Tyra Biosciences, Inc. - TYRA

Detailed investor-level table based on 13F positions.
Early Q1 2026 data: only 8 institutional holders reported so far. The full shareholder list will grow as more funds file with the SEC.

Shareholders (13F)

Quarter: Q4 2025 · Compare: Q3 2025
13D/13G major owners: Ownership tab.
Methodology: Market value and % of portfolio use SEC reported VALUE ($000). For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received. Details.
Rows: 0
Investor History Status Shares held Market value ($000) % of portfolio Previous % Rank Change in shares % change in shares Source Date reported
RA CAPITAL MANAGEMENT, L.P. History No change 12,198,625 320,701 3.29% 2.1% 1 0 0.0% Q4 2025 Feb 17, 2026
Nextech Invest, Ltd. History No change 4,055,861 106,628 10.31% 8.64% 2 0 0.0% Q4 2025 Feb 17, 2026
Alta Partners Management Company, L.P. History Reduced 3,823,425 100,517 97.03% 95.15% 3 -256,871 -6.3% Q4 2025 Jan 13, 2026
Commodore Capital LP History No change 3,375,000 88,728 5.91% 2.3% 4 0 0.0% Q4 2025 Feb 17, 2026
Canaan Partners XI LLC History Reduced 3,374,329 88,711 64.85% 49.07% 5 -233,780 -6.48% Q4 2025 Feb 13, 2026
JANUS HENDERSON GROUP PLC History Added to 2,935,442 77,084 0.03% 0.02% 6 +60,638 2.11% Q4 2025 Feb 17, 2026
TCG Crossover Management, LLC History No change 2,898,103 76,191 2.52% 1.99% 7 0 0.0% Q4 2025 Feb 17, 2026
Vestal Point Capital, LP History No change 2,425,000 63,753 2.17% 1.53% 8 0 0.0% Q4 2025 Feb 17, 2026
BVF INC/IL History Reduced 2,127,665 55,936 1.88% 2.07% 9 -1,522,129 -41.7% Q4 2025 Feb 17, 2026
BlackRock, Inc. History Added to 2,086,423 54,852 0.0% 0.0% 10 +216,949 11.6% Q4 2025 Feb 12, 2026
FARALLON CAPITAL MANAGEMENT LLC History Added to 2,066,818 54,336 0.26% 0.07% 11 +923,000 80.69% Q4 2025 Feb 17, 2026
VANGUARD GROUP INC History Added to 1,572,785 41,348 0.0% 0.0% 12 +52,600 3.46% Q4 2025 Jan 29, 2026
Kynam Capital Management, LP History Reduced 1,564,492 41,130 2.63% 2.43% 13 -765,506 -32.85% Q4 2025 Feb 17, 2026
5AM Venture Management, LLC History Added to 1,029,298 27,060 8.51% 4.81% 14 +90,000 9.58% Q4 2025 Feb 17, 2026
Caligan Partners LP History Added to 944,257 24,824 2.04% 1.28% 15 +247,432 35.51% Q4 2025 Feb 17, 2026
Point72 Asset Management, L.P. History Added to 874,192 22,982 0.03% 0.01% 16 +592,160 209.96% Q4 2025 Feb 17, 2026
BALYASNY ASSET MANAGEMENT L.P. History Reduced 818,326 21,513 0.03% 0.02% 17 -28,259 -3.34% Q4 2025 Feb 17, 2026
STATE STREET CORP History Added to 749,463 19,703 0.0% 0.0% 18 +320,991 74.92% Q4 2025 Feb 13, 2026
MARSHALL WACE, LLP History Added to 711,891 18,715 0.02% 0.01% 19 +109,876 18.25% Q4 2025 Feb 13, 2026
Trails Edge Capital Partners, LP History New 700,000 18,403 4.55% 20 +700,000 New Q4 2025 Feb 17, 2026
GEODE CAPITAL MANAGEMENT, LLC History Added to 657,756 17,296 0.0% 0.0% 21 +60,302 10.09% Q4 2025 Feb 09, 2026
Sio Capital Management, LLC History Added to 526,002 13,828 2.18% 1.82% 22 +11,055 2.15% Q4 2025 Feb 17, 2026
