Spero Therapeutics, Inc. - SPRO
Detailed investor-level table based on 13F positions.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GSK plc | History | No change | 9,190,606 | 20,311 | 3.37% | 3.37% | 1 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| PFIZER INC | History | No change | 2,362,348 | 5,338 | 3.13% | 3.13% | 2 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | History | No change | 2,036,226 | 4,500 | 0.0% | 0.0% | 3 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| MACKENZIE FINANCIAL CORP | History | New | 1,831,254 | 2,215 | 0.0% | — | 4 | +1,831,254 | New | Q3 2026 | Nov 02, 2026 |
| RENAISSANCE TECHNOLOGIES LLC | History | No change | 947,904 | 2,094 | 0.0% | 0.0% | 5 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Alphabet Inc. | History | No change | 889,979 | 1,966 | 0.0% | 0.0% | 6 | 0 | 0.0% | Q2 2026 | Aug 06, 2026 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | History | No change | 807,590 | 1,784 | 0.0% | 0.0% | 7 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| BlackRock, Inc. | History | No change | 594,404 | 1,313 | 0.0% | 0.0% | 8 | 0 | 0.0% | Q2 2026 | Aug 07, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | History | No change | 566,329 | 1,252 | 0.0% | 0.0% | 9 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| RAYMOND JAMES FINANCIAL INC | History | No change | 521,705 | 1,152 | 0.0% | 0.0% | 10 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| TWO SIGMA INVESTMENTS, LP | History | No change | 382,814 | 846 | 0.0% | 0.0% | 11 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | History | No change | 332,970 | 735 | 0.0% | 0.0% | 12 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| VANGUARD FIDUCIARY TRUST CO | History | No change | 287,648 | 635 | 0.0% | 0.0% | 13 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| GSA CAPITAL PARTNERS LLP | History | No change | 285,906 | 632 | 0.04% | 0.04% | 14 | 0 | 0.0% | Q2 2026 | Aug 06, 2026 |
| GOLDMAN SACHS GROUP INC | History | No change | 256,985 | 567 | 0.0% | 0.0% | 15 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| JANE STREET GROUP, LLC | History | No change | 231,997 | 512 | 0.0% | 0.0% | 16 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| STATE STREET CORP | History | No change | 214,751 | 474 | 0.0% | 0.0% | 17 | 0 | 0.0% | Q2 2026 | Sep 22, 2026 |
| UBS Group AG | History | No change | 139,680 | 308 | 0.0% | 0.0% | 18 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | History | No change | 114,800 | 253 | 0.0% | 0.0% | 19 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| NORTHERN TRUST CORP | History | No change | 108,274 | 239 | 0.0% | 0.0% | 20 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Point72 Asset Management, L.P. | History | No change | 104,377 | 230 | 0.0% | 0.0% | 21 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Ionic Capital Management LLC | History | No change | 102,698 | 226 | 0.03% | 0.03% | 22 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Federation des caisses Desjardins du Quebec | History | No change | 91,900 | 202 | 0.0% | 0.0% | 23 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Shay Capital LLC | History | No change | 72,391 | 159 | 0.01% | 0.01% | 24 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| CITADEL ADVISORS LLC | History | No change | 65,600 | 144 | 0.0% | 0.0% | 25 | 0 | 0.0% | Q2 2026 | Sep 02, 2026 |
| Invesco Ltd. | History | No change | 64,245 | 141 | 0.0% | 0.0% | 26 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Verdad Advisers, LP | History | No change | 51,335 | 113 | 0.11% | 0.11% | 27 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| XTX Topco Ltd | History | No change | 50,536 | 111 | 0.0% | 0.0% | 28 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| DIMENSIONAL FUND ADVISORS LP | History | Reduced | 91,287 | 110 | 0.0% | 0.0% | 29 | -183,533 | -66.78% | Q3 2026 | Nov 04, 2026 |
