Spyre Therapeutics, Inc. - SYRE
Insiders (Form 4) · last 180 days · showing up to 200 transactions
· Form 144 is shown in the SEC filings tab
· Updating…
Visible: 0
Transaction codes:
P = Open-market purchase ·
S = Open-market sale ·
A = Grant/award ·
M = Exercise/conversion of derivative ·
G = Gift ·
F = Tax withholding ·
J = Other ·
A/D:
A = Acquired (buy/receive) ·
D = Disposed (sell/give)
| Filed | Owner | Title | Code | A/D | Shares | Price | Value | Shares after | SEC |
|---|---|---|---|---|---|---|---|---|---|
| Oct 02, 2026 | See Remarks | M | D | 28,933.0 | 0.0 | 0.0 | 482,478.0 | View | |
| Oct 02, 2026 | See Remarks | S | D | 2,600.0 | 93.46 | 242,996.0 | 2,845.0 | View | |
| Oct 02, 2026 | See Remarks | S | D | 2,100.0 | 92.7 | 194,670.0 | 5,445.0 | View | |
| Oct 02, 2026 | See Remarks | S | D | 7,228.0 | 91.35 | 660,277.8 | 7,545.0 | View | |
| Oct 02, 2026 | See Remarks | S | D | 16,605.0 | 90.35 | 1,500,261.75 | 14,773.0 | View | |
| Oct 02, 2026 | See Remarks | S | D | 400.0 | 89.24 | 35,696.0 | 31,378.0 | View | |
| Oct 02, 2026 | See Remarks | M | A | 28,933.0 | 14.5 | 419,528.5 | 31,778.0 | View | |
| Oct 02, 2026 | Chief Executive Officer | S | D | 100.0 | 93.91 | 9,391.0 | 537,540.0 | View | |
| Oct 02, 2026 | Chief Executive Officer | S | D | 4,990.0 | 93.37 | 465,916.3 | 537,640.0 | View | |
| Oct 02, 2026 | Chief Executive Officer | S | D | 3,989.0 | 92.31 | 368,224.59 | 542,630.0 | View | |
| Oct 02, 2026 | Chief Executive Officer | S | D | 2,638.0 | 91.49 | 241,350.62 | 546,619.0 | View | |
| Oct 02, 2026 | Chief Executive Officer | S | D | 2,683.0 | 90.1 | 241,738.3 | 549,257.0 | View | |
| Oct 02, 2026 | Chief Executive Officer | S | D | 600.0 | 89.14 | 53,484.0 | 551,940.0 | View | |
| Oct 02, 2026 | Chief Financial Officer | M | D | 7,500.0 | 0.0 | 0.0 | 312,357.0 | View | |
| Oct 02, 2026 | Chief Financial Officer | M | D | 17,500.0 | 0.0 | 0.0 | 319,857.0 | View | |
| Oct 02, 2026 | Chief Financial Officer | S | D | 229.0 | 93.57 | 21,427.53 | 79,762.0 | View | |
| Oct 02, 2026 | Chief Financial Officer | S | D | 3,071.0 | 92.95 | 285,449.45 | 79,991.0 | View | |
| Oct 02, 2026 | Chief Financial Officer | S | D | 2,100.0 | 91.92 | 193,032.0 | 83,062.0 | View | |
| Oct 02, 2026 | Chief Financial Officer | S | D | 1,500.0 | 90.27 | 135,405.0 | 85,162.0 | View | |
| Oct 02, 2026 | Chief Financial Officer | S | D | 600.0 | 89.07 | 53,442.0 | 86,662.0 | View | |
| Oct 02, 2026 | Chief Financial Officer | M | A | 7,500.0 | 14.5 | 108,750.0 | 87,262.0 | View | |
| Oct 02, 2026 | Chief Financial Officer | S | D | 17,500.0 | 89.89 | 1,573,075.0 | 79,762.0 | View | |
| Oct 02, 2026 | Chief Financial Officer | M | A | 17,500.0 | 14.5 | 253,750.0 | 97,262.0 | View | |
| Sep 03, 2026 | See Remarks | M | D | 400.0 | 0.0 | 0.0 | 511,411.0 | View | |
