HighVista Strategies LLC

Q3 2025 13F-HR Holdings

Location
Boston, MA
Holdings as of
9/30/2025
Date filed
11/14/2025
Form type
13F-HR
Num holdings
148
Total value ($000)
$407,966
Net value change ($000)
+135,834 (49.9%)
New positions
29
Sold out positions
27
Turnover %
21.3%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Prev filing: 8/14/2025 Next filing: 2/17/2026 SEC filing

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
ABVX 15,270 3905.4%
Merus N.V. 7,831 165.9%
CDTX 6,790 NEW
INSM 6,026 516.4%
MLYS 5,926 291.8%
RVMD 5,690 227.3%
ACLX 5,544 235.7%
AGIO 5,507 236.1%
CYTK 5,038 222.1%
PTGX 4,886 152.8%
Top Reduces (Value $000, Stocks/ETFs)
AKX -6,006 -100.0%
JNP -4,580 -100.0%
AHC -4,004 -100.0%
ADY -3,862 -100.0%
VRNA -2,731 -100.0%
SNPS -1,999 -100.0%
LYFT -1,983 -100.0%
CLF -1,943 -100.0%
CORZ -1,723 -56.1%
STX -1,562 -49.0%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type