Siren, L.L.C.
Q3 2025 13F-HR Holdings
Net value change ($000)
+623,857
(32.3%)
New positions
24
Sold out positions
19
Turnover %
11.3%
Sector allocation + QoQ delta (equities-only)
Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown
Snapshot: Change Analysis
Compared to Q2 2025
Methodology:
sector metrics are equities-only;
instrument mix chart is ex-options;
options exposure is shown separately.
Why this matters.
Top Adds (Value $000, Stocks/ETFs)
| ARWR | 49,900 | 118.3% |
| RZLT | 45,778 | NEW |
| ONC | 44,509 | 36.1% |
| KYMR | 44,429 | 29.7% |
| BCAX | 33,910 | 70.0% |
| CNTA | 32,802 | 72.1% |
| TNGX | 32,191 | 186.9% |
| GPCR | 28,751 | NEW |
| STOK | 27,306 | 107.1% |
| RAPP | 26,985 | 627.1% |
Top Reduces (Value $000, Stocks/ETFs)
| Merus N.V. | -44,892 | -100.0% |
| APGE | -25,841 | -100.0% |
| MLTX | -23,990 | -100.0% |
| AKRO | -17,003 | -100.0% |
| PCVX | -9,608 | -100.0% |
| SLNO | -7,562 | -19.3% |
| VERA | -5,824 | -100.0% |
| PCRX | -5,378 | -100.0% |
| GOOGL | -3,780 | -42.3% |
| IGM Biosciences, Inc. | -3,647 | -100.0% |
Instrument mix + QoQ Δ (ex-options)
How this table is calculated:
SEC
VALUE ($000) is used as reported.
For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received.
Column % is bucket-based:
non-options share is calculated inside non-option total, options share is calculated inside options total.
Details.
Filter:
Instrument:
| Issuer Name | Ticker | Sector | Industry | Class | History | Value ($000) | % | Shares | Shares Δ | Shares Δ% | Value Δ ($000) | Value Δ% | Principal | Option Type |
|---|