Siren, L.L.C.

Q1 2026 13F-HR Detailed Holdings

Location
New York, NY
Holdings as of
3/31/2026
Date filed
5/14/2026
Form type
13F-HR
Num holdings
102
Total value ($000)
$3,607,379
Net value change ($000)
+254,954 (7.6%)
New positions
19
Sold out positions
32
Turnover %
19.1%
Sector allocation + QoQ delta (equities-only)

Holdings broken out by other managers reported in the original SEC filing. View aggregated holdings

You are on the SEC detailed breakdown page. Rows are shown as reported in the filing (including other manager, discretion, and voting authority fields), and are not merged like the standard holdings view. Switch to aggregated holdings.

Snapshot: Change Analysis

Compared to Q4 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
ERAS 149,355 458.5%
MANE 95,064 NEW
SRRK 55,316 11.6%
TNGX 46,002 63.6%
CYTK 40,466 NEW
XENE 40,246 110.5%
ORIC 29,745 360.9%
ELVN 29,252 NEW
BCAX 27,619 31.5%
EWTX 27,141 24.1%
Top Reduces (Value $000, Stocks/ETFs)
APLS -64,769 -100.0%
CNTA -58,884 -58.5%
ASND -50,295 -100.0%
RAPT -46,571 -100.0%
ZYME -44,238 -100.0%
DYN -28,104 -41.0%
MLYS -25,403 -100.0%
WAVE LIFE SCIENCES LTD -23,887 -57.4%
IHS -17,587 -100.0%
TSHA -16,245 -29.2%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type Discretion Other Manager Sole Shared None

Other Managers

Num Name File Number
1 Invus Financial Advisors, LLC 028-19938
2 Invus Group, LLC 028-24462