LEXICON PHARMACEUTICALS, INC. - LXRX

Detailed investor-level table based on 13F positions.
Early Q1 2026 data: only 14 institutional holders reported so far. The full shareholder list will grow as more funds file with the SEC.

Shareholders (13F)

Quarter: Q4 2025 · Compare: Q3 2025
13D/13G major owners: Ownership tab.
Methodology: Market value and % of portfolio use SEC reported VALUE ($000). For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received. Details.
Rows: 0
Investor History Status Shares held Market value ($000) % of portfolio Previous % Rank Change in shares % change in shares Source Date reported
Artal Group S.A. History No change 136,180,481 156,607 21.91% 24.25% 1 0 0.0% Q4 2025 Feb 12, 2026
Siren, L.L.C. History No change 38,918,903 44,756 1.34% 2.06% 2 0 0.0% Q4 2025 Feb 13, 2026
FMR LLC History Reduced 37,834,207 43,509 0.0% 0.0% 3 -845,541 -2.19% Q4 2025 Feb 17, 2026
VANGUARD GROUP INC History Added to 9,606,549 11,047 0.0% 0.0% 4 +84,675 0.89% Q4 2025 Jan 29, 2026
MILLENNIUM MANAGEMENT LLC History Added to 4,821,733 5,544 0.0% 0.0% 5 +991,073 25.87% Q4 2025 Feb 17, 2026
BlackRock, Inc. History Reduced 3,192,448 3,671 0.0% 0.0% 6 -202,524 -5.97% Q4 2025 Feb 12, 2026
UBS Group AG History Added to 3,007,237 3,458 0.0% 0.0% 7 +2,654,315 752.1% Q4 2025 Jan 29, 2026
Sessa Capital IM, L.P. History No change 3,000,000 3,450 0.06% 0.1% 8 0 0.0% Q4 2025 Feb 17, 2026
GEODE CAPITAL MANAGEMENT, LLC History Added to 2,500,022 2,876 0.0% 0.0% 9 +102,099 4.26% Q4 2025 Feb 09, 2026
CITADEL ADVISORS LLC History Reduced 2,269,075 2,609 0.0% 0.0% 10 -819,152 -26.52% Q4 2025 Feb 17, 2026
CIBC Private Wealth Group LLC History Reduced 1,950,000 2,242 0.0% 0.01% 11 -450,257 -18.76% Q4 2025 Feb 12, 2026
JANE STREET GROUP, LLC History Added to 1,828,404 2,102 0.0% 0.0% 12 +1,360,574 290.83% Q4 2025 Feb 12, 2026
SUSQUEHANNA INTERNATIONAL GROUP, LLP History Added to 1,543,242 1,774 0.0% 0.0% 13 +333,982 27.62% Q4 2025 Feb 17, 2026
MARSHALL WACE, LLP History New 1,262,367 1,451 0.0% 14 +1,262,367 New Q4 2025 Feb 13, 2026
CHARLES SCHWAB INVESTMENT MANAGEMENT INC History Reduced 1,055,123 1,213 0.0% 0.0% 15 -89,509 -7.82% Q4 2025 Feb 13, 2026
GSA CAPITAL PARTNERS LLP History Reduced 996,235 1,146 0.1% 0.14% 16 -206,671 -17.18% Q4 2025 Feb 06, 2026
GOLDMAN SACHS GROUP INC History Added to 921,204 1,059 0.0% 0.0% 17 +861,857 1452.23% Q4 2025 Mar 25, 2026
Hennion & Walsh Asset Management, Inc. History Added to 901,222 1,036 0.04% 0.04% 18 +122,010 15.66% Q4 2025 Jan 14, 2026
STATE STREET CORP History Added to 884,738 1,017 0.0% 0.0% 19 +4,617 0.52% Q4 2025 Feb 13, 2026
Ishara Investments LP History New 880,000 1,012 1.16% 20 +880,000 New Q4 2025 Feb 17, 2026
ACADIAN ASSET MANAGEMENT LLC History Added to 640,130 732 0.0% 0.0% 21 +603,225 1634.53% Q4 2025 Feb 10, 2026
