Siren, L.L.C.

Q2 2025 13F-HR Detailed Holdings

Location
New York, NY
Holdings as of
6/30/2025
Date filed
8/13/2025
Form type
13F-HR
Num holdings
111
Total value ($000)
$1,932,436
Net value change ($000)
+159,656 (9.0%)
New positions
15
Sold out positions
21
Turnover %
10.0%
Sector allocation + QoQ delta (equities-only)

Holdings broken out by other managers reported in the original SEC filing. View aggregated holdings

Prev filing: 5/23/2025 Next filing: 11/13/2025 SEC filing
You are on the SEC detailed breakdown page. Rows are shown as reported in the filing (including other manager, discretion, and voting authority fields), and are not merged like the standard holdings view. Switch to aggregated holdings.

Snapshot: Change Analysis

Compared to Q1 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
KYMR 60,917 68.7%
SRRK 30,247 10.2%
MLTX 23,990 NEW
LXRX 18,872 105.2%
DYN 17,613 62.0%
AKRO 17,003 NEW
TSHA 16,389 181.0%
AVBP 15,239 NEW
RVMD 14,603 73.3%
TNGX 13,713 390.1%
Top Reduces (Value $000, Stocks/ETFs)
BPMC -64,273 -100.0%
NAMS -17,511 -44.7%
PRTA -15,884 -100.0%
SMMT -13,407 -100.0%
SLNO -12,814 -24.7%
ONC -12,275 -9.0%
VERA -12,124 -67.6%
APLS -11,758 -20.9%
CRNX -8,072 -14.3%
WAVE LIFE SCIENCES LTD -5,840 -19.6%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type Discretion Other Manager Sole Shared None

Other Managers

Num Name File Number
1 Invus Financial Advisors, LLC 028-19938
2 Invus Group, LLC 028-24462