Upstream Bio, Inc. - UPB

Detailed investor-level table based on 13F positions.
Early Q1 2026 data: only 4 institutional holders reported so far. The full shareholder list will grow as more funds file with the SEC.

Shareholders (13F)

Quarter: Q4 2025 · Compare: Q3 2025
13D/13G major owners: Ownership tab.
Methodology: Market value and % of portfolio use SEC reported VALUE ($000). For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received. Details.
Rows: 0
Investor History Status Shares held Market value ($000) % of portfolio Previous % Rank Change in shares % change in shares Source Date reported
FMR LLC History Reduced 7,518,202 204,119 0.01% 0.01% 1 -568,211 -7.03% Q4 2025 Feb 17, 2026
ORBIMED ADVISORS LLC History No change 5,693,589 154,580 3.16% 2.52% 2 0 0.0% Q4 2025 Feb 17, 2026
BlackRock, Inc. History Added to 3,344,504 90,803 0.0% 0.0% 3 +740,798 28.45% Q4 2025 Feb 12, 2026
Decheng Capital LLC History Reduced 3,143,078 85,334 11.48% 10.78% 4 -142,215 -4.33% Q4 2025 Feb 12, 2026
NORGES BANK History New 2,882,647 78,263 0.01% 5 +2,882,647 New Q4 2025 Feb 10, 2026
Enavate Sciences GP, LLC History No change 2,459,703 66,780 13.18% 14.13% 6 0 0.0% Q4 2025 Feb 17, 2026
VANGUARD GROUP INC History Reduced 2,388,439 64,846 0.0% 0.0% 7 -54,112 -2.22% Q4 2025 Jan 29, 2026
UBS Group AG History Added to 1,806,243 49,039 0.01% 0.0% 8 +1,533,972 563.4% Q4 2025 Jan 29, 2026
JANUS HENDERSON GROUP PLC History New 1,527,958 41,422 0.02% 9 +1,527,958 New Q4 2025 Feb 17, 2026
Altshuler Shaham Ltd History Reduced 1,341,540 36,422 0.55% 0.44% 10 -75,282 -5.31% Q4 2025 Feb 17, 2026
Bain Capital Life Sciences Investors, LLC History Reduced 1,329,544 36,097 2.76% 3.05% 11 -1,109,994 -45.5% Q4 2025 Feb 17, 2026
Omega Fund Management, LLC History Reduced 1,326,293 36,008 12.57% 11.47% 12 -30,000 -2.21% Q4 2025 Feb 17, 2026
STATE STREET CORP History Added to 1,319,226 35,816 0.0% 0.0% 13 +204,645 18.36% Q4 2025 Feb 13, 2026
VR Adviser, LLC History No change 1,169,298 31,746 1.57% 1.24% 14 0 0.0% Q4 2025 Feb 17, 2026
WELLINGTON MANAGEMENT GROUP LLP History Reduced 894,733 24,292 0.0% 0.0% 15 -230,662 -20.5% Q4 2025 Feb 17, 2026
GEODE CAPITAL MANAGEMENT, LLC History Added to 851,908 23,134 0.0% 0.0% 16 +34,799 4.26% Q4 2025 Feb 09, 2026
Parkman Healthcare Partners LLC History Reduced 834,559 22,658 2.16% 1.65% 17 -8,943 -1.06% Q4 2025 Feb 17, 2026
Pictet Asset Management Holding SA History New 773,148 20,990 0.02% 18 +773,148 New Q4 2025 Jan 29, 2026
Woodline Partners LP History Added to 760,252 20,640 0.08% 0.05% 19 +158,000 26.23% Q4 2025 Feb 17, 2026
Integral Health Asset Management, LLC History Added to 750,000 20,362 1.01% 0.73% 20 +175,000 30.43% Q4 2025 Feb 17, 2026
TCG Crossover Management, LLC History Reduced 743,886 20,196 0.67% 1.96% 21 -1,373,217 -64.86% Q4 2025 Feb 17, 2026