TWO SIGMA INVESTMENTS, LP History Added to 637,308 732 0.0% 0.0% 22 +78,300 14.01% Q4 2025 Feb 17, 2026
Invesco Ltd. History Added to 594,883 684 0.0% 0.0% 23 +73,480 14.09% Q4 2025 Feb 19, 2026
NORTHERN TRUST CORP History Added to 412,164 473 0.0% 0.0% 24 +42,370 11.46% Q4 2025 Feb 17, 2026
Compagnie Lombard Odier SCmA History No change 410,000 471 0.01% 0.01% 25 0 0.0% Q4 2025 Jan 16, 2026
Point72 Asset Management, L.P. History New 284,025 326 0.0% 26 +284,025 New Q4 2025 Feb 17, 2026
OMERS ADMINISTRATION Corp History New 273,800 314 0.0% 27 +273,800 New Q4 2025 Feb 13, 2026
ExodusPoint Capital Management, LP History New 268,433 308 0.0% 28 +268,433 New Q4 2025 Feb 17, 2026
RENAISSANCE TECHNOLOGIES LLC History Reduced 263,254 302 0.0% 0.0% 29 -29,146 -9.97% Q4 2025 Feb 12, 2026
GROUP ONE TRADING LLC History Added to 224,308 257 0.0% 0.0% 30 +8,064 3.73% Q4 2025 Feb 12, 2026
BARCLAYS PLC History Added to 194,743 223 0.0% 0.0% 31 +162,881 511.21% Q4 2025 Feb 13, 2026
MORGAN STANLEY History Added to 193,035 221 0.0% 0.0% 32 +24,017 14.21% Q4 2025 Feb 13, 2026
TWO SIGMA ADVISERS, LP History New 180,977 208 0.0% 33 +180,977 New Q4 2025 Feb 17, 2026
Ikarian Capital, LLC History Reduced 164,674 189 0.01% 0.02% 34 -11,805 -6.69% Q4 2025 Feb 18, 2026
AQR CAPITAL MANAGEMENT LLC History Reduced 144,800 166 0.0% 0.0% 35 -158,131 -52.2% Q4 2025 Feb 17, 2026
Cerity Partners LLC History Reduced 144,944 166 0.0% 0.0% 36 -13,096 -8.29% Q4 2025 Feb 11, 2026
Headlands Technologies LLC History Added to 136,113 156 0.01% 0.01% 37 +86,466 174.16% Q4 2025 Feb 13, 2026
Lighthouse Investment Partners, LLC History New 126,600 145 0.0% 38 +126,600 New Q4 2025 Feb 17, 2026
HRT FINANCIAL LP History Added to 117,549 135 0.0% 0.0% 39 +71,102 153.08% Q4 2025 Feb 12, 2026
Monaco Asset Management SAM History Reduced 117,188 134 0.02% 0.03% 40 -232,812 -66.52% Q4 2025 Feb 10, 2026
TWO SIGMA SECURITIES, LLC History Added to 114,632 131 0.02% 0.0% 41 +98,751 621.82% Q4 2025 Feb 17, 2026
Graham Capital Management, L.P. History New 109,900 126 0.0% 42 +109,900 New Q4 2025 Feb 17, 2026
BANK OF AMERICA CORP /DE/ History Added to 102,097 117 0.0% 0.0% 43 +44,293 76.63% Q4 2025 Feb 17, 2026
Hudson Bay Capital Management LP History New 100,532 115 0.0% 44 +100,532 New Q4 2025 Feb 13, 2026
XTX Topco Ltd History Reduced 96,090 110 0.0% 0.02% 45 -233,446 -70.84% Q4 2025 Feb 17, 2026
Jefferies Financial Group Inc. History Reduced 92,530 106 0.0% 0.0% 46 -4,870 -5.0% Q4 2025 Feb 09, 2026
CITIGROUP INC History Added to 91,670 105 0.0% 0.0% 47 +73,551 405.93% Q4 2025 Feb 13, 2026
Quarry LP History New 88,000 101 0.02% 48 +88,000 New Q4 2025 Feb 13, 2026
LPL Financial LLC History Reduced 87,057 100 0.0% 0.0% 49 -4,201 -4.6% Q4 2025 Feb 11, 2026
CAXTON ASSOCIATES LLP History New 71,027 81 0.0% 50 +71,027 New Q4 2025 Feb 13, 2026
