LEXICON PHARMACEUTICALS, INC. - LXRX

Detailed investor-level table based on 13F positions.

Shareholders (13F)

Quarter: Q1 2026 · Compare: Q4 2025
13D/13G major owners: Ownership tab.
Methodology: Market value and % of portfolio use SEC reported VALUE ($000). For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received. Details.
Rows: 0
Investor History Status Shares held Market value ($000) % of portfolio Previous % Rank Change in shares % change in shares Source Date reported
Artal Group S.A. History Added to 154,734,327 241,385 23.89% 21.91% 1 +18,553,846 13.62% Q1 2026 May 14, 2026
FMR LLC History Added to 45,056,338 70,287 0.0% 0.0% 2 +7,222,131 19.09% Q1 2026 May 15, 2026
Siren, L.L.C. History Added to 44,303,518 69,113 1.92% 1.34% 3 +5,384,615 13.84% Q1 2026 May 14, 2026
Sessa Capital IM, L.P. History Added to 17,912,961 27,944 0.51% 0.06% 4 +14,912,961 497.1% Q1 2026 May 15, 2026
VANGUARD CAPITAL MANAGEMENT LLC History New 9,519,167 14,849 0.0% 5 +9,519,167 New Q1 2026 May 15, 2026
Point72 Asset Management, L.P. History Added to 7,814,606 12,190 0.02% 0.0% 6 +7,530,581 2651.38% Q1 2026 May 15, 2026
VANGUARD GROUP INC History No change 9,606,549 11,047 0.0% 0.0% 7 0 0.0% Q4 2025 Jan 29, 2026
MILLENNIUM MANAGEMENT LLC History Added to 4,944,731 7,713 0.0% 0.0% 8 +122,998 2.55% Q1 2026 May 15, 2026
BlackRock, Inc. History Added to 3,322,219 5,182 0.0% 0.0% 9 +129,771 4.06% Q1 2026 May 13, 2026
JANE STREET GROUP, LLC History Added to 3,238,938 5,052 0.0% 0.0% 10 +1,410,534 77.15% Q1 2026 May 12, 2026
GEODE CAPITAL MANAGEMENT, LLC History Added to 3,169,111 4,945 0.0% 0.0% 11 +669,089 26.76% Q1 2026 May 15, 2026
SUSQUEHANNA INTERNATIONAL GROUP, LLP History Added to 2,766,264 4,315 0.0% 0.0% 12 +1,223,022 79.25% Q1 2026 May 15, 2026
UBS Group AG History Reduced 2,483,182 3,873 0.0% 0.0% 13 -524,055 -17.43% Q1 2026 May 05, 2026
MARSHALL WACE, LLP History Added to 2,376,304 3,707 0.0% 0.0% 14 +1,113,937 88.24% Q1 2026 May 14, 2026
CIBC Bancorp USA Inc. History New 1,800,000 2,808 0.0% 15 +1,800,000 New Q1 2026 May 12, 2026
CITADEL ADVISORS LLC History Reduced 1,687,301 2,632 0.0% 0.0% 16 -581,774 -25.64% Q1 2026 May 15, 2026
RENAISSANCE TECHNOLOGIES LLC History Added to 1,600,500 2,496 0.0% 0.0% 17 +1,337,246 507.97% Q1 2026 May 14, 2026
CIBC Private Wealth Group LLC History No change 1,950,000 2,242 0.0% 0.0% 18 0 0.0% Q4 2025 Feb 12, 2026
VANGUARD FIDUCIARY TRUST CO History New 1,332,284 2,078 0.0% 19 +1,332,284 New Q1 2026 May 08, 2026
CHARLES SCHWAB INVESTMENT MANAGEMENT INC History Added to 1,311,298 2,045 0.0% 0.0% 20 +256,175 24.28% Q1 2026 May 15, 2026
TWO SIGMA INVESTMENTS, LP History Added to 1,199,632 1,871 0.0% 0.0% 21 +562,324 88.23% Q1 2026 May 15, 2026
GOLDMAN SACHS GROUP INC History Added to 1,070,517 1,670 0.0% 0.0% 22 +149,313 16.21% Q1 2026 May 15, 2026
STATE STREET CORP History Added to 964,038 1,503 0.0% 0.0% 23 +79,300 8.96% Q1 2026 May 15, 2026
GSA CAPITAL PARTNERS LLP History Reduced 930,089 1,451 0.09% 0.1% 24 -66,146 -6.64% Q1 2026 May 08, 2026
Ishara Investments LP History Added to 902,000 1,407 1.33% 1.16% 25 +22,000 2.5% Q1 2026 May 15, 2026
