ALPINE IMMUNE SCIENCES, INC. - 02083G100
Detailed investor-level table based on 13F positions.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | History | New | 5,775,000 | 228,921 | 2.67% | — | 1 | +5,775,000 | New | Q1 2024 | May 15, 2024 |
| Frazier Life Sciences Management, L.P. | History | No change | 3,131,008 | 124,113 | 5.24% | 3.19% | 2 | 0 | 0.0% | Q1 2024 | May 15, 2024 |
| STATE STREET CORP | History | Added to | 2,845,839 | 112,809 | 0.01% | 0.0% | 3 | +1,455,810 | 104.73% | Q1 2024 | May 15, 2024 |
| VANGUARD GROUP INC | History | Added to | 2,712,285 | 107,514 | 0.0% | 0.0% | 4 | +477,518 | 21.37% | Q1 2024 | May 10, 2024 |
| ORBIMED ADVISORS LLC | History | Added to | 2,680,496 | 106,254 | 1.95% | 0.97% | 5 | +145,251 | 5.73% | Q1 2024 | May 15, 2024 |
| Paradigm Biocapital Advisors LP | History | Reduced | 2,121,163 | 84,082 | 2.96% | 2.83% | 6 | -1,055,580 | -33.23% | Q1 2024 | May 15, 2024 |
| Darwin Global Management, Ltd. | History | New | 1,982,016 | 78,567 | 10.46% | — | 7 | +1,982,016 | New | Q1 2024 | May 15, 2024 |
| FRANKLIN RESOURCES INC | History | Reduced | 1,093,203 | 43,334 | 0.01% | 0.01% | 8 | -127,130 | -10.42% | Q1 2024 | May 13, 2024 |
| GEODE CAPITAL MANAGEMENT, LLC | History | Added to | 910,599 | 36,101 | 0.0% | 0.0% | 9 | +146,252 | 19.13% | Q1 2024 | May 13, 2024 |
| MORGAN STANLEY | History | Added to | 789,645 | 31,301 | 0.0% | 0.0% | 10 | +70,904 | 9.87% | Q1 2024 | Oct 17, 2024 |
| TWO SIGMA ADVISERS, LP | History | Added to | 668,775 | 26,510 | 0.06% | 0.01% | 11 | +404,700 | 153.25% | Q1 2024 | May 15, 2024 |
| TWO SIGMA INVESTMENTS, LP | History | Added to | 519,971 | 20,611 | 0.05% | 0.02% | 12 | +141,558 | 37.41% | Q1 2024 | May 15, 2024 |
| JANUS HENDERSON GROUP PLC | History | Reduced | 450,827 | 17,839 | 0.01% | 0.01% | 13 | -132,412 | -22.7% | Q1 2024 | May 15, 2024 |
| Candriam S.C.A. | History | Reduced | 415,000 | 16,450 | 0.11% | 0.06% | 14 | -55,000 | -11.7% | Q1 2024 | May 06, 2024 |
| EVENTIDE ASSET MANAGEMENT, LLC | History | New | 408,542 | 16,194 | 0.25% | — | 15 | +408,542 | New | Q1 2024 | May 15, 2024 |
| BALYASNY ASSET MANAGEMENT L.P. | History | New | 372,995 | 14,785 | 0.03% | — | 16 | +372,995 | New | Q1 2024 | May 13, 2024 |
| NORTHERN TRUST CORP | History | Added to | 341,701 | 13,545 | 0.0% | 0.0% | 17 | +45,006 | 15.17% | Q1 2024 | May 14, 2024 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | History | Added to | 339,142 | 13,443 | 0.0% | 0.0% | 18 | +41,690 | 14.02% | Q1 2024 | May 09, 2024 |
| Bank of New York Mellon Corp | History | Added to | 325,943 | 12,920 | 0.0% | 0.0% | 19 | +223,591 | 218.45% | Q1 2024 | Apr 25, 2024 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | History | Reduced | 310,000 | 12,288 | 0.02% | 0.03% | 20 | -404,590 | -56.62% | Q1 2024 | May 15, 2024 |
