Septerna, Inc. - SEPN
Detailed investor-level table based on 13F positions.
Early Q1 2026 data: only 7 institutional holders reported so far. The full shareholder list will grow as more funds file with the SEC.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | History | No change | 6,995,858 | 195,044 | 2.0% | 1.62% | 1 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| TRV GP V, LLC | History | No change | 6,215,591 | 173,290 | 40.38% | 33.07% | 2 | 0 | 0.0% | Q4 2025 | Feb 13, 2026 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | History | Reduced | 4,809,470 | 134,088 | 0.91% | 0.66% | 3 | -110,426 | -2.24% | Q4 2025 | Feb 17, 2026 |
| TRV GP VI, LLC | History | No change | 4,211,659 | 117,421 | 79.05% | 72.26% | 4 | 0 | 0.0% | Q4 2025 | Feb 13, 2026 |
| Samsara BioCapital, LLC | History | No change | 3,149,128 | 87,797 | 9.06% | 7.73% | 5 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| GOLDMAN SACHS GROUP INC | History | Added to | 2,715,129 | 75,697 | 0.01% | 0.0% | 6 | +1,260,409 | 86.64% | Q4 2025 | Mar 25, 2026 |
| Siren, L.L.C. | History | Reduced | 2,000,000 | 55,760 | 1.66% | 1.62% | 7 | -202,514 | -9.19% | Q4 2025 | Feb 13, 2026 |
| BlackRock, Inc. | History | Added to | 1,801,328 | 50,221 | 0.0% | 0.0% | 8 | +341,533 | 23.4% | Q4 2025 | Feb 12, 2026 |
| BVF INC/IL | History | Reduced | 1,720,782 | 47,975 | 1.61% | 3.06% | 9 | -2,295,008 | -57.15% | Q4 2025 | Feb 17, 2026 |
| VANGUARD GROUP INC | History | Reduced | 1,508,195 | 42,048 | 0.0% | 0.0% | 10 | -10,562 | -0.7% | Q4 2025 | Jan 29, 2026 |
| Avoro Capital Advisors LLC | History | No change | 1,337,500 | 37,289 | 0.37% | 0.33% | 11 | 0 | 0.0% | Q4 2025 | Mar 13, 2026 |
| ADAR1 Capital Management, LLC | History | Reduced | 1,157,611 | 32,274 | 2.37% | 2.08% | 12 | -18,880 | -1.6% | Q4 2025 | Feb 18, 2026 |
| First Light Asset Management, LLC | History | New | 620,811 | 17,308 | 1.32% | — | 13 | +620,811 | New | Q4 2025 | Feb 17, 2026 |
| VR Adviser, LLC | History | No change | 610,808 | 17,029 | 0.84% | 0.65% | 14 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | History | Added to | 572,734 | 15,971 | 0.0% | 0.0% | 15 | +27,033 | 4.95% | Q4 2025 | Feb 09, 2026 |
| Casdin Capital, LLC | History | No change | 553,268 | 15,425 | 0.96% | 0.87% | 16 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| PRIMECAP MANAGEMENT CO/CA/ | History | New | 546,100 | 15,225 | 0.01% | — | 17 | +546,100 | New | Q4 2025 | Feb 11, 2026 |
| STATE STREET CORP | History | Added to | 540,028 | 15,055 | 0.0% | 0.0% | 18 | +121,068 | 28.9% | Q4 2025 | Feb 13, 2026 |
| PERCEPTIVE ADVISORS LLC | History | Reduced | 433,160 | 12,076 | 0.22% | 0.29% | 19 | -108,290 | -20.0% | Q4 2025 | Feb 17, 2026 |
