Orchestra BioMed Holdings, Inc. - OBIO

Detailed investor-level table based on 13F positions.

Shareholders (13F)

Quarter: Q4 2025 · Compare: Q3 2025
13D/13G major owners: Ownership tab.
Methodology: Market value and % of portfolio use SEC reported VALUE ($000). For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received. Details.
Rows: 0
Investor History Status Shares held Market value ($000) % of portfolio Previous % Rank Change in shares % change in shares Source Date reported
RTW INVESTMENTS, LP History New 8,306,063 34,470 0.35% 1 +8,306,063 New Q4 2025 Feb 17, 2026
PERCEPTIVE ADVISORS LLC History Reduced 5,127,256 21,278 0.38% 0.38% 2 -165,300 -3.12% Q4 2025 Feb 17, 2026
VANGUARD GROUP INC History Added to 1,604,556 6,658 0.0% 0.0% 3 +122,681 8.28% Q4 2025 Jan 29, 2026
Alyeska Investment Group, L.P. History Reduced 1,000,000 4,150 0.01% 0.01% 4 -365,482 -26.77% Q4 2025 Feb 13, 2026
BlackRock, Inc. History Reduced 630,901 2,618 0.0% 0.0% 5 -33,432 -5.03% Q4 2025 Feb 12, 2026
Affinity Asset Advisors, LLC History Reduced 572,804 2,377 0.14% 0.16% 6 -154,468 -21.24% Q4 2025 Feb 13, 2026
GEODE CAPITAL MANAGEMENT, LLC History Added to 473,363 1,965 0.0% 0.0% 7 +86,564 22.38% Q4 2025 Feb 09, 2026
PRICE T ROWE ASSOCIATES INC /MD/ History Reduced 364,645 1,514 0.0% 0.0% 8 -56,967 -13.51% Q4 2025 Feb 17, 2026
CHARLES SCHWAB INVESTMENT MANAGEMENT INC History Added to 263,788 1,094 0.0% 0.0% 9 +83,349 46.19% Q4 2025 Feb 13, 2026
Knott David M Jr History Added to 250,000 1,037 0.48% 0.19% 10 +55,000 28.21% Q4 2025 Feb 12, 2026
MILLENNIUM MANAGEMENT LLC History Reduced 243,473 1,010 0.0% 0.0% 11 -130,514 -34.9% Q4 2025 Feb 17, 2026
683 Capital Management, LLC History New 204,076 846 0.04% 12 +204,076 New Q4 2025 Feb 17, 2026
JANE STREET GROUP, LLC History Added to 187,665 778 0.0% 0.0% 13 +122,141 186.41% Q4 2025 Feb 12, 2026
MARSHALL WACE, LLP History New 171,681 712 0.0% 14 +171,681 New Q4 2025 Feb 13, 2026
Point72 Asset Management, L.P. History New 161,946 672 0.0% 15 +161,946 New Q4 2025 Feb 17, 2026
STATE STREET CORP History Added to 159,033 659 0.0% 0.0% 16 +58,300 57.88% Q4 2025 Feb 13, 2026
SUSQUEHANNA INTERNATIONAL GROUP, LLP History Reduced 155,130 643 0.0% 0.0% 17 -3,075 -1.94% Q4 2025 Feb 17, 2026
RENAISSANCE TECHNOLOGIES LLC History Reduced 151,300 627 0.0% 0.0% 18 -229,208 -60.24% Q4 2025 Feb 12, 2026
GOLDMAN SACHS GROUP INC History Added to 134,073 556 0.0% 0.0% 19 +110,443 467.38% Q4 2025 Mar 25, 2026
DAFNA Capital Management LLC History Reduced 126,841 526 0.12% 0.22% 20 -236,795 -65.12% Q4 2025 Feb 17, 2026
NORTHERN TRUST CORP History Added to 110,899 460 0.0% 0.0% 21 +8,327 8.12% Q4 2025 Feb 17, 2026
Qube Research & Technologies Ltd History Added to 106,742 442 0.0% 0.0% 22 +80,808 311.59% Q4 2025 Feb 17, 2026
ExodusPoint Capital Management, LP History New 95,635 396 0.0% 23 +95,635 New Q4 2025 Feb 17, 2026
BARCLAYS PLC History Added to 94,517 392 0.0% 24 +94,516 9451600.0% Q4 2025 Feb 13, 2026
TWO SIGMA INVESTMENTS, LP History New 86,552 359 0.0% 25 +86,552 New Q4 2025 Feb 17, 2026
IFP Advisors, Inc History No change 86,698 359 0.01% 0.01% 26 0 0.0% Q4 2025 Feb 06, 2026
MORGAN STANLEY History Added to 81,851 339 0.0% 0.0% 27 +71,528 692.9% Q4 2025 Feb 13, 2026
CITADEL ADVISORS LLC History Added to 70,975 294 0.0% 0.0% 28 +16,973 31.43% Q4 2025 Feb 17, 2026
OMERS ADMINISTRATION Corp History New 67,100 278 0.0% 29 +67,100 New Q4 2025 Feb 13, 2026
Holos Integrated Wealth LLC History No change 51,595 222 0.12% 0.1% 30 0 0.0% Q4 2025 Jan 05, 2026
