Siren, L.L.C.

Q4 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
12/31/2025
Date filed
2/13/2026
Form type
13F-HR
Num holdings
113
Total value ($000)
$3,352,425
Net value change ($000)
+796,132 (31.1%)
New positions
26
Sold out positions
28
Turnover %
17.5%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Prev filing: 11/13/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
SRRK 132,372 38.4%
OLMA 82,518 NEW
KYMR 61,715 31.8%
RVMD 57,597 118.2%
EWTX 49,201 77.8%
GPCR 46,272 160.9%
ZYME 44,238 NEW
DBVT 35,606 NEW
COGT 33,111 133.7%
RCUS 32,055 80.9%
Top Reduces (Value $000, Stocks/ETFs)
RNAM -56,014 -100.0%
RZLT -45,778 -100.0%
SLNO -31,592 -100.0%
NAMS -21,777 -100.0%
KRRO -17,273 -86.1%
QURE -16,063 -100.0%
ONC -16,057 -9.6%
AVBP -12,915 -100.0%
RAPP -9,793 -31.3%
LXRX -7,784 -14.8%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type