Samsara BioCapital, LLC History Reduced 736,047 19,983 2.06% 2.36% 22 -226,107 -23.5% Q4 2025 Feb 17, 2026
Vestal Point Capital, LP History New 720,000 19,548 0.66% 23 +720,000 New Q4 2025 Feb 17, 2026
Siren, L.L.C. History Reduced 588,450 15,976 0.48% 0.58% 24 -200,000 -25.37% Q4 2025 Feb 13, 2026
BARCLAYS PLC History Added to 524,499 14,240 0.0% 0.0% 25 +439,184 514.78% Q4 2025 Feb 13, 2026
MILLENNIUM MANAGEMENT LLC History Added to 517,264 14,043 0.01% 0.0% 26 +477,151 1189.52% Q4 2025 Feb 17, 2026
Nantahala Capital Management, LLC History Reduced 494,971 13,438 0.44% 0.39% 27 -100,000 -16.81% Q4 2025 Feb 13, 2026
MARSHALL WACE, LLP History Reduced 343,791 9,333 0.01% 0.02% 28 -524,208 -60.39% Q4 2025 Feb 13, 2026
GOLDMAN SACHS GROUP INC History Added to 333,481 9,054 0.0% 0.0% 29 +110,267 49.4% Q4 2025 Mar 25, 2026
GREAT POINT PARTNERS LLC History No change 300,000 8,145 2.64% 2.33% 30 0 0.0% Q4 2025 Feb 17, 2026
Alyeska Investment Group, L.P. History New 298,329 8,099 0.02% 31 +298,329 New Q4 2025 Feb 13, 2026
JENNISON ASSOCIATES LLC History New 288,847 7,842 0.0% 32 +288,847 New Q4 2025 Jan 30, 2026
CHARLES SCHWAB INVESTMENT MANAGEMENT INC History Added to 284,931 7,735 0.0% 0.0% 33 +103 0.04% Q4 2025 Feb 13, 2026
NORTHERN TRUST CORP History Reduced 236,799 6,429 0.0% 0.0% 34 -17,920 -7.04% Q4 2025 Feb 17, 2026
Squadron Capital Management LLC History New 230,650 6,262 2.65% 35 +230,650 New Q4 2025 Feb 17, 2026
Invesco Ltd. History Added to 163,186 4,430 0.0% 0.0% 36 +145,996 849.31% Q4 2025 Feb 19, 2026
Boxer Capital Management, LLC History New 150,000 4,072 0.89% 37 +150,000 New Q4 2025 Feb 17, 2026
DEUTSCHE BANK AG\ History Added to 127,815 3,470 0.0% 0.0% 38 +101,078 378.05% Q4 2025 Feb 11, 2026
MORGAN STANLEY History Added to 122,068 3,314 0.0% 0.0% 39 +34,533 39.45% Q4 2025 Feb 13, 2026
SummitTX Capital, L.P. History Added to 116,724 3,169 0.1% 0.09% 40 +4,320 3.84% Q4 2025 Feb 17, 2026
SUSQUEHANNA INTERNATIONAL GROUP, LLP History New 115,841 3,145 0.0% 41 +115,841 New Q4 2025 Feb 17, 2026
Schonfeld Strategic Advisors LLC History Reduced 115,807 3,144 0.01% 0.02% 42 -74,437 -39.13% Q4 2025 Feb 17, 2026
JPMORGAN CHASE & CO History Added to 110,280 2,994 0.0% 0.0% 43 +80,333 268.25% Q4 2025 Feb 11, 2026
AMERICAN CENTURY COMPANIES INC History Added to 87,756 2,382 0.0% 0.0% 44 +16,216 22.67% Q4 2025 Feb 13, 2026
BANK OF AMERICA CORP /DE/ History Added to 86,384 2,345 0.0% 0.0% 45 +30,911 55.72% Q4 2025 Feb 17, 2026
Bank of New York Mellon Corp History Reduced 84,853 2,303 0.0% 0.0% 46 -6,668 -7.29% Q4 2025 Feb 10, 2026
Nuveen, LLC History Added to 78,568 2,133 0.0% 0.0% 47 +8,686 12.43% Q4 2025 Feb 12, 2026
ExodusPoint Capital Management, LP History New 75,402 2,047 0.02% 48 +75,402 New Q4 2025 Feb 17, 2026
Artia Global Partners LP History New 68,653 1,863 0.26% 49 +68,653 New Q4 2025 Feb 17, 2026
Exome Asset Management LLC History Added to 64,845 1,760 0.84% 0.59% 50 +12,885 24.8% Q4 2025 Feb 13, 2026