Hennion & Walsh Asset Management, Inc. History Reduced 848,138 1,323 0.04% 0.04% 26 -53,084 -5.89% Q1 2026 May 13, 2026
MACKENZIE FINANCIAL CORP History New 772,677 1,205 0.0% 27 +772,677 New Q1 2026 May 13, 2026
ADAR1 Capital Management, LLC History New 750,000 1,170 0.07% 28 +750,000 New Q1 2026 May 15, 2026
VANGUARD PORTFOLIO MANAGEMENT LLC History New 546,600 852 0.0% 29 +546,600 New Q1 2026 May 08, 2026
BANK OF AMERICA CORP /DE/ History Added to 526,103 820 0.0% 0.0% 30 +424,006 415.3% Q1 2026 May 15, 2026
Invesco Ltd. History Reduced 512,426 799 0.0% 0.0% 31 -82,457 -13.86% Q1 2026 May 12, 2026
Compagnie Lombard Odier SCmA History Added to 510,000 795 0.01% 0.01% 32 +100,000 24.39% Q1 2026 Apr 15, 2026
NORTHERN TRUST CORP History Added to 494,666 771 0.0% 0.0% 33 +82,502 20.02% Q1 2026 May 14, 2026
ACADIAN ASSET MANAGEMENT LLC History Reduced 445,288 693 0.0% 0.0% 34 -194,842 -30.44% Q1 2026 May 13, 2026
TANG CAPITAL MANAGEMENT LLC History New 399,700 623 0.03% 35 +399,700 New Q1 2026 May 15, 2026
XTX Topco Ltd History Added to 314,614 490 0.01% 0.0% 36 +218,524 227.42% Q1 2026 May 15, 2026
MORGAN STANLEY History Added to 219,862 342 0.0% 0.0% 37 +26,827 13.9% Q1 2026 May 15, 2026
Catalyst Funds Management Pty Ltd History Added to 207,900 324 0.05% 0.01% 38 +167,600 415.88% Q1 2026 May 11, 2026
Headlands Technologies LLC History Added to 191,322 298 0.03% 0.01% 39 +55,209 40.56% Q1 2026 May 13, 2026
GROUP ONE TRADING LLC History Reduced 185,006 288 0.0% 0.0% 40 -39,302 -17.52% Q1 2026 May 13, 2026
CITIGROUP INC History Added to 166,398 259 0.0% 0.0% 41 +74,728 81.52% Q1 2026 May 11, 2026
Ikarian Capital, LLC History No change 164,674 256 0.02% 0.01% 42 0 0.0% Q1 2026 May 15, 2026
Brevan Howard Capital Management LP History New 160,499 250 0.0% 43 +160,499 New Q1 2026 May 15, 2026
SCOTIA CAPITAL INC. History New 159,831 249 0.0% 44 +159,831 New Q1 2026 May 13, 2026
Jain Global LLC History New 154,800 241 0.0% 45 +154,800 New Q1 2026 May 15, 2026
Hudson Bay Capital Management LP History Added to 152,616 238 0.0% 0.0% 46 +52,084 51.81% Q1 2026 May 13, 2026
TWO SIGMA ADVISERS, LP History No change 180,977 208 0.0% 0.0% 47 0 0.0% Q4 2025 Feb 17, 2026
JACOBS LEVY EQUITY MANAGEMENT, INC History New 130,020 202 0.0% 48 +130,020 New Q1 2026 May 15, 2026
Bridgewater Advisors Inc. History New 82,209 200 0.01% 49 +82,209 New Q1 2026 May 14, 2026
HRT FINANCIAL LP History Added to 122,780 191 0.0% 0.0% 50 +5,231 4.45% Q1 2026 May 14, 2026
Quadrature Capital Ltd History Added to 110,379 172 0.0% 0.0% 52 +91,965 499.43% Q1 2026 May 15, 2026
Cerity Partners LLC History Reduced 110,458 172 0.0% 0.0% 51 -34,486 -23.79% Q1 2026 May 15, 2026
Quarry LP History Added to 110,000 171 0.03% 0.02% 53 +22,000 25.0% Q1 2026 May 15, 2026
Man Group plc History New 108,806 169 0.0% 54 +108,806 New Q1 2026 May 15, 2026
OMERS ADMINISTRATION Corp History Reduced 106,800 166 0.0% 0.0% 55 -167,000 -60.99% Q1 2026 May 15, 2026
BARCLAYS PLC History Reduced 105,487 164 0.0% 0.0% 56 -89,256 -45.83% Q1 2026 May 14, 2026
