ORBIMED ADVISORS LLC

Q3 2025 13F-HR Detailed Holdings

Location
New York, NY
Holdings as of
9/30/2025
Date filed
11/14/2025
Form type
13F-HR
Num holdings
110
Total value ($000)
$4,255,380
Net value change ($000)
+251,269 (6.3%)
New positions
18
Sold out positions
17
Turnover %
17.8%
Sector allocation + QoQ delta (equities-only)

Holdings broken out by other managers reported in the original SEC filing. View aggregated holdings

Prev filing: 8/14/2025 Next filing: 2/17/2026 SEC filing
You are on the SEC detailed breakdown page. Rows are shown as reported in the filing (including other manager, discretion, and voting authority fields), and are not merged like the standard holdings view. Switch to aggregated holdings.

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
DHR 52,162 NEW
EWTX 48,263 23.7%
UTHR 48,167 NEW
CI 46,927 NEW
MLYS 45,435 441.6%
SION 44,682 69.5%
UPB 44,580 71.3%
ORIC 34,573 378.8%
ABVX 32,262 NEW
ASND 32,216 542.6%
Top Reduces (Value $000, Stocks/ETFs)
SVA -149,531 -44.8%
UNH -104,916 -100.0%
VRTX -93,620 -100.0%
THC -81,840 -100.0%
BSX -64,993 -21.5%
SPRY -61,335 -42.4%
CYTK -35,584 -100.0%
LLY -33,353 -12.7%
Third Harmonic Bio, Inc. -31,380 -100.0%
NTRA -31,151 -31.1%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 85,619 (2.0% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type Discretion Other Manager Sole Shared None

Other Managers

Num Name File Number
1 ORBIMED CAPITAL LLC 028-10410