Siren, L.L.C.

Q2 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
6/30/2025
Date filed
8/13/2025
Form type
13F-HR
Num holdings
110
Total value ($000)
$1,932,436
Net value change ($000)
+159,656 (9.0%)
New positions
15
Sold out positions
21
Turnover %
10.0%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Prev filing: 5/23/2025 Next filing: 11/13/2025 SEC filing

Snapshot: Change Analysis

Compared to Q1 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
KYMR 60,917 68.7%
SRRK 30,247 10.2%
MLTX 23,990 NEW
LXRX 18,872 105.2%
DYN 17,613 62.0%
AKRO 17,003 NEW
TSHA 16,389 181.0%
AVBP 15,239 NEW
RVMD 14,603 73.3%
TNGX 13,713 390.1%
Top Reduces (Value $000, Stocks/ETFs)
BPMC -64,273 -100.0%
NAMS -17,511 -44.7%
PRTA -15,884 -100.0%
SMMT -13,407 -100.0%
SLNO -12,814 -24.7%
ONC -12,275 -9.0%
VERA -12,124 -67.6%
APLS -11,758 -20.9%
CRNX -8,072 -14.3%
WAVE LIFE SCIENCES LTD -5,840 -19.6%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type