BANK OF MONTREAL /CAN/ History No change 70,000 80 0.0% 0.0% 51 0 0.0% Q4 2025 Feb 12, 2026
Vanguard Personalized Indexing Management, LLC History No change 66,567 76 0.0% 0.0% 52 0 0.0% Q4 2025 Feb 13, 2026
Straight Path Wealth Management History No change 62,666 72 0.02% 0.02% 53 0 0.0% Q4 2025 Feb 11, 2026
State of Wyoming History Added to 60,571 69 0.01% 0.0% 55 +52,045 610.43% Q4 2025 Feb 11, 2026
Squarepoint Ops LLC History Added to 60,472 69 0.0% 0.0% 54 +1,796 3.06% Q4 2025 Feb 13, 2026
Optiver Holding B.V. History Reduced 52,595 60 0.0% 0.0% 56 -23,298 -30.7% Q4 2025 Feb 17, 2026
Fortis Group Advisors, LLC History Reduced 50,000 58 0.01% 0.01% 57 -7,800 -13.49% Q4 2025 Feb 06, 2026
R Squared Ltd History Added to 46,579 53 0.02% 0.02% 58 +14,530 45.34% Q4 2025 Jan 30, 2026
BOOTHBAY FUND MANAGEMENT, LLC History Reduced 44,315 50 0.0% 0.0% 59 -11,805 -21.04% Q4 2025 Feb 17, 2026
WEDBUSH SECURITIES INC History No change 40,850 47 0.0% 0.0% 60 0 0.0% Q4 2025 Feb 12, 2026
KWB Wealth History No change 40,640 46 0.0% 0.0% 61 0 0.0% Q4 2025 Jan 12, 2026
Catalyst Funds Management Pty Ltd History No change 40,300 46 0.01% 0.01% 62 0 0.0% Q4 2025 Feb 09, 2026
CIBC Asset Management Inc History New 39,520 45 0.0% 63 +39,520 New Q4 2025 Feb 10, 2026
Virtu Financial LLC History New 36,468 42 0.0% 64 +36,468 New Q4 2025 Feb 23, 2026
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO History No change 35,714 41 0.01% 0.01% 65 0 0.0% Q4 2025 Feb 17, 2026
EntryPoint Capital, LLC History New 33,618 38 0.01% 67 +33,618 New Q4 2025 Feb 12, 2026
PRUDENTIAL FINANCIAL INC History Reduced 33,800 38 0.0% 0.0% 66 -1,200 -3.43% Q4 2025 Feb 13, 2026
Vermillion & White Wealth Management Group, LLC History Reduced 32,000 36 0.02% 0.02% 68 -500 -1.54% Q4 2025 Feb 18, 2026
Leonteq Securities AG History New 30,000 34 0.0% 69 +30,000 New Q4 2025 Feb 06, 2026
Pathstone Holdings, LLC History New 29,969 34 0.0% 70 +29,969 New Q4 2025 Feb 13, 2026
PINNACLE ASSOCIATES LTD History Reduced 29,015 33 0.0% 0.0% 71 -21,800 -42.9% Q4 2025 Feb 05, 2026
Tower Research Capital LLC (TRC) History Added to 29,093 33 0.0% 0.0% 72 +5,414 22.86% Q4 2025 Feb 17, 2026
SECURITY NATIONAL BANK OF SIOUX CITY IOWA /IA/ History New 26,650 30 0.02% 73 +26,650 New Q4 2025 Feb 13, 2026
OPPENHEIMER & CO INC History No change 23,500 27 0.0% 0.0% 74 0 0.0% Q4 2025 Feb 02, 2026
Cambridge Investment Research Advisors, Inc. History Reduced 21,505 25 0.0% 0.0% 75 -1,895 -8.1% Q4 2025 Feb 05, 2026
VICTORY CAPITAL MANAGEMENT INC History Added to 21,191 24 0.0% 0.0% 76 +168 0.8% Q4 2025 Feb 13, 2026
Invera Wealth Advisors, LLC History No change 20,000 23 0.01% 0.02% 77 0 0.0% Q4 2025 Jan 23, 2026
TIAA TRUST, NATIONAL ASSOCIATION History No change 20,000 23 0.0% 0.0% 78 0 0.0% Q4 2025 Feb 11, 2026