BOONE CAPITAL MANAGEMENT LLC History New 398,482 10,476 3.29% 23 +398,482 New Q4 2025 Feb 17, 2026
Elmind Capital, LP History New 350,000 9,201 2.72% 24 +350,000 New Q4 2025 Feb 17, 2026
Eversept Partners, LP History Added to 278,564 7,323 0.37% 0.26% 25 +5,858 2.15% Q4 2025 Feb 17, 2026
BOOTHBAY FUND MANAGEMENT, LLC History Added to 221,177 5,814 0.09% 0.04% 26 +34,507 18.49% Q4 2025 Feb 17, 2026
Logos Global Management LP History New 210,000 5,520 0.33% 27 +210,000 New Q4 2025 Feb 17, 2026
NORTHERN TRUST CORP History Reduced 200,956 5,283 0.0% 0.0% 28 -7,530 -3.61% Q4 2025 Feb 17, 2026
CHARLES SCHWAB INVESTMENT MANAGEMENT INC History Reduced 199,426 5,242 0.0% 0.0% 29 -2,161 -1.07% Q4 2025 Feb 13, 2026
GOLDMAN SACHS GROUP INC History Added to 182,387 4,794 0.0% 0.0% 30 +82,237 82.11% Q4 2025 Mar 25, 2026
RAYMOND JAMES FINANCIAL INC History Added to 170,032 4,470 0.0% 0.0% 31 +43,658 34.55% Q4 2025 Feb 18, 2026
BNP Paribas Asset Management Holding S.A. History New 129,779 3,412 0.0% 32 +129,779 New Q4 2025 Feb 13, 2026
JACOBS LEVY EQUITY MANAGEMENT, INC History New 129,753 3,411 0.01% 33 +129,753 New Q4 2025 Feb 13, 2026
Invesco Ltd. History Added to 129,435 3,402 0.0% 0.0% 34 +113,925 734.53% Q4 2025 Feb 19, 2026
Soleus Capital Management, L.P. History New 125,000 3,286 0.12% 35 +125,000 New Q4 2025 Feb 12, 2026
BNP PARIBAS FINANCIAL MARKETS History Reduced 120,278 3,162 0.0% 0.0% 36 -8,603 -6.68% Q4 2025 Feb 10, 2026
MORGAN STANLEY History Reduced 118,898 3,125 0.0% 0.0% 37 -203,245 -63.09% Q4 2025 Feb 13, 2026
MILLENNIUM MANAGEMENT LLC History Reduced 114,388 3,007 0.0% 0.0% 38 -29,628 -20.57% Q4 2025 Feb 17, 2026
TWO SIGMA INVESTMENTS, LP History Reduced 107,023 2,813 0.0% 0.0% 39 -92,415 -46.34% Q4 2025 Feb 17, 2026
WELLINGTON MANAGEMENT GROUP LLP History Added to 104,305 2,742 0.0% 0.0% 40 +21,434 25.86% Q4 2025 Feb 17, 2026
DIMENSIONAL FUND ADVISORS LP History Added to 95,640 2,514 0.0% 0.0% 41 +55,961 141.03% Q4 2025 Feb 12, 2026
INVESTMENT COUNSEL CO OF NEVADA History No change 85,020 2,235 4.8% 2.42% 42 0 0.0% Q4 2025 Feb 13, 2026
OPPENHEIMER & CO INC History Added to 84,726 2,227 0.03% 0.01% 43 +2,488 3.03% Q4 2025 Feb 02, 2026
Seven Fleet Capital Management LP History New 79,560 2,091 1.42% 44 +79,560 New Q4 2025 Apr 02, 2026
BARCLAYS PLC History Added to 76,309 2,006 0.0% 0.0% 45 +19,183 33.58% Q4 2025 Feb 13, 2026
Kalehua Capital Management LLC History New 74,465 1,957 1.94% 46 +74,465 New Q4 2025 Feb 13, 2026
JPMORGAN CHASE & CO History Reduced 71,175 1,871 0.0% 0.0% 47 -3,054 -4.11% Q4 2025 Feb 11, 2026
Bank of New York Mellon Corp History Added to 60,901 1,601 0.0% 0.0% 48 +3,739 6.54% Q4 2025 Feb 10, 2026
TWO SIGMA ADVISERS, LP History Reduced 58,900 1,548 0.0% 0.0% 49 -54,300 -47.97% Q4 2025 Feb 17, 2026
UBS Group AG History Reduced 58,856 1,547 0.0% 0.0% 50 -288 -0.49% Q4 2025 Jan 29, 2026
SUPERSTRING CAPITAL MANAGEMENT LP History New 58,677 1,542 0.83% 51 +58,677 New Q4 2025 Feb 17, 2026