| Invesco Ltd. | History | Added to | 272,627 | 10,806 | 0.0% | 0.0% | 21 | +30,851 | 12.76% | Q1 2024 | May 14, 2024 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | History | Added to | 267,232 | 10,593 | 0.04% | 0.02% | 22 | +33,482 | 14.32% | Q1 2024 | May 15, 2024 |
| Woodline Partners LP | History | Reduced | 254,334 | 10,081 | 0.09% | 0.21% | 23 | -745,772 | -74.57% | Q1 2024 | May 15, 2024 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | History | Added to | 247,760 | 9,821 | 0.0% | 0.0% | 24 | +224,985 | 987.86% | Q1 2024 | May 07, 2024 |
| RENAISSANCE TECHNOLOGIES LLC | History | Added to | 244,981 | 9,711 | 0.02% | 0.01% | 25 | +28,296 | 13.06% | Q1 2024 | May 13, 2024 |
| GOLDMAN SACHS GROUP INC | History | Added to | 240,435 | 9,530 | 0.0% | 0.0% | 26 | +42,491 | 21.47% | Q1 2024 | May 15, 2024 |
| FMR LLC | History | Added to | 238,561 | 9,456 | 0.0% | 0.0% | 27 | +15 | 0.01% | Q1 2024 | May 13, 2024 |
| Rafferty Asset Management, LLC | History | Added to | 234,625 | 9,300 | 0.03% | 0.01% | 28 | +154,463 | 192.69% | Q1 2024 | May 13, 2024 |
| CITADEL ADVISORS LLC | History | Reduced | 215,479 | 8,541 | 0.0% | 0.0% | 29 | -667,378 | -75.59% | Q1 2024 | May 15, 2024 |
| CITIGROUP INC | History | Added to | 207,496 | 8,225 | 0.01% | 0.0% | 30 | +171,719 | 479.97% | Q1 2024 | May 10, 2024 |
| Walleye Capital LLC | History | Reduced | 207,304 | 8,217 | 0.01% | 0.01% | 31 | -158,636 | -43.35% | Q1 2024 | May 15, 2024 |
| DEUTSCHE BANK AG\ | History | Added to | 204,479 | 8,105 | 0.0% | 0.0% | 32 | +75,000 | 57.92% | Q1 2024 | Jun 02, 2025 |
| BANK OF AMERICA CORP /DE/ | History | Added to | 202,414 | 8,023 | 0.02% | 0.0% | 33 | +110,648 | 120.58% | Q1 2024 | Mar 18, 2025 |
| JENNISON ASSOCIATES LLC | History | Added to | 191,974 | 7,609 | 0.01% | 0.0% | 34 | +50,879 | 36.06% | Q1 2024 | May 02, 2024 |
| DIMENSIONAL FUND ADVISORS LP | History | Reduced | 191,779 | 7,602 | 0.0% | 0.0% | 35 | -42,102 | -18.0% | Q1 2024 | May 10, 2024 |
| JANE STREET GROUP, LLC | History | Added to | 177,434 | 7,033 | 0.0% | 0.0% | 36 | +107,981 | 155.47% | Q1 2024 | May 16, 2024 |
| ExodusPoint Capital Management, LP | History | Reduced | 171,251 | 6,788 | 0.05% | 0.03% | 37 | -37,723 | -18.05% | Q1 2024 | May 14, 2024 |
| Qube Research & Technologies Ltd | History | Reduced | 163,323 | 6,474 | 0.01% | 0.01% | 38 | -42,443 | -20.63% | Q1 2024 | May 14, 2024 |
| WELLINGTON MANAGEMENT GROUP LLP | History | Added to | 161,145 | 6,387 | 0.0% | 0.35% | 39 | +51,263 | 46.65% | Q1 2024 | May 15, 2024 |
| UBS Group AG | History | Added to | 153,473 | 6,083 | 0.0% | 0.0% | 40 | +87,666 | 133.22% | Q1 2024 | May 13, 2024 |
| Ensign Peak Advisors, Inc | History | Added to | 140,043 | 5,551 | 0.01% | 0.0% | 41 | +10,068 | 7.75% | Q1 2024 | May 14, 2024 |
| FEDERATED HERMES, INC. | History | Added to | 138,981 | 5,509 | 0.01% | 0.0% | 42 | +138,616 | 37976.99% | Q1 2024 | May 14, 2024 |
| Hillsdale Investment Management Inc. | History | New | 133,960 | 5,310 | 0.42% | — | 43 | +133,960 | New | Q1 2024 | May 10, 2024 |