Quadrature Capital Ltd History Reduced 18,414 21 0.0% 0.0% 81 -209,795 -91.93% Q4 2025 Feb 17, 2026
CREDIT AGRICOLE S A History New 18,975 21 0.0% 79 +18,975 New Q4 2025 Feb 17, 2026
Bank of New York Mellon Corp History No change 19,124 21 0.0% 0.0% 80 0 0.0% Q4 2025 Feb 10, 2026
StoneX Group Inc. History New 16,234 18 0.0% 82 +16,234 New Q4 2025 Feb 12, 2026
SIMPLEX TRADING, LLC History Reduced 14,758 16 0.0% 0.0% 85 -58,529 -79.86% Q4 2025 Feb 11, 2026
LAZARD ASSET MANAGEMENT LLC History New 14,090 16 0.0% 84 +14,090 New Q4 2025 Feb 17, 2026
Callan Family Office, LLC History New 14,090 16 0.0% 87 +14,090 New Q4 2025 Feb 12, 2026
Cetera Investment Advisers History Reduced 14,188 16 0.0% 0.0% 86 -3,336 -19.04% Q4 2025 Feb 17, 2026
TRUIST FINANCIAL CORP History No change 14,000 16 0.0% 0.0% 83 0 0.0% Q4 2025 Feb 02, 2026
Schonfeld Strategic Advisors LLC History Reduced 13,108 15 0.0% 0.01% 90 -812,525 -98.41% Q4 2025 Feb 17, 2026
CWM, LLC History Reduced 13,179 15 0.0% 0.0% 88 -13,565 -50.72% Q4 2025 Jan 26, 2026
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC History Reduced 13,520 15 0.0% 0.0% 89 -5,357 -28.38% Q4 2025 Jan 08, 2026
HBK Sorce Advisory LLC History No change 11,786 14 0.0% 0.0% 91 0 0.0% Q4 2025 Feb 09, 2026
CAPTRUST FINANCIAL ADVISORS History Reduced 11,735 13 0.0% 0.0% 92 -2,334 -16.59% Q4 2025 Feb 17, 2026
Chemistry Wealth Management LLC History No change 12,000 13 0.0% 0.0% 93 0 0.0% Q4 2025 Jan 06, 2026
Perennial Investment Advisors, LLC History No change 10,990 12 0.0% 0.0% 94 0 0.0% Q4 2025 Feb 17, 2026
Berger Financial Group, Inc History Reduced 10,000 11 0.0% 0.0% 96 -929 -8.5% Q4 2025 Jan 27, 2026
NBT BANK N A /NY History No change 10,000 11 0.0% 0.0% 95 0 0.0% Q4 2025 Jan 23, 2026
ROYAL BANK OF CANADA History New 6,768 7 0.0% 97 +6,768 New Q4 2025 Feb 17, 2026
Golden State Wealth Management, LLC History No change 3,700 4 0.0% 0.0% 98 0 0.0% Q4 2025 Feb 13, 2026
SBI Securities Co., Ltd. History Reduced 3,018 3 0.0% 0.0% 99 -12,029 -79.94% Q4 2025 Feb 03, 2026
Farther Finance Advisors, LLC History Added to 2,755 3 0.0% 0.0% 100 +1,500 119.52% Q4 2025 Jan 23, 2026
NISA INVESTMENT ADVISORS, LLC History No change 2,592 2 0.0% 0.0% 101 0 0.0% Q4 2025 Jan 15, 2026
JONES FINANCIAL COMPANIES LLLP History Added to 1,106 1 0.0% 0.0% 103 +214 23.99% Q4 2025 Feb 17, 2026
PNC FINANCIAL SERVICES GROUP, INC. History No change 1,461 1 0.0% 0.0% 102 0 0.0% Q4 2025 Feb 06, 2026
Global Retirement Partners, LLC History No change 1,000 1 0.0% 0.0% 104 0 0.0% Q4 2025 Feb 06, 2026
Avion Wealth History No change 1,333 1 0.0% 0.0% 105 0 0.0% Q4 2025 Jan 23, 2026
Physician Wealth Advisors, Inc. History No change 1,412 1 0.0% 0.0% 106 0 0.0% Q4 2025 Jan 29, 2026
Rialto Wealth Management, LLC History No change 1,313 1 0.0% 0.0% 107 0 0.0% Q4 2025 Jan 12, 2026