AQR CAPITAL MANAGEMENT LLC History Reduced 96,234 150 0.0% 0.0% 57 -48,566 -33.54% Q1 2026 May 15, 2026
Vanguard Global Advisers, LLC History New 93,641 146 0.0% 58 +93,641 New Q1 2026 May 08, 2026
Schonfeld Strategic Advisors LLC History Added to 75,110 117 0.0% 0.0% 59 +62,002 473.01% Q1 2026 May 15, 2026
BANK OF NOVA SCOTIA History New 73,707 114 0.0% 60 +73,707 New Q1 2026 May 14, 2026
BANK OF MONTREAL /CAN/ History No change 70,000 109 0.0% 0.0% 61 0 0.0% Q1 2026 May 13, 2026
LPL Financial LLC History Reduced 69,783 108 0.0% 0.0% 62 -17,274 -19.84% Q1 2026 May 06, 2026
Jefferies Financial Group Inc. History Reduced 68,734 107 0.0% 0.0% 63 -23,796 -25.72% Q1 2026 May 07, 2026
Diametric Capital, LP History New 67,841 105 0.03% 65 +67,841 New Q1 2026 May 15, 2026
R Squared Ltd History Added to 67,526 105 0.06% 0.02% 64 +20,947 44.97% Q1 2026 Apr 29, 2026
Straight Path Wealth Management History No change 62,666 97 0.03% 0.02% 66 0 0.0% Q1 2026 Apr 22, 2026
Vanguard Personalized Indexing Management, LLC History Reduced 54,965 85 0.0% 0.0% 67 -11,602 -17.43% Q1 2026 May 14, 2026
Fortis Group Advisors, LLC History No change 50,000 80 0.01% 0.01% 68 0 0.0% Q1 2026 May 08, 2026
EntryPoint Capital, LLC History Added to 48,498 75 0.02% 0.01% 69 +14,880 44.26% Q1 2026 May 14, 2026
BOOTHBAY FUND MANAGEMENT, LLC History No change 44,315 69 0.0% 0.0% 70 0 0.0% Q1 2026 May 15, 2026
WEDBUSH SECURITIES INC History No change 40,850 64 0.0% 0.0% 71 0 0.0% Q1 2026 Apr 21, 2026
Jump Financial, LLC History New 40,246 62 0.0% 72 +40,246 New Q1 2026 May 14, 2026
CIBC Asset Management Inc History No change 39,520 61 0.0% 0.0% 73 0 0.0% Q1 2026 May 12, 2026
ExodusPoint Capital Management, LP History Reduced 37,430 58 0.0% 0.0% 74 -231,003 -86.06% Q1 2026 May 14, 2026
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO History No change 35,714 55 0.01% 0.01% 75 0 0.0% Q1 2026 May 07, 2026
Graham Capital Management, L.P. History Reduced 34,027 53 0.0% 0.0% 76 -75,873 -69.04% Q1 2026 May 15, 2026
PRUDENTIAL FINANCIAL INC History No change 33,800 52 0.0% 0.0% 77 0 0.0% Q1 2026 May 13, 2026
Pathstone Holdings, LLC History Reduced 29,774 46 0.0% 0.0% 80 -195 -0.65% Q1 2026 May 11, 2026
Leonteq Securities AG History No change 30,000 46 0.0% 0.0% 78 0 0.0% Q1 2026 Apr 27, 2026
KWB Wealth History No change 40,640 46 0.0% 0.0% 79 0 0.0% Q1 2026 Apr 08, 2026
PINNACLE ASSOCIATES LTD History No change 29,015 45 0.0% 0.0% 81 0 0.0% Q1 2026 Apr 21, 2026
Bank of New York Mellon Corp History Added to 27,459 42 0.0% 0.0% 82 +8,335 43.58% Q1 2026 May 05, 2026
SECURITY NATIONAL BANK OF SIOUX CITY IOWA /IA/ History No change 26,650 41 0.02% 0.02% 83 0 0.0% Q1 2026 May 15, 2026
WINTON GROUP Ltd History New 25,500 39 0.0% 84 +25,500 New Q1 2026 May 12, 2026
LMR Partners LLP History New 23,305 36 0.0% 86 +23,305 New Q1 2026 May 15, 2026
OPPENHEIMER & CO INC History No change 23,500 36 0.0% 0.0% 85 0 0.0% Q1 2026 Apr 23, 2026
VICTORY CAPITAL MANAGEMENT INC History Added to 22,679 35 0.0% 0.0% 87 +1,488 7.02% Q1 2026 May 15, 2026
Cambridge Investment Research Advisors, Inc. History No change 21,505 34 0.0% 0.0% 88 0 0.0% Q1 2026 Apr 30, 2026
