ORBIMED ADVISORS LLC

Q4 2025 13F-HR Detailed Holdings

Location
New York, NY
Holdings as of
12/31/2025
Date filed
2/17/2026
Form type
13F-HR
Num holdings
108
Total value ($000)
$4,899,392
Net value change ($000)
+644,012 (15.1%)
New positions
23
Sold out positions
17
Turnover %
10.7%
Sector allocation + QoQ delta (equities-only)

Holdings broken out by other managers reported in the original SEC filing. View aggregated holdings

You are on the SEC detailed breakdown page. Rows are shown as reported in the filing (including other manager, discretion, and voting authority fields), and are not merged like the standard holdings view. Switch to aggregated holdings.

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
EWTX 133,381 53.0%
LLY 93,878 40.8%
MBX 54,065 77.2%
GPCR 48,903 153.3%
UPB 47,485 44.3%
BMY 41,804 NEW
PFE 41,157 NEW
SION 37,563 34.5%
ELV 34,740 NEW
HELP 31,415 NEW
Top Reduces (Value $000, Stocks/ETFs)
ELVN -40,355 -24.8%
SIBN -37,963 -100.0%
SCPH -34,358 -100.0%
ITGR -29,966 -100.0%
RNAM -26,719 -37.4%
AKRO -24,984 -100.0%
ALNY -22,689 -16.5%
MLYS -20,144 -36.2%
EXAS -18,695 -34.4%
SYK -18,557 -14.0%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 12,818 (0.3% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type Discretion Other Manager Sole Shared None

Other Managers

Num Name File Number
1 ORBIMED CAPITAL LLC 028-10410