Caption Management, LLC History Closed out 0 0 0.02% -2,000,000 -100.0% Q3 2025 Nov 14, 2025
China Universal Asset Management Co., Ltd. History Closed out 0 0 0.01% -63,698 -100.0% Q3 2025 Nov 10, 2025
COMMONWEALTH EQUITY SERVICES, LLC History Closed out 0 0 0.0% -35,738 -100.0% Q3 2025 Oct 22, 2025
JPMORGAN CHASE & CO History Closed out 0 0 0.0% -30,037 -100.0% Q3 2025 Nov 26, 2025
Scientech Research LLC History Closed out 0 0 0.01% -24,884 -100.0% Q3 2025 Nov 14, 2025
IEQ CAPITAL, LLC History Closed out 0 0 0.0% -16,266 -100.0% Q3 2025 Nov 14, 2025
Mirae Asset Global Investments Co., Ltd. History Closed out 0 0 0.0% -14,049 -100.0% Q3 2025 Nov 03, 2025
ProShare Advisors LLC History Closed out 0 0 0.0% -12,946 -100.0% Q3 2025 Nov 06, 2025
NORTH STAR ASSET MANAGEMENT INC History Closed out 0 0 0.0% -11,500 -100.0% Q3 2025 Nov 10, 2025
SG Americas Securities, LLC History Closed out 0 0 0.0% -10,830 -100.0% Q3 2025 Oct 23, 2025
Steward Partners Investment Advisory, LLC History Reduced 500 0 0.0% -10,285 -95.36% Q4 2025 Feb 12, 2026
GF FUND MANAGEMENT CO. LTD. History Closed out 0 0 0.0% -7,818 -100.0% Q3 2025 Nov 07, 2025
Arax Advisory Partners History Reduced 41 0 0.0% -5,056 -99.2% Q4 2025 Feb 13, 2026
BNP PARIBAS FINANCIAL MARKETS History Reduced 11 0 0.0% -4,977 -99.78% Q4 2025 Feb 10, 2026
Advisory Services Network, LLC History Closed out 0 0 0.0% -3,242 -100.0% Q3 2025 Nov 18, 2025
Daiwa Securities Group Inc. History Closed out 0 0 0.0% -1,369 -100.0% Q3 2025 Nov 14, 2025
Caitong International Asset Management Co., Ltd History Reduced 294 0 0.0% -665 -69.34% Q4 2025 Mar 03, 2026
Federation des caisses Desjardins du Quebec History Closed out 0 0 -571 -100.0% Q3 2025 Nov 14, 2025
TFC Financial Management, Inc. History Closed out 0 0 -500 -100.0% Q3 2025 Oct 24, 2025
WELLS FARGO & COMPANY/MN History Reduced 1 0 -300 -99.67% Q4 2025 Feb 13, 2026
EverSource Wealth Advisors, LLC History Reduced 158 0 -297 -65.27% Q4 2025 Feb 06, 2026
Motiv8 Investments LLC History New 200 0 +200 New Q4 2025 Feb 13, 2026
OSAIC HOLDINGS, INC. History Reduced 642 0 -100 -13.48% Q4 2025 Feb 17, 2026
True Wealth Design, LLC History Reduced 49 0 -36 -42.35% Q4 2025 Jan 08, 2026
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO History Reduced 500 0 -14 -2.72% Q4 2025 Feb 10, 2026
IFP Advisors, Inc History Closed out 0 0 -1 -100.0% Q3 2025 Feb 06, 2026
COMERICA BANK History No change 122 0 0 0.0% Q4 2025 Jan 29, 2026
Larson Financial Group LLC History No change 100 0 0 0.0% Q4 2025 Feb 06, 2026
Rockefeller Capital Management L.P. History No change 335 0 0 0.0% Q4 2025 Mar 16, 2026
Covestor Ltd History No change 81 0 0 0.0% Q4 2025 Feb 06, 2026
Fortitude Family Office, LLC History No change 706 0 0 0.0% Q4 2025 Jan 15, 2026
SYNTAX RESEARCH, INC. History No change 142 0 0 0.0% Q4 2025 Feb 02, 2026