RTW INVESTMENTS, LP

Q1 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
3/31/2025
Date filed
5/15/2025
Form type
13F-HR
Num holdings
68
Total value ($000)
$6,538,372
Net value change ($000)
-74,404 (-1.1%)
New positions
11
Sold out positions
15
Turnover %
8.3%
Sector allocation + QoQ delta (equities-only)
Prev filing: 2/14/2025 Next filing: 8/14/2025 SEC filing

Snapshot: Change Analysis

Compared to Q4 2024
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
AKRO 109,495 57.4%
ISRG 100,270 NEW
VRNA 96,302 113.9%
PTGX 64,347 30.3%
ZLAB 47,646 72.5%
PTCT 47,614 14.3%
MDGL 45,177 7.3%
GEHC 41,969 NEW
BBNX 40,390 NEW
GHRS 37,372 160.5%
Top Reduces (Value $000, Stocks/ETFs)
BRKR -145,443 -100.0%
DYN -105,268 -85.6%
RCKT -104,358 -46.9%
89bio, Inc. -44,174 -75.5%
NTRA -43,770 -10.7%
CRGX -42,692 -71.8%
ARVN -40,512 -63.4%
XNCR -29,651 -53.7%
SYRE -25,879 -30.7%
RDNT -22,954 -16.6%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type