Paradigm Biocapital Advisors LP

Q1 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
3/31/2025
Date filed
5/15/2025
Form type
13F-HR
Num holdings
28
Total value ($000)
$2,183,398
Net value change ($000)
-690,694 (-24.0%)
New positions
5
Sold out positions
6
Turnover %
13.9%
Sector allocation + QoQ delta (equities-only)
Prev filing: 2/14/2025 Next filing: 8/14/2025 SEC filing

Snapshot: Change Analysis

Compared to Q4 2024
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
Merus N.V. 70,770 99.6%
ONC 67,486 59.3%
CYTK 34,510 NEW
INSM 34,434 NEW
Metsera, Inc. 32,432 NEW
ARQT 22,918 NEW
LENZ 16,629 74.8%
COGT 15,336 40.0%
OCUL 9,632 NEW
Top Reduces (Value $000, Stocks/ETFs)
ARGX -260,681 -88.1%
JANX -98,338 -52.2%
MLTX -71,452 -74.5%
RVMD -68,175 -23.8%
VERA -60,785 -100.0%
PCVX -52,410 -45.0%
NUVL -46,137 -11.0%
PLRX -42,105 -100.0%
ACLX -40,581 -12.1%
IRON -34,842 -36.7%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 11,000 (0.5% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type