AMERIPRISE FINANCIAL INC History New 56,557 1,535 0.0% 51 +56,557 New Q4 2025 Feb 17, 2026
SEVEN GRAND MANAGERS, LLC History New 50,000 1,357 0.1% 52 +50,000 New Q4 2025 Feb 10, 2026
Y-Intercept (Hong Kong) Ltd History New 46,559 1,264 0.03% 53 +46,559 New Q4 2025 Feb 13, 2026
ALPS ADVISORS INC History Added to 44,376 1,204 0.01% 0.0% 54 +18,414 70.93% Q4 2025 Feb 12, 2026
RHUMBLINE ADVISERS History Reduced 41,523 1,127 0.0% 0.0% 55 -7,883 -15.96% Q4 2025 Feb 13, 2026
Rafferty Asset Management, LLC History Added to 38,683 1,050 0.0% 0.0% 56 +4,162 12.06% Q4 2025 Feb 13, 2026
WELLS FARGO & COMPANY/MN History Added to 36,794 998 0.0% 0.0% 57 +11,634 46.24% Q4 2025 Feb 13, 2026
Trexquant Investment LP History New 31,049 842 0.01% 58 +31,049 New Q4 2025 Feb 17, 2026
ALLIANCEBERNSTEIN L.P. History Added to 31,010 841 0.0% 0.0% 59 +11,160 56.22% Q4 2025 Feb 17, 2026
AQR CAPITAL MANAGEMENT LLC History Added to 30,503 828 0.0% 0.0% 60 +549 1.83% Q4 2025 Feb 17, 2026
D. E. Shaw & Co., Inc. History New 27,091 735 0.0% 61 +27,091 New Q4 2025 Feb 17, 2026
Swiss National Bank History New 26,600 722 0.0% 62 +26,600 New Q4 2025 Feb 12, 2026
CITADEL ADVISORS LLC History Reduced 23,420 635 0.0% 0.0% 63 -23,780 -50.38% Q4 2025 Feb 17, 2026
DIADEMA PARTNERS LP History Reduced 20,500 556 0.1% 0.96% 64 -179,500 -89.75% Q4 2025 Feb 17, 2026
MetLife Investment Management, LLC History Reduced 19,678 534 0.0% 0.0% 66 -2,013 -9.28% Q4 2025 Feb 12, 2026
PRICE T ROWE ASSOCIATES INC /MD/ History Added to 19,636 534 0.0% 0.0% 65 +1,135 6.13% Q4 2025 Feb 17, 2026
PSP Research LLC History New 17,634 478 0.42% 67 +17,634 New Q4 2025 Feb 06, 2026
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. History Added to 17,491 475 0.0% 0.0% 68 +628 3.72% Q4 2025 Feb 17, 2026
PRELUDE CAPITAL MANAGEMENT, LLC History Added to 16,560 449 0.03% 0.02% 69 +825 5.24% Q4 2025 Feb 17, 2026
RENAISSANCE TECHNOLOGIES LLC History New 16,400 445 0.0% 70 +16,400 New Q4 2025 Feb 12, 2026
Quantinno Capital Management LP History Added to 15,415 418 0.0% 0.0% 71 +526 3.53% Q4 2025 Feb 17, 2026
XTX Topco Ltd History New 15,091 409 0.01% 72 +15,091 New Q4 2025 Feb 17, 2026
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM History Added to 14,652 397 0.0% 0.0% 73 +12,476 573.35% Q4 2025 Feb 17, 2026
PROFUND ADVISORS LLC History New 14,582 395 0.01% 74 +14,582 New Q4 2025 Feb 06, 2026
Graham Capital Management, L.P. History New 13,712 372 0.01% 76 +13,712 New Q4 2025 Feb 17, 2026
Legal & General Group Plc History Added to 13,709 372 0.0% 0.0% 75 +10,785 368.84% Q4 2025 Feb 09, 2026
DnB Asset Management AS History New 12,793 347 0.0% 77 +12,793 New Q4 2025 Feb 05, 2026
Virtu Financial LLC History New 12,246 332 0.01% 78 +12,246 New Q4 2025 Feb 23, 2026
Verition Fund Management LLC History Reduced 12,020 326 0.0% 0.0% 79 -34,981 -74.43% Q4 2025 Feb 13, 2026