| Woodline Partners LP | History | Added to | 385,310 | 10,742 | 0.04% | 0.03% | 20 | +102,725 | 36.35% | Q4 2025 | Feb 17, 2026 |
| Soleus Capital Management, L.P. | History | Added to | 383,368 | 10,688 | 0.39% | 0.02% | 21 | +365,108 | 1999.5% | Q4 2025 | Feb 12, 2026 |
| Catalio Capital Management, LP | History | No change | 294,360 | 8,206 | 1.45% | 1.02% | 22 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| MARSHALL WACE, LLP | History | New | 226,901 | 6,326 | 0.01% | — | 23 | +226,901 | New | Q4 2025 | Feb 13, 2026 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | History | No change | 222,702 | 6,208 | 0.01% | 0.01% | 24 | 0 | 0.0% | Q4 2025 | Jan 28, 2026 |
| Kalehua Capital Management LLC | History | New | 194,544 | 5,423 | 5.36% | — | 25 | +194,544 | New | Q4 2025 | Feb 13, 2026 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | History | Added to | 187,241 | 5,220 | 0.0% | 0.0% | 26 | +337 | 0.18% | Q4 2025 | Feb 13, 2026 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | History | Reduced | 168,600 | 4,700 | 0.0% | 0.0% | 27 | -222,800 | -56.92% | Q4 2025 | Feb 17, 2026 |
| Invesco Ltd. | History | Reduced | 162,014 | 4,516 | 0.0% | 0.0% | 28 | -15,056 | -8.5% | Q4 2025 | Feb 19, 2026 |
| NORTHERN TRUST CORP | History | Reduced | 154,196 | 4,298 | 0.0% | 0.0% | 29 | -13,149 | -7.86% | Q4 2025 | Feb 17, 2026 |
| JANE STREET GROUP, LLC | History | Reduced | 124,270 | 3,464 | 0.0% | 0.0% | 30 | -228,130 | -64.74% | Q4 2025 | Feb 12, 2026 |
| MILLENNIUM MANAGEMENT LLC | History | Reduced | 107,463 | 2,996 | 0.0% | 0.0% | 31 | -276,737 | -72.03% | Q4 2025 | Feb 17, 2026 |
| MORGAN STANLEY | History | Added to | 103,985 | 2,899 | 0.0% | 0.0% | 32 | +49,527 | 90.95% | Q4 2025 | Feb 13, 2026 |
| TWO SIGMA INVESTMENTS, LP | History | Added to | 92,809 | 2,587 | 0.0% | 0.0% | 33 | +475 | 0.51% | Q4 2025 | Feb 17, 2026 |
| CITADEL ADVISORS LLC | History | Added to | 87,845 | 2,449 | 0.0% | 0.0% | 34 | +62,845 | 251.38% | Q4 2025 | Feb 17, 2026 |
| FEDERATED HERMES, INC. | History | New | 78,905 | 2,199 | 0.0% | — | 35 | +78,905 | New | Q4 2025 | Feb 12, 2026 |
| HighVista Strategies LLC | History | New | 78,682 | 2,193 | 0.56% | — | 36 | +78,682 | New | Q4 2025 | Feb 17, 2026 |
| UBS Group AG | History | Added to | 68,817 | 1,918 | 0.0% | 0.0% | 37 | +9,771 | 16.55% | Q4 2025 | Jan 29, 2026 |
| JPMORGAN CHASE & CO | History | Added to | 68,338 | 1,905 | 0.0% | 0.0% | 38 | +59,602 | 682.26% | Q4 2025 | Feb 11, 2026 |
| Rangeley Capital, LLC | History | Reduced | 65,800 | 1,834 | 1.52% | 1.43% | 39 | -22,200 | -25.23% | Q4 2025 | Feb 17, 2026 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | History | New | 61,370 | 1,710 | 0.01% | — | 40 | +61,370 | New | Q4 2025 | Feb 13, 2026 |
