Spyre Therapeutics, Inc. - SYRE
Sector:
Healthcare
· Industry:
Pharmaceutical Preparations
Website:
No information yet
· Social:
No information yet
Company profile
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Quarter snapshot
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Q4 2025
· Q3 2025
Value (USD)
Total reported value ($000)
$2.96B
QoQ value delta ($000)
+$1.959B
(+195.54%)
Implied price effect (QoQ)
+116.84%
Shares
Total shares
81,459,284
QoQ shares delta
+21,692,255
(+36.29%)
Total shares held by funds (by quarter)
Market chart (SYRE)
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Top holders (Q4 2025)
Top 25 only
Full list
| Manager | Value ($000) | Shares | % of 13F |
|---|---|---|---|
| FMR LLC | 381,287 | 11,638,819 | 0.02% |
| CAXTON CORP | 292,194 | 8,919 | 6.83% |
| BlackRock, Inc. | 180,904 | 5,522,101 | 0.0% |
| RTW INVESTMENTS, LP | 136,674 | 4,171,996 | 1.37% |
| VANGUARD GROUP INC | 132,189 | 4,035,074 | 0.0% |
| Fairmount Funds Management LLC | 131,632 | 4,018,101 | 10.02% |
| VR Adviser, LLC | 120,735 | 3,685,448 | 5.96% |
| Capital International Investors | 114,415 | 3,492,541 | 0.02% |
| PERCEPTIVE ADVISORS LLC | 100,547 | 3,069,225 | 1.79% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 94,428 | 2,882,420 | 0.64% |
| Commodore Capital LP | 78,238 | 2,388,245 | 5.21% |
| STATE STREET CORP | 74,130 | 2,262,839 | 0.0% |
| TCG Crossover Management, LLC | 62,263 | 1,900,582 | 2.06% |
| TANG CAPITAL MANAGEMENT LLC | 61,988 | 1,892,200 | 3.06% |
| JANUS HENDERSON GROUP PLC | 59,918 | 1,829,009 | 0.03% |
| GEODE CAPITAL MANAGEMENT, LLC | 54,362 | 1,659,140 | 0.0% |
| BRAIDWELL LP | 53,549 | 1,634,615 | 1.71% |
| RA CAPITAL MANAGEMENT, L.P. | 53,124 | 1,621,620 | 0.54% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 52,479 | 1,601,882 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | 50,754 | 1,549,284 | 0.01% |
| Paradigm Biocapital Advisors LP | 48,067 | 1,467,266 | 1.23% |
| Remedium Capital Partners, LLC | 47,706 | 1,456,231 | 28.03% |
| Affinity Asset Advisors, LLC | 46,931 | 1,432,591 | 2.67% |
| FRANKLIN RESOURCES INC | 36,339 | 1,109,274 | 0.01% |
| BAKER BROS. ADVISORS LP | 32,760 | 1,000,000 | 0.19% |