| Sep 03, 2026 | See Remarks | M | D | 27,999.0 | 0.0 | 0.0 | 511,811.0 | View | |
| Sep 03, 2026 | See Remarks | S | D | 400.0 | 90.0 | 36,000.0 | 2,845.0 | View | |
| Sep 03, 2026 | See Remarks | M | A | 400.0 | 14.5 | 5,800.0 | 3,245.0 | View | |
| Sep 03, 2026 | See Remarks | S | D | 400.0 | 89.38 | 35,752.0 | 2,845.0 | View | |
| Sep 03, 2026 | See Remarks | S | D | 6,206.0 | 88.17 | 547,183.02 | 3,245.0 | View | |
| Sep 03, 2026 | See Remarks | S | D | 16,548.0 | 87.2 | 1,442,985.6 | 9,451.0 | View | |
| Sep 03, 2026 | See Remarks | S | D | 4,845.0 | 86.4 | 418,608.0 | 25,999.0 | View | |
| Sep 03, 2026 | See Remarks | M | A | 27,999.0 | 14.5 | 405,985.5 | 30,844.0 | View | |
| Sep 03, 2026 | Chief Financial Officer | M | D | 7,500.0 | 0.0 | 0.0 | 337,357.0 | View | |
| Sep 03, 2026 | Chief Financial Officer | S | D | 18,232.0 | 89.35 | 1,629,029.2 | 79,762.0 | View | |
| Sep 03, 2026 | Chief Financial Officer | S | D | 200.0 | 89.04 | 17,808.0 | 97,994.0 | View | |
| Sep 03, 2026 | Chief Financial Officer | S | D | 2,016.0 | 88.03 | 177,468.48 | 98,194.0 | View | |
| Sep 03, 2026 | Chief Financial Officer | S | D | 4,384.0 | 87.11 | 381,890.24 | 100,210.0 | View | |
| Sep 03, 2026 | Chief Financial Officer | S | D | 900.0 | 86.25 | 77,625.0 | 104,594.0 | View | |
| Sep 03, 2026 | Chief Financial Officer | M | A | 7,500.0 | 14.5 | 108,750.0 | 105,494.0 | View | |
| Sep 03, 2026 | Chief Executive Officer | S | D | 400.0 | 89.07 | 35,628.0 | 552,540.0 | View | |
| Sep 03, 2026 | Chief Executive Officer | S | D | 3,700.0 | 88.06 | 325,822.0 | 552,940.0 | View | |
| Sep 03, 2026 | Chief Executive Officer | S | D | 8,400.0 | 87.15 | 732,060.0 | 556,640.0 | View | |
| Sep 03, 2026 | Chief Executive Officer | S | D | 2,500.0 | 86.36 | 215,900.0 | 565,040.0 | View | |
| Aug 10, 2026 | — | M | D | 5,000.0 | 0.0 | 0.0 | 45,000.0 | View | |
| Aug 10, 2026 | — | S | D | 10,000.0 | 104.68 | 1,046,800.0 | 9,360.0 | View | |
| Aug 10, 2026 | — | S | D | 8,000.0 | 104.38 | 835,040.0 | 19,360.0 | View | |
| Aug 10, 2026 | — | S | D | 5,000.0 | 104.47 | 522,350.0 | 0.0 | View | |
| Aug 10, 2026 | — | M | A | 5,000.0 | 10.39 | 51,950.0 | 5,000.0 | View | |
| Aug 05, 2026 | Chief Financial Officer | M | D | 7,500.0 | 0.0 | 0.0 | 344,857.0 | View | |
| Aug 05, 2026 | Chief Financial Officer | S | D | 100.0 | 97.1 | 9,710.0 | 97,994.0 | View | |
| Aug 05, 2026 | Chief Financial Officer | S | D | 2,300.0 | 96.3 | 221,490.0 | 98,094.0 | View | |
| Aug 05, 2026 | Chief Financial Officer | S | D | 5,100.0 | 95.21 | 485,571.0 | 100,394.0 | View | |
| Aug 05, 2026 | Chief Financial Officer | M | A | 7,500.0 | 14.5 | 108,750.0 | 105,494.0 | View | |
| Aug 05, 2026 | Chief Executive Officer | S | D | 16.0 | 97.46 | 1,559.36 | 567,540.0 | View | |
| Aug 05, 2026 | Chief Executive Officer | S | D | 1,392.0 | 96.82 | 134,773.44 | 567,556.0 | View | |