SUSQUEHANNA INTERNATIONAL GROUP, LLP History New 55,135 1,449 0.0% 52 +55,135 New Q4 2025 Feb 17, 2026
AMERIPRISE FINANCIAL INC History Reduced 54,625 1,436 0.0% 0.0% 53 -32,482 -37.29% Q4 2025 Feb 17, 2026
Squarepoint Ops LLC History Added to 54,424 1,430 0.0% 0.0% 54 +42,210 345.59% Q4 2025 Feb 13, 2026
Susquehanna Portfolio Strategies, LLC History No change 48,644 1,278 0.02% 0.01% 55 0 0.0% Q4 2025 Feb 17, 2026
Nuveen, LLC History Reduced 47,349 1,244 0.0% 0.0% 56 -33,092 -41.14% Q4 2025 Feb 12, 2026
ALGERT GLOBAL LLC History New 46,870 1,232 0.02% 57 +46,870 New Q4 2025 Feb 17, 2026
AMERICAN CENTURY COMPANIES INC History Added to 46,227 1,215 0.0% 0.0% 58 +7,815 20.35% Q4 2025 Feb 13, 2026
Y-Intercept (Hong Kong) Ltd History New 45,942 1,207 0.03% 59 +45,942 New Q4 2025 Feb 13, 2026
ALPS ADVISORS INC History Added to 43,827 1,152 0.01% 0.0% 60 +19,127 77.44% Q4 2025 Feb 12, 2026
ExodusPoint Capital Management, LP History New 42,791 1,124 0.01% 61 +42,791 New Q4 2025 Feb 17, 2026
PDT Partners, LLC History Reduced 42,284 1,111 0.07% 0.04% 62 -1,026 -2.37% Q4 2025 Feb 17, 2026
STATE OF WISCONSIN INVESTMENT BOARD History Added to 39,023 1,025 0.0% 0.0% 63 +9,375 31.62% Q4 2025 Feb 17, 2026
RHUMBLINE ADVISERS History Reduced 38,790 1,019 0.0% 0.0% 64 -1,846 -4.54% Q4 2025 Feb 13, 2026
BANK OF AMERICA CORP /DE/ History Reduced 38,310 1,007 0.0% 0.0% 65 -96,009 -71.48% Q4 2025 Feb 17, 2026
HighVista Strategies LLC History Reduced 35,086 922 0.24% 0.23% 66 -30,726 -46.69% Q4 2025 Feb 17, 2026
ALLIANCEBERNSTEIN L.P. History Reduced 31,990 841 0.0% 0.0% 67 -1,270 -3.82% Q4 2025 Feb 17, 2026
XTX Topco Ltd History Reduced 30,414 799 0.02% 0.02% 68 -3,286 -9.75% Q4 2025 Feb 17, 2026
VOYA INVESTMENT MANAGEMENT LLC History New 29,887 785 0.0% 69 +29,887 New Q4 2025 Feb 12, 2026
WELLS FARGO & COMPANY/MN History Added to 29,049 763 0.0% 0.0% 70 +10,579 57.28% Q4 2025 Feb 13, 2026
CANADA PENSION PLAN INVESTMENT BOARD History New 28,900 759 0.0% 71 +28,900 New Q4 2025 Feb 17, 2026
Fisher Asset Management, LLC History New 28,800 757 0.0% 72 +28,800 New Q4 2025 Feb 09, 2026
AQR CAPITAL MANAGEMENT LLC History Added to 28,631 752 0.0% 0.0% 73 +562 2.0% Q4 2025 Feb 17, 2026
PSP Research LLC History New 21,853 574 0.5% 74 +21,853 New Q4 2025 Feb 06, 2026
Auour Investments LLC History No change 21,020 552 0.18% 0.1% 75 0 0.0% Q4 2025 Jan 12, 2026
Creative Planning History New 19,603 515 0.0% 76 +19,603 New Q4 2025 Feb 17, 2026
VICTORY CAPITAL MANAGEMENT INC History No change 18,790 493 0.0% 0.0% 77 0 0.0% Q4 2025 Feb 13, 2026
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO History Reduced 18,542 487 0.0% 0.0% 78 -6,420 -25.72% Q4 2025 Feb 17, 2026
DEUTSCHE BANK AG\ History Added to 16,377 430 0.0% 0.0% 79 +894 5.77% Q4 2025 Feb 11, 2026
Rafferty Asset Management, LLC History New 15,455 406 0.0% 80 +15,455 New Q4 2025 Feb 13, 2026