| AMERICAN CENTURY COMPANIES INC | History | No change | 36,811 | 81 | 0.0% | 0.0% | 30 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | History | No change | 28,565 | 63 | 0.0% | 0.0% | 31 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Vanguard Global Advisers, LLC | History | No change | 25,446 | 56 | 0.0% | 0.0% | 32 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Global Retirement Partners, LLC | History | No change | 25,000 | 55 | 0.0% | 0.0% | 33 | 0 | 0.0% | Q2 2026 | Aug 06, 2026 |
| StoneX Group Inc. | History | New | 38,241 | 45 | 0.0% | — | 34 | +38,241 | New | Q3 2026 | Nov 03, 2026 |
| SIMPLEX TRADING, LLC | History | Reduced | 36,830 | 44 | 0.0% | 0.0% | 35 | -24,482 | -39.93% | Q3 2026 | Nov 04, 2026 |
| MILLENNIUM MANAGEMENT LLC | History | No change | 19,298 | 42 | 0.0% | 0.0% | 36 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Susquehanna Portfolio Strategies, LLC | History | No change | 17,628 | 38 | 0.0% | 0.0% | 37 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Capital Asset Advisory Services LLC | History | No change | 32,548 | 36 | 0.0% | 0.0% | 38 | 0 | 0.0% | Q3 2026 | Oct 30, 2026 |
| Three Seasons Wealth, LLC | History | No change | 30,000 | 36 | 0.0% | 0.01% | 39 | 0 | 0.0% | Q3 2026 | Nov 03, 2026 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | History | No change | 16,095 | 35 | 0.0% | 0.0% | 40 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| OPPENHEIMER & CO INC | History | Added to | 26,750 | 32 | 0.0% | 0.0% | 41 | +3,900 | 17.07% | Q3 2026 | Oct 26, 2026 |
| Qube Research & Technologies Ltd | History | No change | 13,644 | 30 | 0.0% | 0.0% | 42 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| FNY Investment Advisers, LLC | History | Added to | 21,300 | 25 | 0.01% | 0.01% | 44 | +13,000 | 156.63% | Q3 2026 | Oct 16, 2026 |
| SG Americas Securities, LLC | History | No change | 11,268 | 25 | 0.0% | 0.0% | 43 | 0 | 0.0% | Q2 2026 | Aug 07, 2026 |
| GROUP ONE TRADING LLC | History | No change | 10,869 | 24 | 0.0% | 0.0% | 45 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| TWO SIGMA SECURITIES, LLC | History | No change | 10,576 | 23 | 0.0% | 0.0% | 46 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| PRUDENTIAL FINANCIAL INC | History | No change | 10,400 | 22 | 0.0% | 0.0% | 47 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| Assenagon Asset Management S.A. | History | Reduced | 17,762 | 21 | 0.0% | 0.0% | 48 | -874 | -4.69% | Q3 2026 | Oct 15, 2026 |
| JONES FINANCIAL COMPANIES LLLP | History | No change | 7,678 | 17 | 0.0% | 0.0% | 49 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Torrey Growth & Income Advisors | History | New | 11,025 | 13 | 0.0% | — | 50 | +11,025 | New | Q3 2026 | Nov 04, 2026 |
| ROYAL BANK OF CANADA | History | No change | 2,014 | 4 | 0.0% | 0.0% | 51 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| MORGAN STANLEY | History | No change | 914 | 2 | 0.0% | 0.0% | 52 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| AXXCESS WEALTH MANAGEMENT, LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -32,548 | -100.0% | Q3 2026 | Oct 21, 2026 |
| DLK Investment Management, LLC | History | Closed out | 0 | 0 | — | 0.02% | — | -31,355 | -100.0% | Q3 2026 | Oct 08, 2026 |
| CITIGROUP INC | History | Closed out | 0 | 0 | — | 0.0% | — | -9,625 | -100.0% | Q3 2026 | Nov 04, 2026 |
| SBI Securities Co., Ltd. | History | Added to | 61 | 0 | — | — | — | +48 | 369.23% | Q3 2026 | Oct 21, 2026 |
| JPMORGAN CHASE & CO | History | No change | 236 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| US BANCORP \DE\ | History | No change | 151 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| WELLS FARGO & COMPANY/MN | History | No change | 200 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| FMR LLC | History | No change | 300 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| OSAIC HOLDINGS, INC. | History | No change | 290 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Farther Finance Advisors, LLC | History | No change | 10 | 0 | — | — | — | 0 | 0.0% | Q3 2026 | Oct 08, 2026 |
| Rialto Wealth Management, LLC | History | No change | 172 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 11, 2026 |