Prelude Therapeutics Inc - PRLD

Detailed investor-level table based on 13F positions.
Early Q1 2026 data: only 1 institutional holders reported so far. The full shareholder list will grow as more funds file with the SEC.

Shareholders (13F)

Quarter: Q4 2025 · Compare: Q3 2025
13D/13G major owners: Ownership tab.
Methodology: Market value and % of portfolio use SEC reported VALUE ($000). For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received. Details.
Rows: 0
Investor History Status Shares held Market value ($000) % of portfolio Previous % Rank Change in shares % change in shares Source Date reported
ORBIMED ADVISORS LLC History No change 10,909,256 31,636 0.65% 0.37% 1 0 0.0% Q4 2025 Feb 17, 2026
BAKER BROS. ADVISORS LP History No change 10,123,824 29,359 0.17% 0.11% 2 0 0.0% Q4 2025 Feb 17, 2026
VANGUARD GROUP INC History Added to 1,413,986 4,100 0.0% 0.0% 3 +421,132 42.42% Q4 2025 Jan 29, 2026
Kynam Capital Management, LP History New 788,867 2,287 0.15% 5 +788,867 New Q4 2025 Feb 17, 2026
TWO SIGMA INVESTMENTS, LP History Added to 788,695 2,287 0.0% 0.0% 4 +636,462 418.08% Q4 2025 Feb 17, 2026
PRICE T ROWE ASSOCIATES INC /MD/ History Reduced 755,956 2,193 0.0% 0.0% 6 -120,382 -13.74% Q4 2025 Feb 17, 2026
ACADIAN ASSET MANAGEMENT LLC History Reduced 535,703 1,551 0.0% 0.0% 7 -4,862 -0.9% Q4 2025 Feb 10, 2026
MORGAN STANLEY History Added to 334,916 971 0.0% 0.0% 8 +50,713 17.84% Q4 2025 Feb 13, 2026
MARSHALL WACE, LLP History New 273,883 794 0.0% 9 +273,883 New Q4 2025 Feb 13, 2026
GEODE CAPITAL MANAGEMENT, LLC History Added to 272,886 791 0.0% 0.0% 10 +55,318 25.43% Q4 2025 Feb 09, 2026
RENAISSANCE TECHNOLOGIES LLC History Reduced 271,300 786 0.0% 0.0% 11 -272,700 -50.13% Q4 2025 Feb 12, 2026
BlackRock, Inc. History Added to 266,280 772 0.0% 0.0% 12 +1,307 0.49% Q4 2025 Feb 12, 2026
TWO SIGMA ADVISERS, LP History Added to 237,300 688 0.0% 0.0% 13 +14,600 6.56% Q4 2025 Feb 17, 2026
SUSQUEHANNA INTERNATIONAL GROUP, LLP History New 168,409 488 0.0% 14 +168,409 New Q4 2025 Feb 17, 2026
TD ASSET MANAGEMENT INC History No change 160,652 465 0.0% 0.0% 15 0 0.0% Q4 2025 Feb 10, 2026
MILLENNIUM MANAGEMENT LLC History Reduced 150,997 437 0.0% 0.0% 16 -996,047 -86.84% Q4 2025 Feb 17, 2026
STATE STREET CORP History Added to 127,292 369 0.0% 0.0% 17 +29,700 30.43% Q4 2025 Feb 13, 2026
SPHERA FUNDS MANAGEMENT LTD. History New 122,752 355 0.07% 18 +122,752 New Q4 2025 Feb 17, 2026
GOLDMAN SACHS GROUP INC History Added to 117,477 340 0.0% 0.0% 19 +38,150 48.09% Q4 2025 Mar 25, 2026
JANE STREET GROUP, LLC History Added to 111,040 322 0.0% 0.0% 20 +76,218 218.88% Q4 2025 Feb 12, 2026
OMERS ADMINISTRATION Corp History New 73,000 211 0.0% 21 +73,000 New Q4 2025 Feb 13, 2026
MANUFACTURERS LIFE INSURANCE COMPANY, THE History New 70,546 200 0.0% 22 +70,546 New Q4 2025 Feb 13, 2026
Point72 Asset Management, L.P. History New 59,168 171 0.0% 23 +59,168 New Q4 2025 Feb 17, 2026
