Paradigm Biocapital Advisors LP

Q4 2024 13F-HR Holdings

Location
New York, NY
Holdings as of
12/31/2024
Date filed
2/14/2025
Form type
13F-HR
Num holdings
28
Total value ($000)
$2,874,092
Net value change ($000)
-81,835 (-2.8%)
New positions
4
Sold out positions
7
Turnover %
11.9%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2024 Next filing: 5/15/2025 SEC filing

Snapshot: Change Analysis

Compared to Q3 2024
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
JANX 79,188 72.6%
ONC 68,809 153.0%
TARS 59,925 74.7%
MLTX 49,000 104.3%
RVMD 45,639 18.9%
EWTX 45,545 61.2%
PCVX 44,738 62.4%
ARGX 35,602 13.7%
TECX 22,397 NEW
LENZ 22,243 NEW
Top Reduces (Value $000, Stocks/ETFs)
NUVL -91,655 -17.9%
KURA -84,634 -100.0%
ARVN -57,633 -100.0%
Merus N.V. -51,587 -42.1%
CGEM -38,854 -100.0%
IMVT -38,854 -100.0%
VRDN -30,986 -47.0%
CRNX -30,906 -24.0%
KROS -30,489 -100.0%
OLMA -23,125 -35.2%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type