| TD ASSET MANAGEMENT INC | History | Added to | 118,418 | 4,694 | 0.0% | 0.0% | 44 | +85,218 | 256.68% | Q1 2024 | May 08, 2024 |
| Trexquant Investment LP | History | Added to | 115,776 | 4,589 | 0.09% | 0.02% | 45 | +61,996 | 115.28% | Q1 2024 | May 14, 2024 |
| Point72 Asset Management, L.P. | History | New | 110,700 | 4,388 | 0.01% | — | 46 | +110,700 | New | Q1 2024 | May 15, 2024 |
| BOOTHBAY FUND MANAGEMENT, LLC | History | Reduced | 97,872 | 3,879 | 0.07% | 0.06% | 47 | -18,951 | -16.22% | Q1 2024 | May 15, 2024 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | History | Added to | 83,868 | 3,324 | 0.0% | 0.0% | 48 | +57,090 | 213.2% | Q1 2024 | May 14, 2024 |
| BAKER BROS. ADVISORS LP | History | New | 81,578 | 3,233 | 0.04% | — | 49 | +81,578 | New | Q1 2024 | May 15, 2024 |
| BNP PARIBAS FINANCIAL MARKETS | History | Reduced | 77,784 | 3,083 | 0.0% | 0.0% | 50 | -29,157 | -27.26% | Q1 2024 | May 01, 2024 |
| Swiss National Bank | History | Added to | 63,500 | 2,517 | 0.0% | 0.0% | 51 | +6,300 | 11.01% | Q1 2024 | May 07, 2024 |
| RHUMBLINE ADVISERS | History | Added to | 54,543 | 2,162 | 0.0% | 0.0% | 52 | +10,822 | 24.75% | Q1 2024 | May 09, 2024 |
| TUDOR INVESTMENT CORP ET AL | History | New | 50,729 | 2,010 | 0.01% | — | 53 | +50,729 | New | Q1 2024 | May 15, 2024 |
| BARCLAYS PLC | History | Reduced | 49,170 | 1,949 | 0.0% | 0.0% | 54 | -31,127 | -38.76% | Q1 2024 | Mar 24, 2026 |
| ALPS ADVISORS INC | History | Added to | 46,222 | 1,832 | 0.01% | 0.01% | 55 | +6,631 | 16.75% | Q1 2024 | May 14, 2024 |
| VICTORY CAPITAL MANAGEMENT INC | History | New | 45,064 | 1,786 | 0.0% | — | 56 | +45,064 | New | Q1 2024 | May 03, 2024 |
| ALLIANCEBERNSTEIN L.P. | History | Added to | 41,290 | 1,636 | 0.0% | 0.0% | 57 | +11,250 | 37.45% | Q1 2024 | May 14, 2024 |
| CAPSTONE INVESTMENT ADVISORS, LLC | History | Added to | 38,212 | 1,514 | 0.01% | 0.0% | 58 | +12,923 | 51.1% | Q1 2024 | May 01, 2024 |
| UBS ASSET MANAGEMENT AMERICAS LLC | History | Added to | 37,925 | 1,503 | 0.0% | 0.0% | 59 | +25,916 | 215.8% | Q1 2024 | May 15, 2024 |
| Jefferies Financial Group Inc. | History | Reduced | 35,000 | 1,387 | 0.01% | 0.01% | 60 | -65,152 | -65.05% | Q1 2024 | May 13, 2024 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | History | Added to | 32,823 | 1,301 | 0.0% | 0.0% | 61 | +1,660 | 5.33% | Q1 2024 | May 16, 2024 |
| Legal & General Group Plc | History | Added to | 30,901 | 1,224 | 0.0% | 0.0% | 62 | +4,638 | 17.66% | Q1 2024 | May 29, 2025 |
| STATE OF WISCONSIN INVESTMENT BOARD | History | Added to | 30,133 | 1,194 | 0.0% | 0.0% | 63 | +1,184 | 4.09% | Q1 2024 | May 14, 2024 |
| JPMORGAN CHASE & CO | History | Reduced | 29,459 | 1,167 | 0.0% | 0.0% | 64 | -3,615 | -10.93% | Q1 2024 | Dec 26, 2024 |
| Capula Management Ltd | History | New | 23,970 | 950 | 0.02% | — | 65 | +23,970 | New | Q1 2024 | May 09, 2024 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | History | No change | 23,566 | 934 | 0.01% | 0.01% | 66 | 0 | 0.0% | Q1 2024 | May 15, 2024 |
