Paradigm Biocapital Advisors LP

Q2 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
6/30/2025
Date filed
8/14/2025
Form type
13F-HR
Num holdings
28
Total value ($000)
$2,342,122
Net value change ($000)
+158,724 (7.3%)
New positions
6
Sold out positions
5
Turnover %
15.6%
Sector allocation + QoQ delta (equities-only)
Prev filing: 5/15/2025 Next filing: 11/14/2025 SEC filing

Snapshot: Change Analysis

Compared to Q1 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
Merus N.V. 83,400 58.8%
SRRK 56,692 NEW
PCVX 45,592 71.2%
BBIO 41,702 NEW
ALKERMES PLC 39,355 NEW
AGIO 38,000 NEW
NUVL 28,350 7.6%
OCUL 22,109 229.5%
COGT 20,639 38.4%
PHVS 18,707 NEW
Top Reduces (Value $000, Stocks/ETFs)
ONC -97,083 -53.6%
ARGX -35,322 -100.0%
CYTK -34,510 -100.0%
INSM -34,434 -100.0%
Metsera, Inc. -32,432 -100.0%
ARQT -22,918 -100.0%
JANX -22,450 -25.0%
EWTX -16,154 -16.7%
TARS -13,524 -10.1%
SYRE -6,321 -18.4%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
Filter:
Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type