Upstream Bio, Inc. - UPB

Detailed investor-level table based on 13F positions.

Shareholders (13F)

Quarter: Q3 2026 · Compare: Q2 2026
13D/13G major owners: Ownership tab.
Methodology: Market value and % of portfolio use SEC reported VALUE ($000). For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received. Details.
Rows: 0
Investor History Status Shares held Market value ($000) % of portfolio Previous % Rank Change in shares % change in shares Source Date reported
FMR LLC History No change 8,162,897 56,487 0.0% 0.0% 1 0 0.0% Q2 2026 Aug 13, 2026
ORBIMED ADVISORS LLC History No change 5,693,589 39,399 0.73% 0.73% 2 0 0.0% Q2 2026 Aug 14, 2026
NORGES BANK History No change 3,768,619 26,078 0.0% 0.0% 3 0 0.0% Q2 2026 Aug 12, 2026
BlackRock, Inc. History No change 3,753,358 25,973 0.0% 0.0% 4 0 0.0% Q2 2026 Aug 07, 2026
Decheng Capital LLC History No change 2,724,868 18,856 2.58% 2.58% 5 0 0.0% Q2 2026 Aug 14, 2026
Enavate Sciences GP, LLC History No change 2,459,703 17,021 4.93% 4.93% 6 0 0.0% Q2 2026 Aug 14, 2026
VANGUARD CAPITAL MANAGEMENT LLC History No change 1,876,734 12,986 0.0% 0.0% 7 0 0.0% Q2 2026 Aug 13, 2026
MILLENNIUM MANAGEMENT LLC History No change 1,143,775 7,914 0.0% 0.0% 8 0 0.0% Q2 2026 Aug 14, 2026
D. E. Shaw & Co., Inc. History No change 1,036,044 7,169 0.0% 0.0% 9 0 0.0% Q2 2026 Aug 14, 2026
JPMORGAN CHASE & CO History No change 1,012,044 7,013 0.0% 0.0% 10 0 0.0% Q2 2026 Aug 12, 2026
Qube Research & Technologies Ltd History No change 978,500 6,771 0.01% 0.01% 11 0 0.0% Q2 2026 Aug 14, 2026
Parkman Healthcare Partners LLC History No change 935,247 6,471 0.66% 0.66% 12 0 0.0% Q2 2026 Aug 14, 2026
GEODE CAPITAL MANAGEMENT, LLC History No change 931,261 6,445 0.0% 0.0% 13 0 0.0% Q2 2026 Aug 12, 2026
SEB Asset Management AB History No change 878,473 6,079 0.02% 0.02% 14 0 0.0% Q2 2026 Aug 04, 2026
Woodline Partners LP History No change 831,481 5,753 0.02% 0.02% 15 0 0.0% Q2 2026 Aug 14, 2026
STATE STREET CORP History No change 766,323 5,302 0.0% 0.0% 16 0 0.0% Q2 2026 Sep 22, 2026
VANGUARD PORTFOLIO MANAGEMENT LLC History No change 712,667 4,931 0.0% 0.0% 17 0 0.0% Q2 2026 Aug 13, 2026
Y-Intercept (Hong Kong) Ltd History No change 693,555 4,799 0.09% 0.09% 18 0 0.0% Q2 2026 Jul 13, 2026
Bain Capital Life Sciences Investors, LLC History No change 600,949 4,158 0.25% 0.25% 19 0 0.0% Q2 2026 Aug 14, 2026
AQR CAPITAL MANAGEMENT LLC History No change 544,869 3,770 0.0% 0.0% 20 0 0.0% Q2 2026 Aug 14, 2026
MORGAN STANLEY History No change 524,632 3,630 0.0% 0.0% 21 0 0.0% Q2 2026 Aug 13, 2026
BNP PARIBAS FINANCIAL MARKETS History No change 511,546 3,539 0.0% 0.0% 22 0 0.0% Q2 2026 Aug 13, 2026
Walleye Capital LLC History No change 498,490 3,449 0.01% 0.01% 23 0 0.0% Q2 2026 Aug 03, 2026
Trexquant Investment LP History No change 466,430 3,227 0.02% 0.02% 24 0 0.0% Q2 2026 Aug 14, 2026
Point72 Asset Management, L.P. History No change 453,011 3,134 0.0% 0.0% 25 0 0.0% Q2 2026 Aug 14, 2026
BANK OF AMERICA CORP /DE/ History No change 391,762 2,710 0.0% 0.0% 26 0 0.0% Q2 2026 Aug 14, 2026