| Bank of New York Mellon Corp | History | Added to | 55,332 | 1,542 | 0.0% | 0.0% | 41 | +3,701 | 7.17% | Q4 2025 | Feb 10, 2026 |
| AMERICAN CENTURY COMPANIES INC | History | Added to | 50,689 | 1,413 | 0.0% | 0.0% | 42 | +25,406 | 100.49% | Q4 2025 | Feb 13, 2026 |
| Longaeva Partners L.P. | History | Reduced | 49,902 | 1,391 | 0.12% | 0.15% | 43 | -7,162 | -12.55% | Q4 2025 | Feb 17, 2026 |
| Numerai GP LLC | History | New | 45,866 | 1,278 | 0.15% | — | 44 | +45,866 | New | Q4 2025 | Feb 17, 2026 |
| Trexquant Investment LP | History | New | 44,005 | 1,226 | 0.01% | — | 45 | +44,005 | New | Q4 2025 | Feb 17, 2026 |
| BARCLAYS PLC | History | Added to | 38,147 | 1,063 | 0.0% | 0.0% | 46 | +8,045 | 26.73% | Q4 2025 | Feb 13, 2026 |
| ExodusPoint Capital Management, LP | History | New | 37,867 | 1,055 | 0.01% | — | 47 | +37,867 | New | Q4 2025 | Feb 17, 2026 |
| BANK OF AMERICA CORP /DE/ | History | Reduced | 37,594 | 1,048 | 0.0% | 0.0% | 48 | -13,901 | -26.99% | Q4 2025 | Feb 17, 2026 |
| Alyeska Investment Group, L.P. | History | No change | 35,000 | 975 | 0.0% | 0.0% | 49 | 0 | 0.0% | Q4 2025 | Feb 13, 2026 |
| ALGERT GLOBAL LLC | History | New | 34,944 | 974 | 0.02% | — | 50 | +34,944 | New | Q4 2025 | Feb 17, 2026 |
| ACADIAN ASSET MANAGEMENT LLC | History | New | 30,877 | 858 | 0.0% | — | 51 | +30,877 | New | Q4 2025 | Feb 10, 2026 |
| WELLS FARGO & COMPANY/MN | History | Added to | 26,529 | 739 | 0.0% | 0.0% | 52 | +6,382 | 31.68% | Q4 2025 | Feb 13, 2026 |
| RHUMBLINE ADVISERS | History | Reduced | 26,419 | 736 | 0.0% | 0.0% | 53 | -1,185 | -4.29% | Q4 2025 | Feb 13, 2026 |
| Nuveen, LLC | History | Added to | 25,798 | 719 | 0.0% | 0.0% | 54 | +1,837 | 7.67% | Q4 2025 | Feb 12, 2026 |
| TWO SIGMA ADVISERS, LP | History | Added to | 25,700 | 716 | 0.0% | 0.0% | 55 | +5,000 | 24.15% | Q4 2025 | Feb 17, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | History | Reduced | 25,443 | 710 | 0.0% | 0.0% | 56 | -1,981 | -7.22% | Q4 2025 | Feb 17, 2026 |
| Logos Global Management LP | History | Reduced | 23,548 | 656 | 0.04% | 0.14% | 57 | -60,000 | -71.82% | Q4 2025 | Feb 17, 2026 |
| XTX Topco Ltd | History | New | 23,315 | 650 | 0.02% | — | 58 | +23,315 | New | Q4 2025 | Feb 17, 2026 |
| VARCOV Co. | History | New | 22,634 | 631 | 0.25% | — | 59 | +22,634 | New | Q4 2025 | Feb 17, 2026 |
| ALLIANCEBERNSTEIN L.P. | History | Reduced | 19,600 | 546 | 0.0% | 0.0% | 60 | -2,500 | -11.31% | Q4 2025 | Feb 17, 2026 |
| TUDOR INVESTMENT CORP ET AL | History | New | 18,053 | 503 | 0.0% | — | 61 | +18,053 | New | Q4 2025 | Feb 17, 2026 |
| FRANKLIN RESOURCES INC | History | New | 16,852 | 469 | 0.0% | — | 62 | +16,852 | New | Q4 2025 | Feb 11, 2026 |
