Siren, L.L.C.

Q4 2025 13F-HR Detailed Holdings

Location
New York, NY
Holdings as of
12/31/2025
Date filed
2/13/2026
Form type
13F-HR
Num holdings
115
Total value ($000)
$3,352,425
Net value change ($000)
+796,132 (31.1%)
New positions
26
Sold out positions
28
Turnover %
17.5%
Sector allocation + QoQ delta (equities-only)

Holdings broken out by other managers reported in the original SEC filing. View aggregated holdings

Prev filing: 11/13/2025 Next filing: — SEC filing
You are on the SEC detailed breakdown page. Rows are shown as reported in the filing (including other manager, discretion, and voting authority fields), and are not merged like the standard holdings view. Switch to aggregated holdings.

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
SRRK 132,372 38.4%
OLMA 82,518 NEW
KYMR 61,715 31.8%
RVMD 57,597 118.2%
EWTX 49,201 77.8%
GPCR 46,272 160.9%
ZYME 44,238 NEW
DBVT 35,606 NEW
COGT 33,111 133.7%
RCUS 32,055 80.9%
Top Reduces (Value $000, Stocks/ETFs)
RNAM -56,014 -100.0%
RZLT -45,778 -100.0%
SLNO -31,592 -100.0%
NAMS -21,777 -100.0%
KRRO -17,273 -86.1%
QURE -16,063 -100.0%
ONC -16,057 -9.6%
AVBP -12,915 -100.0%
RAPP -9,793 -31.3%
LXRX -7,784 -14.8%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type Discretion Other Manager Sole Shared None

Other Managers

Num Name File Number
1 Invus Financial Advisors, LLC 028-19938
2 Invus Group, LLC 028-24462