ORBIMED ADVISORS LLC

Q3 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
9/30/2025
Date filed
11/14/2025
Form type
13F-HR
Num holdings
109
Total value ($000)
$4,255,380
Net value change ($000)
+251,269 (6.3%)
New positions
18
Sold out positions
17
Turnover %
17.8%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Prev filing: 8/14/2025 Next filing: 2/17/2026 SEC filing

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
DHR 52,162 NEW
EWTX 48,263 23.7%
UTHR 48,167 NEW
CI 46,927 NEW
MLYS 45,435 441.6%
SION 44,682 69.5%
UPB 44,580 71.3%
ORIC 34,573 378.8%
ABVX 32,262 NEW
ASND 32,216 542.6%
Top Reduces (Value $000, Stocks/ETFs)
SVA -149,531 -44.8%
UNH -104,916 -100.0%
VRTX -93,620 -100.0%
THC -81,840 -100.0%
BSX -64,993 -21.5%
SPRY -61,335 -42.4%
CYTK -35,584 -100.0%
LLY -33,353 -12.7%
Third Harmonic Bio, Inc. -31,380 -100.0%
NTRA -31,151 -31.1%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 85,619 (2.0% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type