DIMENSIONAL FUND ADVISORS LP History No change 381,613 2,640 0.0% 0.0% 27 0 0.0% Q2 2026 Aug 11, 2026
Altshuler Shaham Ltd History No change 380,061 2,630 0.03% 0.03% 28 0 0.0% Q2 2026 Aug 12, 2026
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP History No change 357,756 2,475 0.0% 0.0% 29 0 0.0% Q2 2026 Aug 13, 2026
Samsara BioCapital, LLC History No change 353,717 2,447 0.2% 0.2% 30 0 0.0% Q2 2026 Aug 14, 2026
Propel Bio Management, LLC History No change 350,389 2,424 1.27% 1.27% 31 0 0.0% Q2 2026 Aug 13, 2026
WELLINGTON MANAGEMENT GROUP LLP History No change 342,353 2,369 0.0% 0.0% 32 0 0.0% Q2 2026 Aug 14, 2026
NORTHERN TRUST CORP History No change 297,346 2,057 0.0% 0.0% 33 0 0.0% Q2 2026 Aug 13, 2026
Squarepoint Ops LLC History No change 290,904 2,013 0.0% 0.0% 34 0 0.0% Q2 2026 Aug 14, 2026
Voleon Capital Management LP History No change 285,234 1,973 0.04% 0.04% 35 0 0.0% Q2 2026 Aug 14, 2026
CHARLES SCHWAB INVESTMENT MANAGEMENT INC History No change 262,456 1,816 0.0% 0.0% 36 0 0.0% Q2 2026 Aug 14, 2026
JACOBS LEVY EQUITY MANAGEMENT, INC History No change 253,092 1,751 0.01% 0.01% 37 0 0.0% Q2 2026 Aug 14, 2026
GOLDMAN SACHS GROUP INC History No change 246,917 1,708 0.0% 0.0% 38 0 0.0% Q2 2026 Aug 14, 2026
XTX Topco Ltd History No change 242,346 1,677 0.02% 0.02% 39 0 0.0% Q2 2026 Aug 14, 2026
DEUTSCHE BANK AG\ History No change 241,447 1,670 0.0% 0.0% 40 0 0.0% Q2 2026 Aug 07, 2026
VANGUARD FIDUCIARY TRUST CO History No change 239,616 1,658 0.0% 0.0% 41 0 0.0% Q2 2026 Aug 13, 2026
UBS Group AG History No change 234,714 1,624 0.0% 0.0% 42 0 0.0% Q2 2026 Aug 13, 2026
Schonfeld Strategic Advisors LLC History No change 225,760 1,562 0.01% 0.01% 43 0 0.0% Q2 2026 Aug 14, 2026
Jump Financial, LLC History No change 223,223 1,544 0.01% 0.01% 44 0 0.0% Q2 2026 Aug 13, 2026
SPHERA FUNDS MANAGEMENT LTD. History No change 219,700 1,520 0.2% 0.2% 45 0 0.0% Q2 2026 Aug 14, 2026
ACADIAN ASSET MANAGEMENT LLC History No change 175,110 1,208 0.0% 0.0% 46 0 0.0% Q2 2026 Aug 13, 2026
HRT FINANCIAL LP History No change 170,590 1,180 0.0% 0.0% 47 0 0.0% Q2 2026 Aug 14, 2026
Boxer Capital Management, LLC History No change 150,000 1,038 0.08% 0.08% 48 0 0.0% Q2 2026 Aug 14, 2026
RENAISSANCE TECHNOLOGIES LLC History No change 131,300 908 0.0% 0.0% 49 0 0.0% Q2 2026 Aug 13, 2026
EntryPoint Capital, LLC History No change 129,446 895 0.22% 0.22% 50 0 0.0% Q2 2026 Aug 13, 2026
ALGERT GLOBAL LLC History No change 118,630 820 0.01% 0.01% 51 0 0.0% Q2 2026 Aug 13, 2026
Bank of New York Mellon Corp History No change 85,747 593 0.0% 0.0% 52 0 0.0% Q2 2026 Aug 06, 2026
Nuveen, LLC History No change 84,770 586 0.0% 0.0% 53 0 0.0% Q2 2026 Aug 11, 2026
AMERICAN CENTURY COMPANIES INC History No change 78,194 541 0.0% 0.0% 54 0 0.0% Q2 2026 Aug 12, 2026
Man Group plc History No change 73,823 510 0.0% 0.0% 55 0 0.0% Q2 2026 Aug 14, 2026
GSA CAPITAL PARTNERS LLP History No change 69,348 480 0.03% 0.03% 56 0 0.0% Q2 2026 Aug 06, 2026
ALLIANCEBERNSTEIN L.P. History No change 51,680 465 0.0% 0.0% 57 0 0.0% Q2 2026 Aug 14, 2026