| Boston Partners | History | New | 23,101 | 915 | 0.0% | — | 67 | +23,101 | New | Q1 2024 | May 28, 2024 |
| OPPENHEIMER & CO INC | History | New | 21,538 | 853 | 0.01% | — | 68 | +21,538 | New | Q1 2024 | May 07, 2024 |
| VOYA INVESTMENT MANAGEMENT LLC | History | Added to | 21,475 | 851 | 0.0% | 0.0% | 69 | +8,422 | 64.52% | Q1 2024 | Feb 07, 2025 |
| SIMPLEX TRADING, LLC | History | New | 21,123 | 837 | 0.0% | — | 70 | +21,123 | New | Q1 2024 | Apr 25, 2024 |
| SEI INVESTMENTS CO | History | Reduced | 20,058 | 795 | 0.0% | 0.0% | 71 | -3,153 | -13.58% | Q1 2024 | May 07, 2024 |
| FIRST TRUST ADVISORS LP | History | New | 19,836 | 786 | 0.0% | — | 72 | +19,836 | New | Q1 2024 | May 13, 2024 |
| MetLife Investment Management, LLC | History | Added to | 19,701 | 780 | 0.01% | 0.75% | 73 | +2,883 | 17.14% | Q1 2024 | May 14, 2024 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | History | New | 18,982 | 752 | 0.0% | — | 74 | +18,982 | New | Q1 2024 | May 15, 2024 |
| AQR CAPITAL MANAGEMENT LLC | History | Reduced | 18,079 | 716 | 0.0% | 0.0% | 75 | -8,891 | -32.97% | Q1 2024 | May 15, 2024 |
| NEW YORK STATE COMMON RETIREMENT FUND | History | Added to | 17,657 | 699 | 0.0% | 0.0% | 76 | +2,782 | 18.7% | Q1 2024 | Oct 08, 2025 |
| OMERS ADMINISTRATION Corp | History | New | 15,400 | 610 | 0.01% | — | 77 | +15,400 | New | Q1 2024 | May 14, 2024 |
| BANK OF MONTREAL /CAN/ | History | New | 14,645 | 589 | 0.0% | — | 78 | +14,645 | New | Q1 2024 | May 13, 2024 |
| MILLENNIUM MANAGEMENT LLC | History | Reduced | 14,438 | 572 | 0.0% | 0.0% | 79 | -258,628 | -94.71% | Q1 2024 | May 15, 2024 |
| Connor, Clark & Lunn Investment Management Ltd. | History | Added to | 13,357 | 529 | 0.0% | 0.0% | 80 | +1,448 | 12.16% | Q1 2024 | May 09, 2024 |
| Belvedere Trading LLC | History | New | 12,870 | 510 | 0.0% | — | 81 | +12,870 | New | Q1 2024 | May 09, 2024 |
| WELLS FARGO & COMPANY/MN | History | Added to | 12,526 | 496 | 0.0% | 0.0% | 82 | +3,290 | 35.62% | Q1 2024 | May 10, 2024 |
| ProShare Advisors LLC | History | New | 11,502 | 455 | 0.0% | — | 83 | +11,502 | New | Q1 2024 | May 08, 2024 |
| Mirae Asset Global Investments Co., Ltd. | History | Reduced | 14,430 | 397 | 0.0% | 0.0% | 84 | -5,747 | -28.48% | Q1 2024 | May 01, 2024 |
| Arizona State Retirement System | History | New | 8,849 | 350 | 0.0% | — | 85 | +8,849 | New | Q1 2024 | May 07, 2024 |
| Gotham Asset Management, LLC | History | New | 8,773 | 347 | 0.01% | — | 86 | +8,773 | New | Q1 2024 | May 15, 2024 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | History | Reduced | 8,006 | 317 | 0.0% | 0.0% | 87 | -1,532 | -16.06% | Q1 2024 | Apr 25, 2024 |
| LAZARD ASSET MANAGEMENT LLC | History | Added to | 7,518 | 298 | 0.0% | 0.0% | 88 | +2,110 | 39.02% | Q1 2024 | Jul 09, 2024 |
| TEACHER RETIREMENT SYSTEM OF TEXAS | History | New | 7,165 | 284 | 0.0% | — | 89 | +7,165 | New | Q1 2024 | May 06, 2024 |