| Aug 05, 2026 | Chief Executive Officer | S | D | 5,635.0 | 95.93 | 540,565.55 | 568,948.0 | View | |
| Aug 05, 2026 | Chief Executive Officer | S | D | 7,157.0 | 95.1 | 680,630.7 | 574,583.0 | View | |
| Aug 05, 2026 | Chief Executive Officer | S | D | 800.0 | 93.97 | 75,176.0 | 581,740.0 | View | |
| Jul 02, 2026 | Chief Financial Officer | M | D | 7,500.0 | 0.0 | 0.0 | 352,357.0 | View | |
| Jul 02, 2026 | Chief Financial Officer | S | D | 1,725.0 | 88.37 | 152,438.25 | 97,994.0 | View | |
| Jul 02, 2026 | Chief Financial Officer | S | D | 5,775.0 | 87.55 | 505,601.25 | 99,719.0 | View | |
| Jul 02, 2026 | Chief Financial Officer | M | A | 7,500.0 | 14.5 | 108,750.0 | 105,494.0 | View | |
| Jul 02, 2026 | Chief Medical Officer | M | D | 8,334.0 | 0.0 | 0.0 | 305,000.0 | View | |
| Jul 02, 2026 | Chief Medical Officer | S | D | 1,834.0 | 88.34 | 162,015.56 | 0.0 | View | |
| Jul 02, 2026 | Chief Medical Officer | S | D | 6,500.0 | 87.52 | 568,880.0 | 1,834.0 | View | |
| Jul 02, 2026 | Chief Medical Officer | M | A | 8,334.0 | 27.46 | 228,851.64 | 8,334.0 | View | |
| Jul 02, 2026 | Chief Executive Officer | S | D | 590.0 | 88.91 | 52,456.9 | 582,540.0 | View | |
| Jul 02, 2026 | Chief Executive Officer | S | D | 4,234.0 | 88.12 | 373,100.08 | 583,130.0 | View | |
| Jul 02, 2026 | Chief Executive Officer | S | D | 10,176.0 | 87.44 | 889,789.44 | 587,364.0 | View | |
| Jun 26, 2026 | Chief Financial Officer | M | D | 15,000.0 | 0.0 | 0.0 | 359,857.0 | View | |
| Jun 26, 2026 | Chief Financial Officer | S | D | 10,000.0 | 87.14 | 871,400.0 | 97,994.0 | View | |
| Jun 26, 2026 | Chief Financial Officer | S | D | 5,000.0 | 87.12 | 435,600.0 | 107,994.0 | View | |
| Jun 26, 2026 | Chief Financial Officer | M | A | 15,000.0 | 14.5 | 217,500.0 | 112,994.0 | View | |
| Jun 23, 2026 | — | C | D | 16,667.0 | 0.0 | 0.0 | 0.0 | View | |
| Jun 23, 2026 | — | S | D | 4,684,781.0 | 85.31 | 399,658,667.11 | 0.0 | View | |
| Jun 23, 2026 | — | C | A | 666,680.0 | — | — | 4,684,781.0 | View | |
| Jun 23, 2026 | — | S | D | 20,000.0 | 100.0 | 2,000,000.0 | 68,606.0 | View | |
| Jun 03, 2026 | Chief Medical Officer | M | D | 8,333.0 | 0.0 | 0.0 | 313,334.0 | View | |
| Jun 03, 2026 | Chief Medical Officer | S | D | 8,333.0 | 75.0 | 624,975.0 | 0.0 | View | |
| Jun 03, 2026 | Chief Medical Officer | M | A | 8,333.0 | 27.46 | 228,824.18 | 8,333.0 | View | |
| Jun 03, 2026 | Chief Executive Officer | S | D | 3,294.0 | 71.38 | 235,125.72 | 597,540.0 | View | |
| Jun 03, 2026 | Chief Executive Officer | S | D | 8,149.0 | 70.5 | 574,504.5 | 600,834.0 | View | |
| Jun 03, 2026 | Chief Executive Officer | S | D | 3,557.0 | 69.4 | 246,855.8 | 608,983.0 | View | |
| Jun 03, 2026 | Chief Financial Officer | M | D | 7,500.0 | 0.0 | 0.0 | 374,857.0 | View | |
| Jun 03, 2026 | Chief Financial Officer | S | D | 3,100.0 | 72.06 | 223,386.0 | 97,994.0 | View | |
