Rock Springs Capital Management LP

Q4 2025 13F-HR Holdings

Location
Baltimore, MD
Holdings as of
12/31/2025
Date filed
2/17/2026
Form type
13F-HR
Num holdings
99
Total value ($000)
$1,950,204
Net value change ($000)
+238,680 (13.9%)
New positions
18
Sold out positions
12
Turnover %
9.1%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
RVMD 43,997 70.6%
LLY 32,851 40.8%
TVTX 32,718 63.2%
EXAS 28,649 88.2%
GPCR 25,408 95.4%
CDTX 21,373 89.5%
MDGL 18,126 28.7%
COGT 15,679 108.3%
UNH 13,468 NEW
KYMR 13,171 51.7%
Top Reduces (Value $000, Stocks/ETFs)
Merus N.V. -56,212 -100.0%
AKRO -29,747 -100.0%
ARGX -18,459 -17.5%
AGIO -16,723 -43.5%
EVH -14,257 -57.1%
ZLAB -12,498 -46.6%
MREO -9,416 -100.0%
OMDA -8,663 -42.6%
RARE -8,343 -22.3%
LENZ -6,884 -62.6%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 1,109 (0.1% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
Filter:
Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type