RTW INVESTMENTS, LP

Q1 2026 13F-HR Holdings

Location
New York, NY
Holdings as of
3/31/2026
Date filed
5/15/2026
Form type
13F-HR
Num holdings
88
Total value ($000)
$10,049,753
Net value change ($000)
+66,436 (0.7%)
New positions
9
Sold out positions
12
Turnover %
8.9%
Sector allocation + QoQ delta (equities-only)
Prev filing: 2/17/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q4 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
CGON 389,188 465.8%
CELC 292,069 532.3%
TNGX 265,037 2006.0%
ERAS 260,877 47779.7%
PTGX 91,366 20.7%
SYRE 73,760 54.0%
HNGE 58,001 353.2%
ISRG 44,087 76.9%
WAY 39,299 NEW
ORKA 38,570 61.8%
Top Reduces (Value $000, Stocks/ETFs)
PEN -269,403 -100.0%
AXSM -162,185 -100.0%
MDGL -117,369 -10.1%
NTRA -93,647 -27.3%
PODD -92,264 -100.0%
MASI -88,869 -100.0%
PTCT -60,655 -10.3%
COGT -59,572 -22.1%
BBNX -56,135 -73.7%
RAPT -55,451 -100.0%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type