ORBIMED ADVISORS LLC

Q4 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
12/31/2025
Date filed
2/17/2026
Form type
13F-HR
Num holdings
108
Total value ($000)
$4,899,392
Net value change ($000)
+644,012 (15.1%)
New positions
23
Sold out positions
17
Turnover %
10.7%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
EWTX 133,381 53.0%
LLY 93,878 40.8%
MBX 54,065 77.2%
GPCR 48,903 153.3%
UPB 47,485 44.3%
BMY 41,804 NEW
PFE 41,157 NEW
SION 37,563 34.5%
ELV 34,740 NEW
HELP 31,415 NEW
Top Reduces (Value $000, Stocks/ETFs)
ELVN -40,355 -24.8%
SIBN -37,963 -100.0%
SCPH -34,358 -100.0%
ITGR -29,966 -100.0%
RNAM -26,719 -37.4%
AKRO -24,984 -100.0%
ALNY -22,689 -16.5%
MLYS -20,144 -36.2%
EXAS -18,695 -34.4%
SYK -18,557 -14.0%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 12,818 (0.3% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type