BRIDGEWAY CAPITAL MANAGEMENT, LLC History No change 53,500 155 0.0% 0.0% 24 0 0.0% Q4 2025 Feb 17, 2026
Focus Partners Wealth History New 50,007 145 0.0% 26 +50,007 New Q4 2025 Feb 13, 2026
XTX Topco Ltd History Added to 50,159 145 0.0% 0.0% 27 +34,581 221.99% Q4 2025 Feb 17, 2026
NORTHERN TRUST CORP History Added to 50,120 145 0.0% 0.0% 25 +13,699 37.61% Q4 2025 Feb 17, 2026
Connor, Clark & Lunn Investment Management Ltd. History New 46,090 133 0.0% 28 +46,090 New Q4 2025 Feb 10, 2026
Cerity Partners LLC History Reduced 32,953 95 0.0% 0.0% 29 -1,380 -4.02% Q4 2025 Feb 11, 2026
Qube Research & Technologies Ltd History New 21,551 62 0.0% 30 +21,551 New Q4 2025 Feb 17, 2026
PRUDENTIAL FINANCIAL INC History Reduced 15,520 45 0.0% 0.0% 31 -10,320 -39.94% Q4 2025 Feb 13, 2026
HSBC HOLDINGS PLC History Reduced 13,652 39 0.0% 0.0% 32 -95 -0.69% Q4 2025 Mar 20, 2026
BANK OF AMERICA CORP /DE/ History Added to 9,808 28 0.0% 0.0% 33 +960 10.85% Q4 2025 Feb 17, 2026
BARCLAYS PLC History Reduced 8,602 24 0.0% 0.0% 34 -110 -1.26% Q4 2025 Feb 13, 2026
FMR LLC History Reduced 6,152 17 0.0% 0.0% 35 -2,947 -32.39% Q4 2025 Feb 17, 2026
SBI Securities Co., Ltd. History No change 2,741 7 0.0% 0.0% 36 0 0.0% Q4 2025 Feb 03, 2026
UBS Group AG History Reduced 1,857 5 0.0% 0.0% 39 -2,314 -55.48% Q4 2025 Jan 29, 2026
CALDWELL SUTTER CAPITAL, INC. History New 2,000 5 0.0% 37 +2,000 New Q4 2025 Jan 30, 2026
ROYAL BANK OF CANADA History New 1,742 5 0.0% 38 +1,742 New Q4 2025 Feb 17, 2026
NISA INVESTMENT ADVISORS, LLC History No change 1,634 4 0.0% 0.0% 40 0 0.0% Q4 2025 Jan 15, 2026
PNC FINANCIAL SERVICES GROUP, INC. History No change 1,171 3 0.0% 0.0% 41 0 0.0% Q4 2025 Feb 06, 2026
CWM, LLC History Reduced 692 2 0.0% 0.0% 42 -527 -43.23% Q4 2025 Jan 26, 2026
GROUP ONE TRADING LLC History No change 500 1 0.0% 43 0 0.0% Q4 2025 Feb 12, 2026
Shay Capital LLC History Closed out 0 0 0.01% -100,000 -100.0% Q3 2025 Nov 14, 2025
GSA CAPITAL PARTNERS LLP History Closed out 0 0 0.01% -75,161 -100.0% Q3 2025 Nov 07, 2025
HRT FINANCIAL LP History Closed out 0 0 0.0% -16,901 -100.0% Q3 2025 Nov 14, 2025
AQR CAPITAL MANAGEMENT LLC History Closed out 0 0 0.0% -10,500 -100.0% Q3 2025 Nov 14, 2025
Tower Research Capital LLC (TRC) History Closed out 0 0 0.0% -6,927 -100.0% Q3 2025 Nov 14, 2025
CITIGROUP INC History Reduced 1 0 0.0% -5,974 -99.98% Q4 2025 Feb 13, 2026
JPMORGAN CHASE & CO History Reduced 62 0 0.0% -3,817 -98.4% Q4 2025 Feb 11, 2026
SIMPLEX TRADING, LLC History Closed out 0 0 -153 -100.0% Q3 2025 Nov 12, 2025
EverSource Wealth Advisors, LLC History Closed out 0 0 -89 -100.0% Q3 2025 Nov 10, 2025
BNP PARIBAS FINANCIAL MARKETS History Added to 95 0 +43 82.69% Q4 2025 Feb 10, 2026
IFP Advisors, Inc History Reduced 1 0 -17 -94.44% Q4 2025 Feb 06, 2026
Arax Advisory Partners History Closed out 0 0 -15 -100.0% Q3 2025 Nov 14, 2025
Optiver Holding B.V. History No change 20 0 0 0.0% Q4 2025 Feb 17, 2026