XTX Topco Ltd History Added to 50,358 208 0.01% 0.0% 31 +15,540 44.63% Q4 2025 Feb 17, 2026
Hudson Bay Capital Management LP History New 49,425 205 0.0% 32 +49,425 New Q4 2025 Feb 13, 2026
TD ASSET MANAGEMENT INC History Reduced 45,692 189 0.0% 0.0% 33 -46,986 -50.7% Q4 2025 Feb 10, 2026
Squarepoint Ops LLC History New 44,343 184 0.0% 34 +44,343 New Q4 2025 Feb 13, 2026
NewEdge Advisors, LLC History No change 44,083 182 0.0% 0.0% 35 0 0.0% Q4 2025 Feb 18, 2026
MANUFACTURERS LIFE INSURANCE COMPANY, THE History New 32,518 134 0.0% 36 +32,518 New Q4 2025 Feb 13, 2026
Meramec Financial Planners, LLC History New 30,000 117 0.05% 37 +30,000 New Q4 2025 Feb 10, 2026
TWO SIGMA ADVISERS, LP History New 27,100 112 0.0% 38 +27,100 New Q4 2025 Feb 17, 2026
Lighthouse Investment Partners, LLC History New 24,900 103 0.0% 40 +24,900 New Q4 2025 Feb 17, 2026
BRIDGEWAY CAPITAL MANAGEMENT, LLC History No change 25,000 103 0.0% 0.0% 39 0 0.0% Q4 2025 Feb 17, 2026
SIMPLEX TRADING, LLC History Added to 24,300 100 0.0% 41 +23,976 7400.0% Q4 2025 Feb 11, 2026
Daytona Street Capital LLC History New 21,500 89 0.07% 42 +21,500 New Q4 2025 Jan 21, 2026
Cresset Asset Management, LLC History New 20,000 83 0.0% 43 +20,000 New Q4 2025 Feb 17, 2026
CITIGROUP INC History Added to 19,458 80 0.0% 44 +19,417 47358.54% Q4 2025 Feb 13, 2026
BALYASNY ASSET MANAGEMENT L.P. History New 18,268 75 0.0% 45 +18,268 New Q4 2025 Feb 17, 2026
HighTower Advisors, LLC History No change 18,275 75 0.0% 0.0% 46 0 0.0% Q4 2025 Feb 06, 2026
BANK OF AMERICA CORP /DE/ History Reduced 17,547 72 0.0% 0.0% 47 -13,572 -43.61% Q4 2025 Feb 17, 2026
BNP PARIBAS FINANCIAL MARKETS History Added to 17,007 70 0.0% 0.0% 49 +16,443 2915.43% Q4 2025 Feb 10, 2026
GROUP ONE TRADING LLC History Added to 16,900 70 0.0% 0.0% 48 +6,100 56.48% Q4 2025 Feb 12, 2026
AQR CAPITAL MANAGEMENT LLC History Reduced 16,290 67 0.0% 0.0% 50 -822 -4.8% Q4 2025 Feb 17, 2026
Creative Planning History Reduced 16,290 67 0.0% 0.0% 51 -811 -4.74% Q4 2025 Feb 17, 2026
Virtu Financial LLC History New 13,623 57 0.0% 52 +13,623 New Q4 2025 Feb 23, 2026
ABLE Financial Group, LLC History No change 13,402 55 0.01% 0.01% 53 0 0.0% Q4 2025 Jan 23, 2026
UBS Group AG History Added to 11,389 47 0.0% 0.0% 54 +7,574 198.53% Q4 2025 Jan 29, 2026
GSA CAPITAL PARTNERS LLP History New 10,773 45 0.0% 55 +10,773 New Q4 2025 Feb 06, 2026
China Universal Asset Management Co., Ltd. History New 9,201 38 0.0% 56 +9,201 New Q4 2025 Jan 29, 2026
CANADA PENSION PLAN INVESTMENT BOARD History New 7,100 29 0.0% 57 +7,100 New Q4 2025 Feb 17, 2026
JPMORGAN CHASE & CO History Added to 4,586 19 0.0% 0.0% 58 +4,116 875.74% Q4 2025 Feb 11, 2026
Mirae Asset Global Investments Co., Ltd. History New 2,744 11 0.0% 59 +2,744 New Q4 2025 Jan 26, 2026
HARBOUR INVESTMENTS, INC. History No change 1,988 8 0.0% 0.0% 60 0 0.0% Q4 2025 Feb 09, 2026
GF FUND MANAGEMENT CO. LTD. History New 1,109 4 0.0% 61 +1,109 New Q4 2025 Jan 27, 2026
Tower Research Capital LLC (TRC) History New 646 2 0.0% 62 +646 New Q4 2025 Feb 17, 2026
ROYAL BANK OF CANADA History New 371 1 0.0% 63 +371 New Q4 2025 Feb 17, 2026
Optiver Holding B.V. History No change 312 1 0.0% 64 0 0.0% Q4 2025 Feb 17, 2026
Knoll Capital Management, LLC History Closed out 0 0 0.23% -455,128 -100.0% Q3 2025 Nov 14, 2025
Quadrature Capital Ltd History Closed out 0 0 0.0% -15,577 -100.0% Q3 2025 Nov 13, 2025
CWM, LLC History Closed out 0 0 -2 -100.0% Q3 2025 Oct 15, 2025
SBI Securities Co., Ltd. History No change 6 0 0 0.0% Q4 2025 Feb 03, 2026