Siren, L.L.C.

Q1 2026 13F-HR Holdings

Location
New York, NY
Holdings as of
3/31/2026
Date filed
5/14/2026
Form type
13F-HR
Num holdings
100
Total value ($000)
$3,607,379
Net value change ($000)
+254,954 (7.6%)
New positions
19
Sold out positions
32
Turnover %
19.1%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Prev filing: 2/13/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q4 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
ERAS 149,355 458.5%
MANE 95,064 NEW
SRRK 55,316 11.6%
TNGX 46,002 63.6%
CYTK 40,466 NEW
XENE 40,246 110.5%
ORIC 29,745 360.9%
ELVN 29,252 NEW
BCAX 27,619 31.5%
EWTX 27,141 24.1%
Top Reduces (Value $000, Stocks/ETFs)
APLS -64,769 -100.0%
CNTA -58,884 -58.5%
ASND -50,295 -100.0%
RAPT -46,571 -100.0%
ZYME -44,238 -100.0%
DYN -28,104 -41.0%
MLYS -25,403 -100.0%
WAVE LIFE SCIENCES LTD -23,887 -57.4%
IHS -17,587 -100.0%
TSHA -16,245 -29.2%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type