Frazier Life Sciences Management, L.P.

Q4 2023 13F-HR Holdings

Location
Palo Alto, CA
Holdings as of
12/31/2023
Date filed
2/14/2024
Form type
13F-HR
Num holdings
49
Total value ($000)
$1,870,349
Net value change ($000)
+364,690 (24.2%)
New positions
5
Sold out positions
7
Turnover %
6.0%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2023 Next filing: 5/15/2024 SEC filing

Snapshot: Change Analysis

Compared to Q3 2023
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
RYTM 54,647 100.5%
BBIO 38,164 53.1%
APLS 29,628 126.8%
ALPINE IMMUNE SCIENCES, INC. 25,490 74.6%
HilleVax, Inc. 25,432 19.3%
EWTX 24,314 499.8%
NAMS 23,293 20.8%
89bio, Inc. 22,340 NEW
RCKT 16,897 58.8%
MDGL 16,059 NEW
Top Reduces (Value $000, Stocks/ETFs)
CRNX -33,143 -70.1%
ARQT -17,805 -38.6%
ELVN -14,350 -100.0%
MIRM -12,720 -6.2%
PHAT -12,535 -12.0%
SNDX -8,712 -100.0%
REPL -6,617 -100.0%
PRTA -6,171 -100.0%
TRVI -5,110 -34.1%
COGT -2,906 -19.9%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type