| Russell Investments Group, Ltd. | History | Added to | 15,310 | 426 | 0.0% | 0.0% | 63 | +13,414 | 707.49% | Q4 2025 | Feb 17, 2026 |
| DEUTSCHE BANK AG\ | History | Added to | 14,879 | 414 | 0.0% | 0.0% | 64 | +744 | 5.26% | Q4 2025 | Feb 11, 2026 |
| Squarepoint Ops LLC | History | New | 14,847 | 413 | 0.0% | — | 65 | +14,847 | New | Q4 2025 | Feb 13, 2026 |
| STRS OHIO | History | New | 14,600 | 407 | 0.0% | — | 66 | +14,600 | New | Q4 2025 | Feb 02, 2026 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | History | New | 18,550 | 398 | 0.0% | — | 67 | +18,550 | New | Q4 2025 | Feb 11, 2026 |
| AMERIPRISE FINANCIAL INC | History | New | 14,090 | 392 | 0.0% | — | 68 | +14,090 | New | Q4 2025 | Feb 17, 2026 |
| MetLife Investment Management, LLC | History | No change | 13,685 | 381 | 0.0% | 0.0% | 69 | 0 | 0.0% | Q4 2025 | Feb 12, 2026 |
| INTECH INVESTMENT MANAGEMENT LLC | History | New | 13,283 | 370 | 0.0% | — | 70 | +13,283 | New | Q4 2025 | Feb 10, 2026 |
| OSAIC HOLDINGS, INC. | History | Reduced | 12,693 | 353 | 0.0% | 0.0% | 71 | -170 | -1.32% | Q4 2025 | Feb 17, 2026 |
| Seven Fleet Capital Management LP | History | New | 11,445 | 319 | 0.22% | — | 72 | +11,445 | New | Q4 2025 | Apr 02, 2026 |
| Dynamic Technology Lab Private Ltd | History | New | 10,810 | 301 | 0.07% | — | 73 | +10,810 | New | Q4 2025 | Feb 13, 2026 |
| PharVision Advisers, LLC | History | Reduced | 10,739 | 299 | 0.15% | 0.13% | 74 | -1,193 | -10.0% | Q4 2025 | Feb 17, 2026 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | History | New | 10,594 | 295 | 0.0% | — | 75 | +10,594 | New | Q4 2025 | Feb 17, 2026 |
| Virtus Investment Advisers, LLC | History | New | 10,457 | 291 | 0.08% | — | 76 | +10,457 | New | Q4 2025 | Feb 17, 2026 |
| China Universal Asset Management Co., Ltd. | History | New | 10,296 | 287 | 0.02% | — | 77 | +10,296 | New | Q4 2025 | Jan 29, 2026 |
| Baader Bank Aktiengesellschaft | History | New | 10,000 | 278 | 0.02% | — | 78 | +10,000 | New | Q4 2025 | Feb 05, 2026 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | History | Added to | 9,934 | 276 | 0.0% | 0.0% | 79 | +143 | 1.46% | Q4 2025 | Feb 17, 2026 |
| Atom Investors LP | History | New | 9,791 | 272 | 0.02% | — | 80 | +9,791 | New | Q4 2025 | Feb 17, 2026 |
| CITIGROUP INC | History | Added to | 9,561 | 266 | 0.0% | 0.0% | 81 | +9,312 | 3739.76% | Q4 2025 | Feb 13, 2026 |
| Graham Capital Management, L.P. | History | New | 8,971 | 250 | 0.01% | — | 82 | +8,971 | New | Q4 2025 | Feb 17, 2026 |
| Jump Financial, LLC | History | New | 8,399 | 234 | 0.0% | — | 83 | +8,399 | New | Q4 2025 | Feb 17, 2026 |
| BANK OF NOVA SCOTIA | History | New | 8,300 | 231 | 0.0% | — | 84 | +8,300 | New | Q4 2025 | Feb 13, 2026 |