AXQ CAPITAL, LP History New 20,150 31 0.0% 92 +20,150 New Q1 2026 May 13, 2026
TIAA-CREF INDIVIDUAL & INSTITUTIONAL SERVICES, LLC History New 20,000 31 0.0% 90 +20,000 New Q1 2026 May 12, 2026
DIKER MANAGEMENT LLC History New 20,000 31 0.03% 91 +20,000 New Q1 2026 May 15, 2026
Invera Wealth Advisors, LLC History No change 20,000 31 0.02% 0.01% 89 0 0.0% Q1 2026 Apr 22, 2026
CREDIT AGRICOLE S A History No change 18,975 29 0.0% 0.0% 93 0 0.0% Q1 2026 May 15, 2026
Quantessence Capital LLC History New 18,581 28 0.14% 94 +18,581 New Q1 2026 May 15, 2026
CTC Alternative Strategies, Ltd. History New 17,544 27 0.06% 96 +17,544 New Q1 2026 May 21, 2026
BNP PARIBAS FINANCIAL MARKETS History Added to 17,550 27 0.0% 95 +17,539 159445.45% Q1 2026 May 12, 2026
PRELUDE CAPITAL MANAGEMENT, LLC History New 17,173 26 0.0% 97 +17,173 New Q1 2026 May 15, 2026
CAPTRUST FINANCIAL ADVISORS History Added to 15,450 24 0.0% 0.0% 98 +3,715 31.66% Q1 2026 May 14, 2026
HBK Sorce Advisory LLC History No change 11,786 23 0.0% 0.0% 99 0 0.0% Q1 2026 May 11, 2026
TRUIST FINANCIAL CORP History No change 14,000 21 0.0% 0.0% 100 0 0.0% Q1 2026 Apr 27, 2026
Callan Family Office, LLC History No change 14,090 21 0.0% 0.0% 101 0 0.0% Q1 2026 May 13, 2026
Cetera Investment Advisers History Reduced 12,633 19 0.0% 0.0% 103 -1,555 -10.96% Q1 2026 May 13, 2026
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC History Reduced 12,388 19 0.0% 0.0% 102 -1,132 -8.37% Q1 2026 Apr 08, 2026
FWG Holdings, LLC History New 11,350 18 0.01% 105 +11,350 New Q1 2026 Apr 13, 2026
Chemistry Wealth Management LLC History No change 12,000 18 0.0% 0.0% 104 0 0.0% Q1 2026 Apr 09, 2026
Mariner, LLC History New 11,072 17 0.0% 107 +11,072 New Q1 2026 May 13, 2026
Perennial Investment Advisors, LLC History No change 10,990 17 0.0% 0.0% 106 0 0.0% Q1 2026 May 15, 2026
State of Wyoming History Reduced 10,779 16 0.0% 0.01% 109 -49,792 -82.2% Q1 2026 May 13, 2026
CWM, LLC History Reduced 10,402 16 0.0% 0.0% 108 -2,777 -21.07% Q1 2026 May 14, 2026
Talisman Wealth Advisors LLC History New 10,000 15 0.01% 112 +10,000 New Q1 2026 May 15, 2026
NBT BANK N A /NY History No change 10,000 15 0.0% 0.0% 110 0 0.0% Q1 2026 Apr 28, 2026
Berger Financial Group, Inc History No change 10,000 15 0.0% 0.0% 111 0 0.0% Q1 2026 Apr 28, 2026
WELLS FARGO & COMPANY/MN History Added to 7,760 12 0.0% 113 +7,759 775900.0% Q1 2026 May 11, 2026
SBI Securities Co., Ltd. History Added to 4,081 6 0.0% 0.0% 114 +1,063 35.22% Q1 2026 Apr 27, 2026
Advisory Services Network, LLC History New 3,242 5 0.0% 115 +3,242 New Q1 2026 May 15, 2026
NISA INVESTMENT ADVISORS, LLC History No change 2,592 4 0.0% 0.0% 116 0 0.0% Q1 2026 Apr 30, 2026
ROYAL BANK OF CANADA History Reduced 1,551 2 0.0% 0.0% 118 -5,217 -77.08% Q1 2026 May 15, 2026
PNC FINANCIAL SERVICES GROUP, INC. History No change 1,461 2 0.0% 0.0% 117 0 0.0% Q1 2026 May 08, 2026
Avion Wealth History No change 1,333 2 0.0% 0.0% 119 0 0.0% Q1 2026 May 01, 2026
Physician Wealth Advisors, Inc. History No change 1,412 2 0.0% 0.0% 120 0 0.0% Q1 2026 Apr 24, 2026