| Jun 03, 2026 | Chief Financial Officer | S | D | 2,599.0 | 70.77 | 183,931.23 | 101,094.0 | View | |
| Jun 03, 2026 | Chief Financial Officer | S | D | 1,801.0 | 69.75 | 125,619.75 | 103,693.0 | View | |
| Jun 03, 2026 | Chief Financial Officer | M | A | 7,500.0 | 14.5 | 108,750.0 | 105,494.0 | View | |
| May 29, 2026 | — | A | A | 8,026.0 | 0.0 | 0.0 | 8,026.0 | View | |
| May 29, 2026 | — | A | A | 8,026.0 | 0.0 | 0.0 | 8,026.0 | View | |
| May 29, 2026 | — | A | A | 8,026.0 | 0.0 | 0.0 | 8,026.0 | View | |
| May 29, 2026 | — | A | A | 8,026.0 | 0.0 | 0.0 | 8,026.0 | View | |
| May 29, 2026 | — | A | A | 8,026.0 | 0.0 | 0.0 | 8,026.0 | View | |
| May 29, 2026 | — | A | A | 8,026.0 | 0.0 | 0.0 | 8,026.0 | View | |
| May 08, 2026 | — | S | D | 19,269.0 | 75.35 | 1,451,919.15 | 88,606.0 | View | |
| May 08, 2026 | — | S | D | 24,814.0 | 74.76 | 1,855,094.64 | 107,875.0 | View | |
| May 08, 2026 | — | S | D | 33,513.0 | 73.72 | 2,470,578.36 | 132,689.0 | View | |
| May 08, 2026 | — | S | D | 2,404.0 | 72.57 | 174,458.28 | 166,202.0 | View | |
| May 01, 2026 | Chief Medical Officer | M | D | 78,333.0 | 0.0 | 0.0 | 321,667.0 | View | |
| May 01, 2026 | Chief Medical Officer | S | D | 400.0 | 75.37 | 30,148.0 | 0.0 | View | |
| May 01, 2026 | Chief Medical Officer | S | D | 5,059.0 | 74.6 | 377,401.4 | 400.0 | View | |
| May 01, 2026 | Chief Medical Officer | S | D | 10,358.0 | 73.74 | 763,798.92 | 5,459.0 | View | |
| May 01, 2026 | Chief Medical Officer | S | D | 12,777.0 | 72.94 | 931,954.38 | 15,817.0 | View | |
| May 01, 2026 | Chief Medical Officer | S | D | 8,777.0 | 71.56 | 628,082.12 | 28,594.0 | View | |
| May 01, 2026 | Chief Medical Officer | S | D | 19,656.0 | 70.61 | 1,387,910.16 | 37,371.0 | View | |
| May 01, 2026 | Chief Medical Officer | S | D | 21,306.0 | 69.53 | 1,481,406.18 | 57,027.0 | View | |
| May 01, 2026 | Chief Medical Officer | M | A | 78,333.0 | 27.46 | 2,151,024.18 | 78,333.0 | View | |
| May 01, 2026 | Chief Financial Officer | M | D | 12,500.0 | 0.0 | 0.0 | 382,357.0 | View | |
| May 01, 2026 | Chief Financial Officer | S | D | 12,500.0 | 71.37 | 892,125.0 | 97,994.0 | View | |
| May 01, 2026 | Chief Financial Officer | M | A | 12,500.0 | 14.5 | 181,250.0 | 110,494.0 | View | |
| May 01, 2026 | Chief Executive Officer | S | D | 300.0 | 74.96 | 22,488.0 | 612,540.0 | View | |
| May 01, 2026 | Chief Executive Officer | S | D | 1,700.0 | 74.23 | 126,191.0 | 612,840.0 | View | |
| May 01, 2026 | Chief Executive Officer | S | D | 3,100.0 | 73.14 | 226,734.0 | 614,540.0 | View | |
| May 01, 2026 | Chief Executive Officer | S | D | 1,000.0 | 71.76 | 71,760.0 | 617,640.0 | View | |
| May 01, 2026 | Chief Executive Officer | S | D | 3,600.0 | 70.77 | 254,772.0 | 618,640.0 | View | |
| May 01, 2026 | Chief Executive Officer | S | D | 5,300.0 | 69.54 | 368,562.0 | 622,240.0 | View |