Simplify Asset Management Inc. History No change 62,113 429 0.01% 0.01% 58 0 0.0% Q2 2026 Jul 16, 2026
ALPS ADVISORS INC History No change 55,228 382 0.0% 0.0% 59 0 0.0% Q2 2026 Jul 29, 2026
Quantinno Capital Management LP History No change 54,838 379 0.0% 0.0% 60 0 0.0% Q2 2026 Aug 13, 2026
Virtus Investment Advisers, LLC History No change 53,638 371 0.09% 0.09% 61 0 0.0% Q2 2026 Aug 11, 2026
Invesco Ltd. History No change 53,397 369 0.0% 0.0% 62 0 0.0% Q2 2026 Aug 14, 2026
Brevan Howard Capital Management LP History No change 50,369 348 0.0% 0.0% 63 0 0.0% Q2 2026 Aug 14, 2026
Swiss National Bank History No change 48,100 332 0.0% 0.0% 64 0 0.0% Q2 2026 Aug 11, 2026
Russell Investments Group, Ltd. History No change 47,543 329 0.0% 0.0% 65 0 0.0% Q2 2026 Aug 06, 2026
Allspring Global Investments Holdings, LLC History No change 43,182 298 0.0% 0.0% 66 0 0.0% Q2 2026 Aug 13, 2026
RHUMBLINE ADVISERS History No change 42,384 293 0.0% 0.0% 67 0 0.0% Q2 2026 Aug 11, 2026
TWO SIGMA INVESTMENTS, LP History No change 42,325 292 0.0% 0.0% 68 0 0.0% Q2 2026 Aug 14, 2026
ExodusPoint Capital Management, LP History No change 41,045 284 0.0% 0.0% 69 0 0.0% Q2 2026 Aug 14, 2026
CITIGROUP INC History No change 40,339 279 0.0% 0.0% 70 0 0.0% Q2 2026 Aug 03, 2026
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM History No change 38,634 267 0.0% 0.0% 71 0 0.0% Q2 2026 Aug 24, 2026
Stonepine Capital Management, LLC History No change 33,432 231 0.13% 0.13% 72 0 0.0% Q2 2026 Aug 17, 2026
Mariner, LLC History No change 33,141 229 0.0% 0.0% 73 0 0.0% Q2 2026 Aug 13, 2026
WELLS FARGO & COMPANY/MN History No change 29,497 204 0.0% 0.0% 74 0 0.0% Q2 2026 Aug 14, 2026
BARCLAYS PLC History No change 29,208 202 0.0% 0.0% 75 0 0.0% Q2 2026 Aug 14, 2026
Creative Planning History No change 28,483 197 0.0% 0.0% 76 0 0.0% Q2 2026 Aug 13, 2026
PRICE T ROWE ASSOCIATES INC /MD/ History No change 28,058 195 0.0% 0.0% 77 0 0.0% Q2 2026 Aug 14, 2026
Quantbot Technologies LP History No change 28,178 194 0.01% 0.01% 78 0 0.0% Q2 2026 Aug 12, 2026
JANE STREET GROUP, LLC History No change 27,494 190 0.0% 0.0% 79 0 0.0% Q2 2026 Aug 14, 2026
AXQ CAPITAL, LP History No change 27,068 187 0.02% 0.02% 80 0 0.0% Q2 2026 Aug 06, 2026
nVerses Capital, LLC History No change 24,029 166 0.26% 0.26% 81 0 0.0% Q2 2026 Aug 04, 2026
DnB Asset Management AS History No change 23,600 163 0.0% 0.0% 82 0 0.0% Q2 2026 Aug 11, 2026
VANGUARD ASSET MANAGEMENT, Ltd History No change 22,724 157 0.0% 0.0% 83 0 0.0% Q2 2026 Aug 13, 2026
Graham Capital Management, L.P. History No change 22,508 155 0.0% 0.0% 84 0 0.0% Q2 2026 Aug 14, 2026
LOS ANGELES CAPITAL MANAGEMENT LLC History No change 22,385 154 0.0% 0.0% 85 0 0.0% Q2 2026 Aug 13, 2026
Verdad Advisers, LP History No change 21,810 150 0.14% 0.14% 86 0 0.0% Q2 2026 Aug 14, 2026
MetLife Investment Management, LLC History No change 20,852 144 0.0% 0.0% 87 0 0.0% Q2 2026 Aug 13, 2026
SG Americas Securities, LLC History No change 20,338 141 0.0% 0.0% 88 0 0.0% Q2 2026 Aug 07, 2026