| AQR CAPITAL MANAGEMENT LLC | History | New | 7,826 | 218 | 0.0% | — | 85 | +7,826 | New | Q4 2025 | Feb 17, 2026 |
| Caitong International Asset Management Co., Ltd | History | New | 6,340 | 176 | 0.04% | — | 86 | +6,340 | New | Q4 2025 | Mar 03, 2026 |
| NEW YORK STATE COMMON RETIREMENT FUND | History | Added to | 5,600 | 156 | 0.0% | 0.0% | 87 | +2,700 | 93.1% | Q4 2025 | Feb 12, 2026 |
| BNP PARIBAS FINANCIAL MARKETS | History | Added to | 5,449 | 151 | 0.0% | 0.0% | 88 | +1,294 | 31.14% | Q4 2025 | Feb 10, 2026 |
| Police & Firemen's Retirement System of New Jersey | History | No change | 5,175 | 144 | 0.0% | 0.0% | 89 | 0 | 0.0% | Q4 2025 | Feb 13, 2026 |
| BALYASNY ASSET MANAGEMENT L.P. | History | New | 3,571 | 99 | 0.0% | — | 90 | +3,571 | New | Q4 2025 | Feb 17, 2026 |
| FMR LLC | History | Reduced | 3,307 | 92 | 0.0% | 0.0% | 91 | -131 | -3.81% | Q4 2025 | Feb 17, 2026 |
| Mirae Asset Global Investments Co., Ltd. | History | New | 2,176 | 60 | 0.0% | — | 93 | +2,176 | New | Q4 2025 | Jan 26, 2026 |
| Tower Research Capital LLC (TRC) | History | Added to | 2,156 | 60 | 0.0% | 0.0% | 92 | +1,197 | 124.82% | Q4 2025 | Feb 17, 2026 |
| Covestor Ltd | History | Reduced | 1,941 | 54 | 0.03% | 0.04% | 96 | -1,679 | -46.38% | Q4 2025 | Feb 06, 2026 |
| Legal & General Group Plc | History | No change | 1,945 | 54 | 0.0% | 0.0% | 94 | 0 | 0.0% | Q4 2025 | Feb 09, 2026 |
| Ameritas Investment Partners, Inc. | History | No change | 1,944 | 54 | 0.0% | 0.0% | 95 | 0 | 0.0% | Q4 2025 | Feb 11, 2026 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | History | Reduced | 1,316 | 36 | 0.0% | 0.0% | 97 | -55 | -4.01% | Q4 2025 | Feb 17, 2026 |
| Global Retirement Partners, LLC | History | New | 1,256 | 35 | 0.0% | — | 98 | +1,256 | New | Q4 2025 | Feb 06, 2026 |
| Sterling Capital Management LLC | History | Reduced | 1,232 | 34 | 0.0% | 0.0% | 99 | -243 | -16.47% | Q4 2025 | Feb 13, 2026 |
| SIGNATUREFD, LLC | History | Added to | 989 | 27 | 0.0% | 0.0% | 100 | +23 | 2.38% | Q4 2025 | Jan 20, 2026 |
| GROUP ONE TRADING LLC | History | Reduced | 944 | 26 | 0.0% | 0.0% | 101 | -10,445 | -91.71% | Q4 2025 | Feb 12, 2026 |
| GAMMA Investing LLC | History | Added to | 916 | 25 | 0.0% | 0.0% | 103 | +112 | 13.93% | Q4 2025 | Jan 05, 2026 |
| CWM, LLC | History | Added to | 888 | 25 | 0.0% | 0.0% | 102 | +4 | 0.45% | Q4 2025 | Jan 26, 2026 |
| GF FUND MANAGEMENT CO. LTD. | History | New | 878 | 24 | 0.0% | — | 104 | +878 | New | Q4 2025 | Jan 27, 2026 |
| Quarry LP | History | Reduced | 724 | 20 | 0.0% | 0.01% | 105 | -1,012 | -58.29% | Q4 2025 | Feb 13, 2026 |
| AMALGAMATED BANK | History | Added to | 672 | 19 | 0.0% | 0.0% | 106 | +38 | 5.99% | Q4 2025 | Feb 05, 2026 |