MetLife Investment Management, LLC History Added to 15,356 403 0.0% 0.0% 81 +725 4.96% Q4 2025 Feb 12, 2026
PRICE T ROWE ASSOCIATES INC /MD/ History Added to 14,432 380 0.0% 0.0% 82 +1,631 12.74% Q4 2025 Feb 17, 2026
Russell Investments Group, Ltd. History Added to 12,996 341 0.0% 0.0% 83 +255 2.0% Q4 2025 Feb 17, 2026
FRANKLIN RESOURCES INC History New 12,970 340 0.0% 84 +12,970 New Q4 2025 Feb 11, 2026
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. History Added to 12,908 338 0.0% 0.0% 85 +1,591 14.06% Q4 2025 Feb 17, 2026
FMR LLC History Added to 12,563 330 0.0% 0.0% 86 +34 0.27% Q4 2025 Feb 17, 2026
CITADEL ADVISORS LLC History Reduced 12,500 328 0.0% 0.0% 87 -122,293 -90.73% Q4 2025 Feb 17, 2026
Virtus Investment Advisers, LLC History Added to 11,756 309 0.08% 0.04% 88 +741 6.73% Q4 2025 Feb 17, 2026
BANK OF NOVA SCOTIA History New 11,100 291 0.0% 89 +11,100 New Q4 2025 Feb 13, 2026
BAKER BROS. ADVISORS LP History No change 10,607 278 0.0% 0.0% 90 0 0.0% Q4 2025 Feb 17, 2026
INTECH INVESTMENT MANAGEMENT LLC History Reduced 9,801 257 0.0% 0.0% 91 -1,601 -14.04% Q4 2025 Feb 10, 2026
VARCOV Co. History New 9,708 255 0.1% 92 +9,708 New Q4 2025 Feb 17, 2026
China Universal Asset Management Co., Ltd. History Reduced 8,697 228 0.02% 0.01% 93 -645 -6.9% Q4 2025 Jan 29, 2026
MANUFACTURERS LIFE INSURANCE COMPANY, THE History New 8,357 219 0.0% 94 +8,357 New Q4 2025 Feb 13, 2026
NEW YORK STATE COMMON RETIREMENT FUND History No change 7,423 195 0.0% 0.0% 95 0 0.0% Q4 2025 Feb 12, 2026
Police & Firemen's Retirement System of New Jersey History No change 6,440 169 0.0% 0.0% 96 0 0.0% Q4 2025 Feb 13, 2026
Caitong International Asset Management Co., Ltd History New 5,994 157 0.04% 97 +5,994 New Q4 2025 Mar 03, 2026
CITIGROUP INC History Added to 3,817 100 0.0% 0.0% 98 +2,110 123.61% Q4 2025 Feb 13, 2026
Bellevue Group AG History New 3,143 82 0.0% 99 +3,143 New Q4 2025 Feb 17, 2026
Mirae Asset Global Investments Co., Ltd. History Added to 2,594 68 0.0% 0.0% 100 +534 25.92% Q4 2025 Jan 26, 2026
Legal & General Group Plc History Added to 2,367 62 0.0% 0.0% 101 +175 7.98% Q4 2025 Feb 09, 2026
AlphaQuest LLC History Reduced 2,139 56 0.0% 0.03% 102 -27,921 -92.88% Q4 2025 Feb 09, 2026
Chung Wu Investment Group, LLC History New 2,000 52 0.04% 104 +2,000 New Q4 2025 Feb 02, 2026
Ameritas Investment Partners, Inc. History No change 1,991 52 0.0% 0.0% 103 0 0.0% Q4 2025 Feb 11, 2026
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM History Added to 1,595 41 0.0% 0.0% 105 +122 8.28% Q4 2025 Feb 17, 2026
CWM, LLC History Added to 1,546 41 0.0% 0.0% 106 +17 1.11% Q4 2025 Jan 26, 2026
Sterling Capital Management LLC History Reduced 1,488 39 0.0% 0.0% 107 -174 -10.47% Q4 2025 Feb 13, 2026
FEDERATED HERMES, INC. History Reduced 1,297 34 0.0% 0.0% 108 -858 -39.81% Q4 2025 Feb 12, 2026
OSAIC HOLDINGS, INC. History Reduced 1,188 31 0.0% 0.0% 109 -4 -0.34% Q4 2025 Feb 17, 2026
GF FUND MANAGEMENT CO. LTD. History Reduced 1,048 27 0.0% 0.0% 110 -99 -8.63% Q4 2025 Jan 27, 2026