Mariner, LLC History Added to 11,830 321 0.0% 0.0% 80 +897 8.2% Q4 2025 Feb 13, 2026
Creative Planning History Reduced 11,749 318 0.0% 0.0% 81 -2,517 -17.64% Q4 2025 Feb 17, 2026
NEW YORK STATE COMMON RETIREMENT FUND History Added to 11,700 317 0.0% 0.0% 82 +5,400 85.71% Q4 2025 Feb 12, 2026
TWO SIGMA INVESTMENTS, LP History No change 10,500 285 0.0% 0.0% 83 0 0.0% Q4 2025 Feb 17, 2026
INTECH INVESTMENT MANAGEMENT LLC History No change 10,396 282 0.0% 0.0% 84 0 0.0% Q4 2025 Feb 10, 2026
MANUFACTURERS LIFE INSURANCE COMPANY, THE History New 10,147 275 0.0% 85 +10,147 New Q4 2025 Feb 13, 2026
STRS OHIO History New 9,800 266 0.0% 87 +9,800 New Q4 2025 Feb 02, 2026
Virtus Investment Advisers, LLC History Reduced 9,801 266 0.07% 0.05% 86 -42 -0.43% Q4 2025 Feb 17, 2026
Point72 Asset Management, L.P. History New 9,700 263 0.0% 88 +9,700 New Q4 2025 Feb 17, 2026
VARCOV Co. History New 9,619 261 0.1% 89 +9,619 New Q4 2025 Feb 17, 2026
Police & Firemen's Retirement System of New Jersey History Added to 9,456 256 0.0% 0.0% 90 +9 0.1% Q4 2025 Feb 13, 2026
Persistent Asset Partners Ltd History New 8,907 241 0.11% 91 +8,907 New Q4 2025 Feb 17, 2026
China Universal Asset Management Co., Ltd. History New 8,806 239 0.02% 92 +8,806 New Q4 2025 Jan 29, 2026
ProShare Advisors LLC History New 8,354 226 0.0% 93 +8,354 New Q4 2025 Feb 06, 2026
SEI INVESTMENTS CO History New 8,087 219 0.0% 94 +8,087 New Q4 2025 Feb 13, 2026
CITIGROUP INC History Reduced 6,949 188 0.0% 0.0% 95 -35,088 -83.47% Q4 2025 Feb 13, 2026
SG Americas Securities, LLC History New 5,518 150 0.0% 96 +5,518 New Q4 2025 Jan 09, 2026
BNP PARIBAS FINANCIAL MARKETS History Reduced 4,976 135 0.0% 0.0% 97 -1,551 -23.76% Q4 2025 Feb 10, 2026
CWM, LLC History Added to 3,360 91 0.0% 0.0% 98 +19 0.57% Q4 2025 Jan 26, 2026
KLP KAPITALFORVALTNING AS History New 2,900 78 0.0% 99 +2,900 New Q4 2025 Jan 28, 2026
Russell Investments Group, Ltd. History Reduced 2,823 76 0.0% 0.0% 100 -211 -6.95% Q4 2025 Feb 17, 2026
Ameritas Investment Partners, Inc. History No change 2,741 74 0.0% 0.0% 101 0 0.0% Q4 2025 Feb 11, 2026
Mirae Asset Global Investments Co., Ltd. History New 2,626 71 0.0% 102 +2,626 New Q4 2025 Jan 26, 2026
Sterling Capital Management LLC History Reduced 1,919 52 0.0% 0.0% 103 -345 -15.24% Q4 2025 Feb 13, 2026
Torren Management, LLC History New 1,099 29 0.01% 104 +1,099 New Q4 2025 Jan 30, 2026
GF FUND MANAGEMENT CO. LTD. History New 1,061 28 0.0% 106 +1,061 New Q4 2025 Jan 27, 2026
AMALGAMATED BANK History Added to 1,031 28 0.0% 0.0% 105 +437 73.57% Q4 2025 Feb 05, 2026
ROYAL BANK OF CANADA History New 969 26 0.0% 107 +969 New Q4 2025 Feb 17, 2026
GAMMA Investing LLC History Added to 900 24 0.0% 0.0% 108 +10 1.12% Q4 2025 Jan 05, 2026
Tower Research Capital LLC (TRC) History Reduced 669 18 0.0% 0.0% 109 -1,199 -64.19% Q4 2025 Feb 17, 2026