SEI INVESTMENTS CO History No change 20,026 138 0.0% 0.0% 89 0 0.0% Q2 2026 Aug 14, 2026
WINTON GROUP Ltd History No change 19,800 137 0.0% 0.0% 90 0 0.0% Q2 2026 Aug 07, 2026
IEQ CAPITAL, LLC History No change 19,535 135 0.0% 0.0% 91 0 0.0% Q2 2026 Aug 11, 2026
DIADEMA PARTNERS LP History No change 19,093 132 0.02% 0.02% 92 0 0.0% Q2 2026 Aug 14, 2026
Quadrature Capital Ltd History No change 17,988 124 0.0% 0.0% 93 0 0.0% Q2 2026 Aug 06, 2026
Shay Capital LLC History No change 18,000 124 0.01% 0.01% 94 0 0.0% Q2 2026 Aug 14, 2026
Entropy Technologies, LP History No change 17,542 121 0.0% 0.0% 95 0 0.0% Q2 2026 Aug 13, 2026
STATE OF WISCONSIN INVESTMENT BOARD History No change 17,065 118 0.0% 0.0% 96 0 0.0% Q2 2026 Aug 14, 2026
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. History No change 16,217 112 0.0% 0.0% 97 0 0.0% Q2 2026 Aug 14, 2026
MANUFACTURERS LIFE INSURANCE COMPANY, THE History No change 15,735 108 0.0% 0.0% 98 0 0.0% Q2 2026 Sep 09, 2026
CITADEL ADVISORS LLC History No change 15,000 103 0.0% 0.0% 99 0 0.0% Q2 2026 Sep 02, 2026
MERCER GLOBAL ADVISORS INC /ADV History No change 13,352 92 0.0% 0.0% 100 0 0.0% Q2 2026 Aug 19, 2026
Vanguard Global Advisers, LLC History No change 13,059 90 0.0% 0.0% 101 0 0.0% Q2 2026 Aug 13, 2026
Legal & General Group Plc History No change 12,561 86 0.0% 0.0% 102 0 0.0% Q2 2026 Aug 14, 2026
Engineers Gate Manager LP History No change 12,491 86 0.0% 0.0% 103 0 0.0% Q2 2026 Aug 14, 2026
STRS OHIO History No change 12,000 83 0.0% 0.0% 104 0 0.0% Q2 2026 Jul 30, 2026
CANADA PENSION PLAN INVESTMENT BOARD History No change 11,500 79 0.0% 0.0% 105 0 0.0% Q2 2026 Aug 14, 2026
HSBC HOLDINGS PLC History No change 10,793 77 0.0% 0.0% 106 0 0.0% Q2 2026 Aug 14, 2026
PRELUDE CAPITAL MANAGEMENT, LLC History No change 10,550 73 0.01% 0.01% 107 0 0.0% Q2 2026 Aug 14, 2026
AMERIPRISE FINANCIAL INC History No change 10,487 72 0.0% 0.0% 108 0 0.0% Q2 2026 Aug 14, 2026
SUSQUEHANNA INTERNATIONAL GROUP, LLP History No change 10,100 69 0.0% 0.0% 109 0 0.0% Q2 2026 Aug 14, 2026
Police & Firemen's Retirement System of New Jersey History No change 9,456 65 0.0% 0.0% 110 0 0.0% Q2 2026 Jul 23, 2026
China Universal Asset Management Co., Ltd. History No change 8,661 59 0.0% 0.0% 111 0 0.0% Q2 2026 Jul 24, 2026
KLP KAPITALFORVALTNING AS History No change 5,900 40 0.0% 0.0% 112 0 0.0% Q2 2026 Aug 12, 2026
NEW YORK STATE COMMON RETIREMENT FUND History No change 5,200 35 0.0% 0.0% 113 0 0.0% Q2 2026 Jul 29, 2026
Tower Research Capital LLC (TRC) History No change 4,788 33 0.0% 0.0% 114 0 0.0% Q2 2026 Aug 11, 2026
Persistent Asset Partners Ltd History No change 4,855 33 0.01% 0.01% 115 0 0.0% Q2 2026 Aug 06, 2026
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO History No change 4,700 32 0.0% 0.0% 116 0 0.0% Q2 2026 Aug 17, 2026
NISA INVESTMENT ADVISORS, LLC History No change 4,278 29 0.0% 0.0% 117 0 0.0% Q2 2026 Aug 10, 2026
Vanguard Investments Australia, Ltd. History No change 4,096 28 0.0% 0.0% 118 0 0.0% Q2 2026 Aug 13, 2026