Rialto Wealth Management, LLC History No change 1,313 2 0.0% 0.0% 121 0 0.0% Q1 2026 May 14, 2026
Cassaday & Co Wealth Management LLC History New 1,000 1 0.0% 125 +1,000 New Q1 2026 May 07, 2026
OSAIC HOLDINGS, INC. History Added to 663 1 0.0% 122 +21 3.27% Q1 2026 May 15, 2026
Global Retirement Partners, LLC History No change 1,000 1 0.0% 0.0% 123 0 0.0% Q4 2025 Feb 06, 2026
Fortitude Family Office, LLC History No change 706 1 0.0% 124 0 0.0% Q1 2026 Apr 15, 2026
Lighthouse Investment Partners, LLC History Closed out 0 0 0.0% -126,600 -100.0% Q1 2026 May 14, 2026
Monaco Asset Management SAM History Closed out 0 0 0.02% -117,188 -100.0% Q1 2026 May 11, 2026
TWO SIGMA SECURITIES, LLC History Closed out 0 0 0.02% -114,632 -100.0% Q1 2026 May 15, 2026
CAXTON ASSOCIATES LLP History Closed out 0 0 0.0% -71,027 -100.0% Q1 2026 May 14, 2026
Squarepoint Ops LLC History Closed out 0 0 0.0% -60,472 -100.0% Q1 2026 May 15, 2026
Optiver Holding B.V. History Closed out 0 0 0.0% -52,595 -100.0% Q1 2026 Jun 02, 2026
Virtu Financial LLC History Closed out 0 0 0.0% -36,468 -100.0% Q1 2026 May 14, 2026
Vermillion & White Wealth Management Group, LLC History Closed out 0 0 0.02% -32,000 -100.0% Q1 2026 May 15, 2026
Tower Research Capital LLC (TRC) History Closed out 0 0 0.0% -29,093 -100.0% Q1 2026 May 15, 2026
TIAA TRUST, NATIONAL ASSOCIATION History Closed out 0 0 0.0% -20,000 -100.0% Q1 2026 May 12, 2026
StoneX Group Inc. History Closed out 0 0 0.0% -16,234 -100.0% Q1 2026 May 14, 2026
SIMPLEX TRADING, LLC History Closed out 0 0 0.0% -14,758 -100.0% Q1 2026 May 14, 2026
LAZARD ASSET MANAGEMENT LLC History Closed out 0 0 0.0% -14,090 -100.0% Q1 2026 May 15, 2026
Golden State Wealth Management, LLC History Closed out 0 0 0.0% -3,700 -100.0% Q1 2026 Apr 28, 2026
Farther Finance Advisors, LLC History Reduced 255 0 0.0% -2,500 -90.74% Q1 2026 Apr 07, 2026
JONES FINANCIAL COMPANIES LLLP History Reduced 356 0 0.0% -750 -67.81% Q1 2026 May 15, 2026
Parallel Advisors, LLC History New 247 0 +247 New Q1 2026 Jun 02, 2026
EverSource Wealth Advisors, LLC History Reduced 48 0 -110 -69.62% Q1 2026 May 15, 2026
Caitong International Asset Management Co., Ltd History Added to 353 0 +59 20.07% Q1 2026 May 11, 2026
True Wealth Design, LLC History Reduced 2 0 -47 -95.92% Q1 2026 Apr 13, 2026
HM PAYSON & CO History New 37 0 +37 New Q1 2026 Apr 13, 2026
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO History Added to 503 0 +3 0.6% Q1 2026 May 07, 2026
COMERICA BANK History No change 122 0 0 0.0% Q4 2025 Jan 29, 2026
Arax Advisory Partners History No change 41 0 0 0.0% Q1 2026 May 13, 2026
Steward Partners Investment Advisory, LLC History No change 500 0 0 0.0% Q1 2026 May 08, 2026
Larson Financial Group LLC History No change 100 0 0 0.0% Q1 2026 May 15, 2026
Rockefeller Capital Management L.P. History No change 335 0 0 0.0% Q1 2026 May 14, 2026
Covestor Ltd History No change 81 0 0 0.0% Q1 2026 May 05, 2026
SYNTAX RESEARCH, INC. History No change 142 0 0 0.0% Q1 2026 Apr 24, 2026
Motiv8 Investments LLC History No change 200 0 0 0.0% Q4 2025 Feb 13, 2026