Commodore Capital LP

Q4 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
12/31/2025
Date filed
2/17/2026
Form type
13F-HR
Num holdings
33
Total value ($000)
$1,502,245
Net value change ($000)
-546,191 (-26.7%)
New positions
6
Sold out positions
10
Turnover %
46.5%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
RLAY 55,080 62.1%
SYRE 44,919 134.8%
TYRA 41,513 87.9%
ANRO 32,453 NEW
PALI 26,896 NEW
ORKA 19,424 57.6%
TERN 16,783 39.2%
KYMR 15,908 37.5%
REPL 13,851 NEW
AMLX 12,866 23.2%
Top Reduces (Value $000, Stocks/ETFs)
Merus N.V. -331,879 -100.0%
AGIO -93,859 -100.0%
VRDN -69,056 -100.0%
NUVL -65,747 -54.3%
CDTX -56,020 -100.0%
CNTA -44,103 -63.8%
SLNO -35,700 -39.1%
DRUG -28,859 -95.2%
PTGX -28,788 -42.3%
XENE -27,729 -25.6%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type