| Allspring Global Investments Holdings, LLC | History | Added to | 6,414 | 254 | 0.0% | 0.0% | 90 | +4,926 | 331.05% | Q1 2024 | Apr 29, 2024 |
| COMMONWEALTH EQUITY SERVICES, LLC | History | New | 6,210 | 246 | 0.0% | — | 91 | +6,210 | New | Q1 2024 | Apr 29, 2024 |
| FARALLON CAPITAL MANAGEMENT LLC | History | New | 5,900 | 233 | 0.25% | — | 92 | +5,900 | New | Q1 2024 | Nov 14, 2025 |
| GLENMEDE TRUST CO NA | History | New | 5,780 | 229 | 0.0% | — | 93 | +5,780 | New | Q1 2024 | May 15, 2024 |
| US BANCORP \DE\ | History | New | 3,240 | 128 | 0.0% | — | 94 | +3,240 | New | Q1 2024 | May 08, 2024 |
| STRS OHIO | History | New | 1,900 | 75 | 0.0% | — | 95 | +1,900 | New | Q1 2024 | May 13, 2024 |
| ROYAL BANK OF CANADA | History | Reduced | 1,611 | 64 | 0.0% | 0.0% | 96 | -8,533 | -84.12% | Q1 2024 | Nov 05, 2024 |
| Aquatic Capital Management LLC | History | Reduced | 1,200 | 47 | 0.0% | 0.0% | 97 | -200 | -14.29% | Q1 2024 | May 15, 2024 |
| Pacer Advisors, Inc. | History | New | 1,095 | 43 | 0.0% | — | 98 | +1,095 | New | Q1 2024 | May 10, 2024 |
| Tower Research Capital LLC (TRC) | History | Reduced | 711 | 28 | 0.0% | 0.0% | 99 | -4,779 | -87.05% | Q1 2024 | May 15, 2024 |
| Russell Investments Group, Ltd. | History | New | 691 | 27 | 0.0% | — | 101 | +691 | New | Q1 2024 | May 08, 2024 |
| GROUP ONE TRADING, L.P. | History | Added to | 699 | 27 | 0.0% | 0.0% | 100 | +425 | 155.11% | Q1 2024 | May 10, 2024 |
| OSAIC HOLDINGS, INC. | History | Added to | 651 | 25 | 0.0% | 0.0% | 102 | +33 | 5.34% | Q1 2024 | May 10, 2024 |
| NewEdge Advisors, LLC | History | No change | 469 | 18 | 0.0% | 0.0% | 103 | 0 | 0.0% | Q1 2024 | May 14, 2024 |
| PNC FINANCIAL SERVICES GROUP, INC. | History | New | 54 | 2 | 0.0% | — | 104 | +54 | New | Q1 2024 | May 10, 2024 |
| NISA INVESTMENT ADVISORS, LLC | History | Added to | 45 | 1 | 0.0% | — | 105 | +33 | 275.0% | Q1 2024 | May 02, 2024 |
| RA CAPITAL MANAGEMENT, L.P. | History | Closed out | 0 | 0 | — | 1.46% | — | -4,909,763 | -100.0% | Q4 2023 | Feb 14, 2024 |
| D. E. Shaw & Co., Inc. | History | Closed out | 0 | 0 | — | 25.58% | — | -295,542 | -100.0% | Q4 2023 | Nov 14, 2024 |
| MARSHALL WACE, LLP | History | Closed out | 0 | 0 | — | 0.01% | — | -221,118 | -100.0% | Q4 2023 | Feb 14, 2024 |
| Hudson Bay Capital Management LP | History | Closed out | 0 | 0 | — | 0.02% | — | -197,019 | -100.0% | Q4 2023 | Feb 14, 2024 |
| Jump Financial, LLC | History | Closed out | 0 | 0 | — | 1.06% | — | -55,720 | -100.0% | Q4 2023 | Oct 21, 2024 |
| Walleye Trading LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -25,596 | -100.0% | Q4 2023 | Feb 14, 2024 |
| Squarepoint Ops LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -21,878 | -100.0% | Q4 2023 | Feb 14, 2024 |
| PRINCIPAL SECURITIES, INC. | History | New | 6 | 0 | — | — | — | +6 | New | Q1 2024 | May 10, 2024 |
| Farther Finance Advisors, LLC | History | No change | 20 | 0 | — | — | — | 0 | 0.0% | Q1 2024 | May 14, 2024 |