ORBIMED ADVISORS LLC

Q1 2026 13F-HR Holdings

Location
New York, NY
Holdings as of
3/31/2026
Date filed
5/15/2026
Form type
13F-HR
Num holdings
114
Total value ($000)
$5,045,364
Net value change ($000)
+145,972 (3.0%)
New positions
23
Sold out positions
21
Turnover %
25.8%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Prev filing: 2/17/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q4 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
ELVN 189,437 154.5%
AZN 132,177 NEW
MYGN 122,875 NEW
EWTX 103,741 26.9%
MRK 79,800 NEW
CRVS 49,653 90.0%
XENE 41,593 207.5%
GH 40,199 NEW
PRAX 27,725 99.5%
SNDX 22,479 NEW
Top Reduces (Value $000, Stocks/ETFs)
LLY -105,892 -32.7%
UPB -103,339 -66.9%
TERN -86,993 -100.0%
BSX -81,203 -35.2%
ALNY -75,467 -65.7%
APLS -61,038 -100.0%
EW -58,561 -37.3%
CI -56,422 -100.0%
RAPT -55,645 -100.0%
SYK -54,260 -47.5%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 459,937 (9.1% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type