AMALGAMATED BANK History Added to 814 21 0.0% 0.0% 111 +113 16.12% Q4 2025 Feb 05, 2026
Versant Capital Management, Inc History No change 819 21 0.0% 0.0% 112 0 0.0% Q4 2025 Jan 08, 2026
ROYAL BANK OF CANADA History New 742 19 0.0% 113 +742 New Q4 2025 Feb 17, 2026
STRS OHIO History No change 700 18 0.0% 0.0% 114 0 0.0% Q4 2025 Feb 02, 2026
GAMMA Investing LLC History Added to 472 12 0.0% 0.0% 115 +161 51.77% Q4 2025 Jan 05, 2026
Tower Research Capital LLC (TRC) History Reduced 331 8 0.0% 0.0% 116 -543 -62.13% Q4 2025 Feb 17, 2026
PNC FINANCIAL SERVICES GROUP, INC. History No change 208 5 0.0% 0.0% 117 0 0.0% Q4 2025 Feb 06, 2026
Daiwa Securities Group Inc. History No change 173 5 0.0% 0.0% 118 0 0.0% Q4 2025 Feb 11, 2026
Optiver Holding B.V. History Reduced 128 3 0.0% 0.0% 120 -240 -65.22% Q4 2025 Feb 17, 2026
Smartleaf Asset Management LLC History New 127 3 0.0% 122 +127 New Q4 2025 Feb 13, 2026
Larson Financial Group LLC History Added to 146 3 0.0% 0.0% 119 +8 5.8% Q4 2025 Feb 06, 2026
True Wealth Design, LLC History No change 142 3 0.0% 0.0% 121 0 0.0% Q4 2025 Jan 08, 2026
Allworth Financial LP History New 100 2 0.0% 124 +100 New Q4 2025 Feb 05, 2026
Rockefeller Capital Management L.P. History New 84 2 0.0% 126 +84 New Q4 2025 Mar 16, 2026
Steward Partners Investment Advisory, LLC History New 77 2 0.0% 125 +77 New Q4 2025 Feb 12, 2026
NISA INVESTMENT ADVISORS, LLC History No change 86 2 0.0% 0.0% 123 0 0.0% Q4 2025 Jan 15, 2026
Farther Finance Advisors, LLC History Added to 60 1 0.0% 130 +49 445.45% Q4 2025 Jan 23, 2026
EverSource Wealth Advisors, LLC History Reduced 42 1 0.0% 129 -2 -4.55% Q4 2025 Feb 06, 2026
ROTHSCHILD INVESTMENT LLC History No change 55 1 0.0% 127 0 0.0% Q4 2025 Feb 10, 2026
SIGNATUREFD, LLC History No change 43 1 0.0% 128 0 0.0% Q4 2025 Jan 20, 2026
Walleye Capital LLC History Closed out 0 0 0.02% -297,808 -100.0% Q3 2025 Nov 14, 2025
RENAISSANCE TECHNOLOGIES LLC History Closed out 0 0 0.0% -170,100 -100.0% Q3 2025 Nov 13, 2025
Jump Financial, LLC History Closed out 0 0 0.01% -62,000 -100.0% Q3 2025 Nov 13, 2025
JANE STREET GROUP, LLC History Closed out 0 0 0.0% -44,680 -100.0% Q3 2025 Nov 14, 2025
Brevan Howard Capital Management LP History Closed out 0 0 0.0% -31,101 -100.0% Q3 2025 Nov 14, 2025
Trexquant Investment LP History Closed out 0 0 0.0% -15,758 -100.0% Q3 2025 Nov 14, 2025
TUDOR INVESTMENT CORP ET AL History Closed out 0 0 0.7% -10,761 -100.0% Q3 2025 Dec 09, 2025
SG Americas Securities, LLC History Closed out 0 0 0.0% -9,542 -100.0% Q3 2025 Oct 23, 2025
Clearstead Advisors, LLC History Reduced 29 0 0.0% -96 -76.8% Q4 2025 Feb 09, 2026
Arax Advisory Partners History Reduced 3 0 0.0% -82 -96.47% Q4 2025 Feb 13, 2026
Rise Advisors, LLC History Closed out 0 0 -49 -100.0% Q3 2025 Oct 08, 2025
SBI Securities Co., Ltd. History Reduced 4 0 -1 -20.0% Q4 2025 Feb 03, 2026
Covestor Ltd History No change 6 0 0 0.0% Q4 2025 Feb 06, 2026