| ROYAL BANK OF CANADA | History | New | 628 | 18 | 0.0% | — | 107 | +628 | New | Q4 2025 | Feb 17, 2026 |
| NISA INVESTMENT ADVISORS, LLC | History | Added to | 341 | 9 | 0.0% | 0.0% | 108 | +198 | 138.46% | Q4 2025 | Jan 15, 2026 |
| Pinnacle Wealth Planning Services, Inc. | History | New | 322 | 8 | 0.0% | — | 109 | +322 | New | Q4 2025 | Feb 13, 2026 |
| Versant Capital Management, Inc | History | No change | 261 | 7 | 0.0% | 0.0% | 110 | 0 | 0.0% | Q4 2025 | Jan 08, 2026 |
| N.E.W. Advisory Services LLC | History | New | 180 | 5 | 0.0% | — | 113 | +180 | New | Q4 2025 | Jan 28, 2026 |
| US BANCORP \DE\ | History | Reduced | 190 | 5 | 0.0% | 0.0% | 111 | -75 | -28.3% | Q4 2025 | Jan 30, 2026 |
| PNC FINANCIAL SERVICES GROUP, INC. | History | No change | 198 | 5 | 0.0% | 0.0% | 112 | 0 | 0.0% | Q4 2025 | Feb 06, 2026 |
| Daiwa Securities Group Inc. | History | New | 149 | 4 | 0.0% | — | 114 | +149 | New | Q4 2025 | Feb 11, 2026 |
| MassMutual Private Wealth & Trust, FSB | History | New | 63 | 1 | 0.0% | — | 115 | +63 | New | Q4 2025 | Jan 07, 2026 |
| Cornerstone Financial Management LLC | History | New | 52 | 1 | 0.0% | — | 119 | +52 | New | Q4 2025 | Feb 13, 2026 |
| SBI Securities Co., Ltd. | History | Added to | 55 | 1 | 0.0% | — | 117 | +5 | 10.0% | Q4 2025 | Feb 03, 2026 |
| EverSource Wealth Advisors, LLC | History | No change | 63 | 1 | 0.0% | 0.0% | 116 | 0 | 0.0% | Q4 2025 | Feb 06, 2026 |
| Fortitude Family Office, LLC | History | No change | 71 | 1 | 0.0% | 0.0% | 118 | 0 | 0.0% | Q4 2025 | Jan 15, 2026 |
| Checkpoint Capital L.P. | History | Closed out | 0 | 0 | — | 1.78% | — | -283,158 | -100.0% | Q3 2025 | Nov 14, 2025 |
| Sio Capital Management, LLC | History | Closed out | 0 | 0 | — | 0.9% | — | -189,199 | -100.0% | Q3 2025 | Nov 13, 2025 |
| Walleye Capital LLC | History | Closed out | 0 | 0 | — | 0.01% | — | -80,341 | -100.0% | Q3 2025 | Nov 14, 2025 |
| SIMPLEX TRADING, LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -53,100 | -100.0% | Q3 2025 | Nov 12, 2025 |
| Verition Fund Management LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -20,131 | -100.0% | Q3 2025 | Nov 14, 2025 |
| Arax Advisory Partners | History | Reduced | 3 | 0 | — | 0.0% | — | -60 | -95.24% | Q4 2025 | Feb 13, 2026 |
| Aster Capital Management (DIFC) Ltd | History | New | 20 | 0 | — | — | — | +20 | New | Q4 2025 | Feb 17, 2026 |
| NATIONAL BANK OF CANADA /FI/ | History | Closed out | 0 | 0 | — | — | — | -8 | -100.0% | Q3 2025 | Nov 14, 2025 |
| Farther Finance Advisors, LLC | History | New | 1 | 0 | — | — | — | +1 | New | Q4 2025 | Jan 23, 2026 |
| ROTHSCHILD INVESTMENT LLC | History | No change | 30 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Feb 10, 2026 |