Paradigm Biocapital Advisors LP

Q3 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
9/30/2025
Date filed
11/14/2025
Form type
13F-HR
Num holdings
36
Total value ($000)
$3,516,197
Net value change ($000)
+1,174,075 (50.1%)
New positions
10
Sold out positions
5
Turnover %
21.7%
Sector allocation + QoQ delta (equities-only)
Prev filing: 8/14/2025 Next filing: 2/17/2026 SEC filing

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
Merus N.V. 186,559 82.8%
ABVX 132,800 NEW
GMAB 117,063 NEW
CDTX 92,041 NEW
URGN 84,111 NEW
ACLX 75,546 24.7%
AGIO 69,316 182.4%
RVMD 66,456 29.6%
NUVL 53,643 13.3%
CRNX 38,839 57.6%
Top Reduces (Value $000, Stocks/ETFs)
ONC -84,189 -100.0%
IRON -47,764 -74.5%
MLTX -41,457 -100.0%
COGT -29,005 -39.0%
Y-mAbs Therapeutics, Inc. -19,106 -100.0%
IMTX -16,916 -100.0%
CBIO -10,374 -100.0%
BBIO -6,161 -14.8%
SYRE -3,410 -12.2%
LENZ -325 -0.6%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 136,473 (3.9% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type