Opaleye Management Inc.

Q3 2025 13F-HR Holdings

Location
Boston, MA
Holdings as of
9/30/2025
Date filed
11/14/2025
Form type
13F-HR
Num holdings
43
Total value ($000)
$707,321
Net value change ($000)
+213,180 (43.1%)
New positions
11
Sold out positions
8
Turnover %
13.0%
Sector allocation + QoQ delta (equities-only)
Prev filing: 8/15/2025 Next filing: 4/13/2026 SEC filing

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
HROW 68,884 57.8%
LQDA 28,626 92.8%
ETON 21,393 52.5%
RYTM 16,612 55.3%
APGE 14,432 NEW
ALKERMES PLC 13,500 NEW
STOK 9,647 151.2%
CGON 9,599 138.8%
ANNX 7,930 NEW
DERM 6,232 913.8%
Top Reduces (Value $000, Stocks/ETFs)
Vigil Neuroscience, Inc. -7,950 -100.0%
ANIK -6,229 -100.0%
DNA -5,625 -100.0%
ARVN -3,949 -31.9%
EPIX -3,757 -100.0%
CRGX -2,746 -100.0%
TARA -2,591 -100.0%
RCEL -2,061 -100.0%
ZNTL -1,754 -78.6%
LRMR -1,313 -11.1%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type