Ameritas Investment Partners, Inc. History No change 2,741 18 0.0% 0.0% 119 0 0.0% Q2 2026 Aug 13, 2026
Mirae Asset Global Investments Co., Ltd. History No change 2,434 16 0.0% 0.0% 120 0 0.0% Q2 2026 Jul 22, 2026
Arax Advisory Partners History No change 1,771 12 0.0% 0.0% 121 0 0.0% Q2 2026 Aug 10, 2026
Global Retirement Partners, LLC History No change 1,870 12 0.0% 0.0% 122 0 0.0% Q2 2026 Aug 06, 2026
GAMMA Investing LLC History Added to 1,628 8 0.0% 0.0% 123 +464 39.86% Q3 2026 Oct 08, 2026
ROYAL BANK OF CANADA History No change 1,091 7 0.0% 0.0% 124 0 0.0% Q2 2026 Aug 14, 2026
GF FUND MANAGEMENT CO. LTD. History No change 1,145 7 0.0% 0.0% 125 0 0.0% Q2 2026 Aug 07, 2026
Zurcher Kantonalbank (Zurich Cantonalbank) History No change 965 6 0.0% 0.0% 126 0 0.0% Q2 2026 Aug 11, 2026
Quarry LP History No change 893 6 0.0% 0.0% 127 0 0.0% Q2 2026 Aug 14, 2026
Allworth Financial LP History No change 778 5 0.0% 0.0% 128 0 0.0% Q2 2026 Aug 11, 2026
Rockefeller Capital Management L.P. History No change 738 5 0.0% 0.0% 129 0 0.0% Q2 2026 Aug 13, 2026
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC History No change 588 4 0.0% 0.0% 130 0 0.0% Q2 2026 Aug 13, 2026
Sterling Capital Management LLC History No change 710 4 0.0% 0.0% 131 0 0.0% Q2 2026 Jul 28, 2026
PNC FINANCIAL SERVICES GROUP, INC. History No change 387 2 0.0% 0.0% 132 0 0.0% Q2 2026 Aug 07, 2026
Farther Finance Advisors, LLC History Reduced 254 1 0.0% 0.0% 138 -99 -28.05% Q3 2026 Oct 08, 2026
US BANCORP \DE\ History No change 264 1 0.0% 0.0% 133 0 0.0% Q2 2026 Aug 12, 2026
ROTHSCHILD INVESTMENT LLC History No change 287 1 0.0% 0.0% 134 0 0.0% Q2 2026 Aug 06, 2026
IFP Advisors, Inc History No change 242 1 0.0% 0.0% 135 0 0.0% Q2 2026 Jul 20, 2026
EverSource Wealth Advisors, LLC History No change 272 1 0.0% 0.0% 136 0 0.0% Q2 2026 Jul 24, 2026
Physician Wealth Advisors, Inc. History No change 160 1 0.0% 0.0% 137 0 0.0% Q2 2026 Jul 20, 2026
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC History Closed out 0 0 — 0.0% — -10,017 -100.0% Q3 2026 Oct 13, 2026
Essential Partners LLC History Reduced 95 0 — 0.0% — -51 -34.93% Q3 2026 Oct 14, 2026
True Wealth Design, LLC History New 2 0 — — — +2 New Q3 2026 Oct 13, 2026
Clearstead Advisors, LLC History No change 15 0 — — — 0 0.0% Q2 2026 Aug 06, 2026
NATIONAL BANK OF CANADA /FI/ History No change 1 0 — — — 0 0.0% Q2 2026 Aug 10, 2026
SIMPLEX TRADING, LLC History No change 20 0 — — — 0 0.0% Q2 2026 Aug 12, 2026
OSAIC HOLDINGS, INC. History No change 19 0 — — — 0 0.0% Q2 2026 Aug 14, 2026
N.E.W. Advisory Services LLC History No change 120 0 — — — 0 0.0% Q2 2026 Aug 06, 2026
SJS Investment Consulting Inc. History No change 76 0 — — — 0 0.0% Q2 2026 Jul 22, 2026
Covestor Ltd History No change 39 0 — — — 0 0.0% Q2 2026 Aug 07, 2026
Freestone Grove Partners LP History No change 1 0 — — — 0 0.0% Q2 2026 Aug 14, 2026
JPL Wealth Management, LLC History No change 14 0 — — — 0 0.0% Q2 2026 Aug 13, 2026
Silver Grove Financial Group, Inc. History No change 28 0 — — — 0 0.0% Q2 2026 Aug 13, 2026