Spyre Therapeutics, Inc. - SYRE

Sector: Healthcare · Industry: Pharmaceutical Preparations
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Company profile

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Quarter snapshot

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Q2 2026 · Q1 2026
Value (USD)
Total reported value ($000)
$8.661B
QoQ value delta ($000)
+$4.479B (+107.1%)
Implied price effect (QoQ)
+75.19%
Shares
Total shares
98,152,793
QoQ shares delta
+15,120,614 (+18.21%)
Total shares held by funds (by quarter)
Shares (left)

Fund holders include prior positions carried forward until a new 13F confirms a change. Reported holders have reported a position in this security for that quarter; this is not the total number of 13F filers.

Market chart (SYRE)

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Top holders (Q2 2026)

Top 25 only Full list
Partial Q2 2026 data: 268 holders have filed so far. Prior holders are carried forward until their next 13F confirms a change.
Manager Value ($000) Shares % of 13F
FMR LLC 1,156,464 13,026,187 0.05%
BlackRock, Inc. 577,656 6,506,605 0.01%
PERCEPTIVE ADVISORS LLC 383,484 4,319,496 5.76%
RTW INVESTMENTS, LP 377,492 4,251,996 3.22%
Paradigm Biocapital Advisors LP 340,984 3,840,778 6.38%
VANGUARD CAPITAL MANAGEMENT LLC 306,173 3,448,681 0.01%
STATE STREET CORP 271,437 3,057,416 0.01%
Venrock Adviser, LLC 265,048 2,985,448 8.04%
PRICE T ROWE ASSOCIATES INC /MD/ 262,866 2,960,855 0.03%
DRIEHAUS CAPITAL MANAGEMENT LLC 248,509 2,799,166 1.44%
GEODE CAPITAL MANAGEMENT, LLC 239,258 2,562,265 0.01%
VANGUARD PORTFOLIO MANAGEMENT LLC 206,866 2,330,098 0.01%
Capital World Investors 205,574 2,315,553 0.02%
Jupiter Topco LLC 195,881 2,206,936 0.08%
TCG Crossover Management, LLC 168,733 1,900,582 4.06%
TANG CAPITAL MANAGEMENT LLC 167,989 1,892,200 7.63%
BANK OF AMERICA CORP /DE/ 157,837 1,777,854 0.01%
ADAGE CAPITAL PARTNERS GP, L.L.C. 152,905 1,722,300 0.21%
WELLINGTON MANAGEMENT GROUP LLP 140,406 1,581,505 0.02%
GOLDMAN SACHS GROUP INC 131,222 1,478,059 0.01%
FRANKLIN RESOURCES INC 130,767 1,472,943 0.03%
Remedium Capital Partners, LLC 129,988 1,464,169 28.78%
Affinity Asset Advisors, LLC 113,561 1,279,134 5.13%
JPMORGAN CHASE & CO 98,870 1,093,026 0.01%
Holocene Advisors, LP 90,126 1,015,170 0.2%