -83 -100.0% Q3 2025 Nov 10, 2025
COMERICA BANK History Closed out 0 0 0.0% -76 -100.0% Q3 2025 Nov 14, 2025
Rise Advisors, LLC History Closed out 0 0 0.0% -68 -100.0% Q3 2025 Oct 08, 2025
Global Retirement Partners, LLC History New 19 0 +19 New Q4 2025 Feb 06, 2026
SBI Securities Co., Ltd. History New 9 0 +9 New Q4 2025 Feb 03, 2026
ROTHSCHILD INVESTMENT LLC History Added to 24 0 +4 20.0% Q4 2025 Feb 10, 2026
EverSource Wealth Advisors, LLC History Added to 25 0 +2 8.7% Q4 2025 Feb 06, 2026
True Wealth Design, LLC History New 2 0 +2 New Q4 2025 Jan 08, 2026
IFP Advisors, Inc History New 1 0 +1 New Q4 2025 Feb 06, 2026