Versant Capital Management, Inc History Added to 558 15 0.0% 0.0% 110 +10 1.82% Q4 2025 Jan 08, 2026
US BANCORP \DE\ History Added to 546 14 0.0% 0.0% 111 +15 2.82% Q4 2025 Jan 30, 2026
FEDERATED HERMES, INC. History New 482 13 0.0% 112 +482 New Q4 2025 Feb 12, 2026
SIMPLEX TRADING, LLC History New 466 12 0.0% 113 +466 New Q4 2025 Feb 11, 2026
NISA INVESTMENT ADVISORS, LLC History Added to 400 10 0.0% 0.0% 114 +304 316.67% Q4 2025 Jan 15, 2026
Aster Capital Management (DIFC) Ltd History Reduced 271 7 0.0% 0.01% 117 -870 -76.25% Q4 2025 Feb 17, 2026
Global Retirement Partners, LLC History Reduced 273 7 0.0% 0.0% 116 -59 -17.77% Q4 2025 Feb 06, 2026
EverSource Wealth Advisors, LLC History Reduced 282 7 0.0% 0.0% 115 -28 -9.03% Q4 2025 Feb 06, 2026
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC History New 242 6 0.0% 118 +242 New Q4 2025 Feb 13, 2026
Daiwa Securities Group Inc. History New 180 5 0.0% 119 +180 New Q4 2025 Feb 11, 2026
SIGNATUREFD, LLC History Added to 117 3 0.0% 120 +66 129.41% Q4 2025 Jan 20, 2026
J.Safra Asset Management Corp History No change 128 3 0.0% 0.0% 121 0 0.0% Q4 2025 Feb 11, 2026
PNC FINANCIAL SERVICES GROUP, INC. History Reduced 106 2 0.0% 0.0% 122 -24 -18.46% Q4 2025 Feb 06, 2026
Allworth Financial LP History New 68 1 0.0% 123 +68 New Q4 2025 Feb 05, 2026
N.E.W. Advisory Services LLC History No change 60 1 0.0% 0.0% 124 0 0.0% Q4 2025 Jan 28, 2026
Ikarian Capital, LLC History Closed out 0 0 0.31% -161,113 -100.0% Q3 2025 Nov 14, 2025
NOMURA HOLDINGS INC History Closed out 0 0 0.0% -98,290 -100.0% Q3 2025 Nov 14, 2025
Caption Management, LLC History Closed out 0 0 0.01% -88,196 -100.0% Q3 2025 Nov 14, 2025
BALYASNY ASSET MANAGEMENT L.P. History Closed out 0 0 0.0% -73,131 -100.0% Q3 2025 Nov 14, 2025
BOOTHBAY FUND MANAGEMENT, LLC History Closed out 0 0 0.02% -61,299 -100.0% Q3 2025 Nov 14, 2025
JANE STREET GROUP, LLC History Closed out 0 0 0.0% -20,500 -100.0% Q3 2025 Nov 14, 2025
SIG BROKERAGE, LP History Closed out 0 0 0.01% -20,000 -100.0% Q3 2025 Nov 14, 2025
COMMONWEALTH EQUITY SERVICES, LLC History Closed out 0 0 0.0% -15,503 -100.0% Q3 2025 Oct 22, 2025
GROUP ONE TRADING LLC History Closed out 0 0 0.0% -1,305 -100.0% Q3 2025 Nov 12, 2025
Clearstead Advisors, LLC History Closed out 0 0 0.0% -163 -100.0% Q3 2025 Nov 10, 2025
Arax Advisory Partners History Reduced 2 0 0.0% -147 -98.66% Q4 2025 Feb 13, 2026
SageView Advisory Group, LLC History New 30 0 +30 New Q4 2025 Feb 17, 2026
Larson Financial Group LLC History New 14 0 +14 New Q4 2025 Feb 06, 2026
OSAIC HOLDINGS, INC. History New 5 0 +5 New Q4 2025 Feb 17, 2026
ROTHSCHILD INVESTMENT LLC History New 1 0 +1 New Q4 2025 Feb 10, 2026
IFP Advisors, Inc History Reduced 1 0 -1 -50.0% Q4 2025 Feb 06, 2026
Sunbelt Securities, Inc. History No change 19 0 0 0.0% Q4 2025 Feb 20, 2026
Parallel Advisors, LLC History No change 2 0 0 0.0% Q4 2025 Feb 11, 2026